Overview
Submission Instructions
Recent Publications
Frequently Asked Questions
Research Topics
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Genes & Diseases is a journal for molecular and translational medicine that focuses on investigations on the molecular bases and experimental therapeutics of human diseases. It publishes rigorously peer-reviewed original articles and authoritative reviews in basic and translational biomedical research, including molecular biology, molecular genetics, cell biology, cancer biology, immunity and infection, neuroscience, gene and cell-based therapies, and regenerative medicine.
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Subject
Genetics & Heredity
Impact Factor
9.4
Quartile
Q1
Open Access Type
Open
ISSN
2352-4820
eISSN
2352-3042
Invitation Only
No
Cost Range
Article Publishing Charge (APC): USD 3,000 (excluding taxes).
Submission Instructions
Genes & Diseases accepts the following article types. Click on an article type to view submission instructions.
Enabling And Emerging Technologies
Cover Letter
A one-page cover letter is required. Cover letter must include the corresponding author's full postal address, telephone number, and e-mail address, briefly explain the conceptual advance and broad significance of the findings, state that the work is not under consideration by any other primary scientific journals, and confirm that all authors have read and concurred with the manuscript.
Abstract
An abstract is required. Abstract must be unstructured and must not exceed 250 words. Abstract must be unstructured.
Manuscript
Manuscript must not exceed 6,000 words excluding abstract, references, figures, and tables. Manuscript must be structured as Abstract, Introduction, Material and Methods, Results, Discussion, Author contributions, Conflict of Interests, Funding, Acknowledgements, Appendix if applicable, and References. Manuscript must include at least five relevant keywords in alphabetical order and the sections Author contributions, Conflict of Interests, Funding, and Acknowledgements.
References
Manuscript may include a maximum of 80 references. References must be cited using consecutive superscript Arabic numerals in the order of appearance and listed in the same numerical order.
Figures & Tables
Manuscript may include a maximum of 8 tables and figures. Figures must be submitted as separate files and figure captions must be provided separately. Tables must be numbered consecutively in citation order and figures must be numbered according to their sequence in the text.
Clinical And Translational Investigation
Cover Letter
A one-page cover letter from the corresponding author is required. Cover letter must include the corresponding author's full postal address, telephone number, and e-mail address, a brief explanation of the conceptual advance and significance to a broad readership, a statement that the work is not under consideration by another primary scientific journal, and a statement that all authors have read and concurred with the manuscript content.
Abstract
An abstract is required. Abstract must be unstructured and must not exceed 250 words. Abstract must be unstructured.
Manuscript
Manuscript must not exceed 6,000 words excluding abstract, references, figures, and tables. Manuscript must be structured as Abstract, Introduction, Material and Methods, Results, Discussion, Author contributions, Conflict of Interests, Funding, Acknowledgements, Appendix if applicable, and References. At least five relevant keywords in alphabetical order must be provided below the abstract, and the manuscript must include Author contributions, Conflict of Interests, Funding, and Acknowledgements sections.
References
Manuscript may include a maximum of 80 references. References must be cited by consecutive superscript Arabic numerals in the order of appearance, and the reference list must be numbered in that same order.
Figures & Tables
Manuscript may include a maximum of 8 tables and figures. Figure captions must be supplied separately, each illustration must be submitted as a separate file, and source files are required whether or not figures are embedded in the text. Tables must be numbered consecutively with concise, self-explanatory headings, and all symbols and abbreviations used in figures must be explained.
Review Article
Cover Letter
A one-page cover letter is required. Cover letter must include the corresponding author's full postal address, telephone number, and e-mail address, a brief explanation of the conceptual advance and significance to a broad readership, a statement that the work is not under consideration by any other primary scientific journals, and a statement that all authors have read and concurred with the manuscript content.
Abstract
An abstract is required. Abstract must be unstructured and no more than 250 words. Abstract must be unstructured.
Manuscript
Manuscript should usually be less than 8,000 words excluding abstract, references, figures, and tables. Manuscript must be structured as Abstract, Introduction, main text subheadings, Conclusions, Author contributions, Conflict of Interests, Funding, Acknowledgements, Appendix if applicable, and References. At least five relevant keywords in alphabetical order must be provided below the abstract, and the manuscript must include Author contributions, Conflict of Interests, Funding, and Acknowledgements sections.
References
Manuscript should usually include fewer than 300 references. References must be cited by consecutive superscript Arabic numerals in the order of appearance and listed in the same numerical order.
Figures & Tables
Manuscript may include a maximum of 6 tables and figures. Captions for figures must be supplied separately and each illustration must be submitted as a separate file. Tables must be numbered consecutively with concise, self-explanatory headings, and figures must be numbered according to their sequence in the text with captions including a brief title and description.
Full Length Article
Cover Letter
A one-page cover letter from the corresponding author is required. Cover letter must include the corresponding author's full postal address, telephone number, and e-mail address, a brief explanation of the conceptual advance and significance to a broad readership, a statement that the work has not been under consideration by any other primary scientific journals, and a statement that all authors have read and concurred with the manuscript content.
Abstract
An abstract is required. Abstract must be unstructured and must not exceed 250 words. Abstract must be unstructured.
Manuscript
Manuscript must not exceed 6,000 words excluding abstract, references, figures, and tables. Text must be structured as Abstract, Introduction, Material and Methods, Results, Discussion, Author contributions, Conflict of Interests, Funding, Acknowledgements, Appendix if applicable, and References. At least five relevant keywords in alphabetical order must be provided below the abstract, and the manuscript must include Author contributions, Conflict of Interests, Funding, and Acknowledgements sections.
References
Manuscript may include a maximum of 80 references. References must be cited by consecutive superscript Arabic numerals in the order they appear in the text, and the reference list must be numbered in that same order.
Figures & Tables
Manuscript may include a maximum of 8 tables and figures. Each illustration must be submitted as a separate file and figure captions must be supplied separately. Tables must be numbered consecutively in citation order and illustrations must be numbered according to their sequence in the text.
Research Paper
Cover Letter
A one-page cover letter is required. Cover letter must include the corresponding author's full postal address, telephone number, and e-mail address, a brief explanation of the conceptual advance and significance to a broad readership, a statement that the work has not been under consideration by any other primary scientific journals, and a statement that all authors have read and concurred with the manuscript content.
Abstract
An abstract is required. Abstract must be less than 250 words. Abstract must be unstructured.
Manuscript
Article must include a title page, at least 5 relevant keywords in alphabetical order, main text, and where applicable acknowledgments, tables, figure captions, and figure files. A summary declaration of interest statement must be included in the title page file if double anonymized or in the manuscript file if single anonymized, author contribution descriptions must be provided, and at least 5 relevant keywords in alphabetical order must appear below the abstract.
References
References must use a numbered citation style with consecutive superscript Arabic numerals in order of appearance. Reference numerals must appear outside periods and commas and inside colons and semicolons, the reference list must be numbered in order of appearance, DOIs must be added when supplied, and all listed references must be cited in the text, tables, or figures and vice versa.
Figures & Tables
Each illustration must be submitted as a separate file and figure captions must be supplied separately. Tables must be numbered consecutively in citation order with concise, self-explanatory headings, and illustrations must be numbered according to their sequence in the text with all symbols and abbreviations explained.
Review Paper(Unsolicited)
Cover Letter
A one-page cover letter from the corresponding author is required. The cover letter must include the corresponding author's full postal address, telephone number, and e-mail address, a brief explanation of the conceptual advance and significance to a broad readership, a statement that the work is not under consideration by any other primary scientific journals, and a statement that all authors have read and concurred with the manuscript content.
Abstract
An abstract is required. Abstract must be less than 250 words. Abstract must be unstructured.
Manuscript
The article must include a title page, title, author names and affiliations, main text, and acknowledgments where applicable. At least five relevant keywords in alphabetical order must be provided below the abstract, and an authorship contribution description using the listed contribution categories must be included.
References
References must use a numbered citation style with consecutive superscript Arabic numerals. References must be numbered in the order of first appearance in the text, listed in the same order, include DOIs when supplied, and every listed reference must be cited in the text, tables, or figures and vice versa.
Figures & Tables
Figure captions must be supplied separately and each illustration must be submitted as a separate file, while all tables must be included in the article where applicable. Tables must be numbered consecutively with concise, self-explanatory headings, and figures must be numbered according to their sequence in the text with captions that include a brief title and explanation of symbols and abbreviations.
Rapid Communication
Cover Letter
A one-page cover letter is required. Cover letter must include the corresponding author's full postal address, telephone number, and e-mail address, briefly explain the conceptual advance and significance to a broad readership, and state that the work is not under consideration by any other primary scientific journals and that all authors have read and concurred with the manuscript.
Abstract
Abstract is not required.
Manuscript
Manuscript must not exceed 1,200 words excluding references, figures, and tables. Manuscript may optionally begin with the salutation 'To the Editor---'. At least 5 relevant keywords in alphabetical order must be provided below the abstract, and the article must include a title page.
References
Manuscript may include a maximum of 5 references. References must be cited using consecutive superscript Arabic numerals in the order of appearance, and the reference list must be numbered in that same order.
Figures & Tables
Manuscript may include a maximum of 1 table or figure. Figure captions must be supplied separately and each illustration must be submitted as a separate file.
Letters
Cover Letter
A one-page cover letter is required. Cover letter must include the corresponding author's full postal address, telephone number, and e-mail address, a brief explanation of the conceptual advance and broad significance of the findings, a statement that the work is not under consideration by any other primary scientific journals, and a statement that all authors have read and concurred with the manuscript content.
Abstract
An abstract is not required.
Manuscript
Manuscript must not exceed 1,200 words excluding references, figure, and table. Manuscript must begin with the salutation 'Dear Editor:'. At least 5 relevant keywords in alphabetical order must be included below the abstract or with the article.
References
Manuscript may include a maximum of 5 references. References must be cited by consecutive superscript Arabic numerals in the order of appearance and listed in the same numerical order.
Figures & Tables
Manuscript may include a maximum of 1 table or figure. Each illustration must be submitted as a separate file, figure captions must be supplied separately, and source files of figures and tables are required whether or not they are embedded in the text. Tables must be numbered consecutively and have a concise, self-explanatory heading, and figures must be numbered according to their sequence in the text with captions that include a brief title and description.
Correspondence
Cover Letter
A one-page cover letter from the corresponding author is required. Cover letter must include the corresponding author's full postal address, telephone number, and e-mail address, a brief explanation of the conceptual advance and significance to a broad readership, a statement that the work is not under consideration by any other primary scientific journals, and confirmation that all authors have read and concurred with the manuscript.
Abstract
Abstract is not required.
Manuscript
Manuscript must not exceed 1,000 words excluding references. At least 5 relevant keywords in alphabetical order must be provided.
References
Manuscript may include a maximum of 5 references. References must be cited by consecutive superscript Arabic numerals in the order they appear, and the reference list must be numbered in that same order.
Figures & Tables
Manuscript may include a maximum of 1 table or figure. Figure captions must be supplied separately and each illustration must be submitted as a separate file.
Recent Publications
Roles of DNA methyltransferases in hematopoiesis and hematologic malignancies
Xiaoyue Gao, Lixin Rui
10.1016/j.gendis.2026.102383
View Publication
ZNF334 suppresses colorectal cancer by inducing cell cycle arrest through UCHL1/ZYG11A-mediated perturbation of Cyclin B1–CDK1 complex
Ran Sun, Xiaoyu Liu, Lei Liu, Huan Rong, Yijia Gong, Xin Le, Weiyan Peng, Xi Peng, Zhaobo Cheng, Jun Tang, Qin Xiang, Yu Nie, Xiao Yang, Fang Zhang, Renyan Li, Yongzhong Wu, Yi Zhao, Fei Deng, Mingjun Zhang, Tingxiu Xiang
10.1016/j.gendis.2026.102381
View Publication
Glis1 regulates metabolic programming by promoting H3K18 lactylation to alleviate neuronal senescence following spinal cord injury
Dachuan Li, Xiao Lu, Zhaoyang Gong, Jianwei Wu, Yuxuan Zhang, Jiongdong Wu, Chenpei Xu, Xingyu Guo, Guangyu Xu, Haocheng Xu, Shuo Yang, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Shihao Lu, Junzhe Sheng, Xiaosheng Ma, Wei Zhu, Fei Zou, Chi Sun, Xiaochuan Gu, Yunzhi Guan
10.1016/j.gendis.2026.102382
View Publication
Advances in epigenetic factors in cancer cachexia associated-muscle atrophy
Li Li, Wazir Junaid, Fei Wang, Xiaolu Jin, Ranran Wang, Kai Lin, Zhiqiang Huang, Shiyu Song, Zhenghong Yu, Hongwei Wang
10.1016/j.gendis.2026.102380
View Publication
SLC25A26-mediated subcellular SAM redistribution alleviates cardiac hypertrophy by coordinating translation and bioenergetics
Ningning Guo, Jian Lv, Yu Fang, Qiuxiao Guo, Jiajie Li, Junmei Wang, Hongchao Zhan, Weihao Chen, Die Li, Yunong Deng, Xiao Ma, Qingqing Yan, Fuqing Jiang, Shuiyun Wang, Li Wang, Zhihua Wang
10.1016/j.gendis.2026.102379
View Publication
Frequently asked questions
How long does it take to publish?
20 days submission to first decision; 67 days submission to decision after review; 173 days submission to acceptance; 37 days from acceptance to first online publication.
Reformat to Genes & Diseases using Livewrite PremiumIs a cover letter required?
A one-page cover letter from the corresponding author is required. It must include the full postal address, telephone number, and e-mail address, explain the conceptual advance and significance of the findings, and state that the work is not under consideration elsewhere and that all authors have read and concurred with the manuscript.
Reformat to Genes & Diseases using Livewrite PremiumWhat are the publication costs?
Article Publishing Charge (APC): USD 3,000 (excluding taxes).
Reformat to Genes & Diseases using Livewrite PremiumResearch Topics
RNA modifications and cancer
Cancer-related molecular mechanisms research
Epigenetics and DNA Methylation
MicroRNA in disease regulation
Ferroptosis and cancer prognosis
Circular RNAs in diseases
Cancer, Hypoxia, and Metabolism
Cancer-related gene regulation
Ubiquitin and proteasome pathways
RNA Research and Splicing
Cancer Immunotherapy and Biomarkers
Autophagy in Disease and Therapy
Cancer Cells and Metastasis
Mitochondrial Function and Pathology
Cancer Genomics and Diagnostics
Cancer-related Molecular Pathways
CRISPR and Genetic Engineering
Immune cells in cancer
Liver Disease Diagnosis and Treatment
Extracellular vesicles in disease
Immune Cell Function and Interaction
Cancer, Lipids, and Metabolism
interferon and immune responses
RNA regulation and disease
Endoplasmic Reticulum Stress and Disease