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Clinical Therapeutics

Clinical Therapeutics is a peer-reviewed journal that publishes rapid reports on drugs, biologicals, diagnostics, pharmacoeconomics, health policy, treatment outcomes, and innovations in drug and biologics research and development. It covers work ranging from pivotal multicenter trials and pilot safety studies to pharmacokinetics, pharmacodynamics, bioavailability, biosimilarity, replication studies, negative trials, failed trials, comparative effectiveness, and pharmacoeconomics, along with commentaries and case reports. The journal uses blind peer review and emphasizes clinically relevant therapeutic research with implications for patient care, therapeutic development, or health policy.

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Subject Pharmacology & Pharmacy
Impact Factor 3.6
Quartile Q2
Open Access Type Hybrid
ISSN 0149-2918
eISSN 1879-114X
Invitation Only No
Cost Range USD 4250 APC excluding taxes for open access articles; no open access publication fee for subscription publication.

Submission Instructions

Clinical Therapeutics accepts the following article types. Click on an article type to view submission instructions.

Original Research

Cover Letter A cover letter is required for Express Track peer review requests and for FAERS-based adverse event studies to justify the study's novel contribution. Cover letter must include any Express Track peer review request and, for FAERS-based adverse event studies, the justification for the manuscript's novel contribution.
Abstract A structured abstract is required for Original Research manuscripts. Abstract must not exceed 400 words. Abstract must be structured.
Manuscript Main text must not exceed 6000 words. Manuscript must be structured as Introduction, Participants and Methods, Results, Discussion, and Conclusions. Manuscript must include 4 to 6 keywords, article highlights submitted as a separate editable file with 3 to 5 bullet points, and an AI declaration statement before the references if generative AI was used in manuscript preparation.
References References cited in the article must appear in the reference list, and references cited in the abstract must be given in full.
Figures & Tables Original Research manuscripts must include no more than 8 tables and figures. Tables must be submitted as editable text, while figures and other artwork must be supplied as separate files along with the manuscript. All tables and figures must be cited in the text, numbered in order of appearance, and include captions.
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Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 250 words.
Manuscript Manuscript must be divided into clearly defined sections using headings. Manuscript must include 1 to 7 keywords in English, article highlights of 3 to 5 bullet points submitted as a separate editable file, and a generative AI declaration section before the references if AI tools were used in manuscript preparation.
References References cited in the article must appear in the reference list and vice versa, references cited in the abstract must be given in full, and web references must include the full URL and date last accessed.
Figures & Tables Figures must be supplied as separate files, while tables must be submitted as editable text. Tables must be cited in the text, numbered consecutively, and include captions, and all artwork must be cited in the text, numbered by order of appearance, and include captions.
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Systematic Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required for Systematic Reviews. Abstract must not exceed 400 words. Abstract must be structured.
Manuscript Main text must not exceed 6000 words. Main text must be structured as Introduction, Methods, Results, Discussion, and Conclusions, and the title or subtitle must identify the article as a Systematic Review. Manuscript must include 4 to 6 keywords, article highlights, a summary with future directions, and an AI declaration section before the references if generative AI tools were used in manuscript preparation.
References References cited within the article must appear in the reference list, and references cited in the abstract must be given in full.
Figures & Tables Systematic Reviews must include no more than 6 tables and figures. Figures must be supplied as separate files, while the PRISMA-style flow diagram may be included as a figure or supplemental material. Tables must be submitted as editable text with captions and consecutive numbering, and all figures and tables must be cited in the text.
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Narrative Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required and must identify the article as a Narrative Review. Structured abstract must not exceed 400 words. Abstract must be structured.
Manuscript Main text must not exceed 6000 words. Main text must be structured as Introduction, Methods, Results (optional), Discussion, and Conclusions, with the Introduction describing the background, purpose, and perspective and the Methods describing the approach and literature search criteria, if any. Manuscript must include 4 to 6 keywords, article highlights, a references section, and an AI declaration statement before the references if generative AI was used in manuscript preparation.
References References requirements are not specified.
Figures & Tables Narrative Reviews must include no more than 6 tables and figures. Figures must be supplied as separate files and tables must be submitted as editable text. Each study discussed must report the study design, study population including age range and disease or severity, treatment dose and duration, and data and P values for valid comparisons.
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Brief Reports

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required for Brief Reports. Abstract must not exceed 250 words. Abstract must be structured.
Manuscript Main text must be 2000 to 3000 words. Manuscript must be structured as Introduction, Methods, Discussion, and Conclusions, and must also include Results and references. Manuscript must include 4 to 6 keywords, article highlights, and a generative AI declaration statement at the end of the manuscript before the references if AI tools were used in manuscript preparation.
References References must not exceed 30. Every reference cited in the text must appear in the reference list, and every reference in the reference list must be cited in the text.
Figures & Tables Brief Reports must include no more than 3 tables and figures. Figures must be uploaded as separate files, while tables must be submitted as editable text. All figures and tables must be cited in the text, numbered in order of appearance, and accompanied by captions.
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Pilot Studies

Cover Letter Cover Letter requirements are not specified.
Abstract Structured abstract is required. Abstract must not exceed 250 words. Abstract must be structured.
Manuscript Main text must be 2000 to 3000 words. Manuscript must be structured as Introduction, Methods, Discussion, and Conclusions, and must include Results and references. Manuscript must include 4 to 6 keywords, article highlights, and a generative AI declaration statement before the references if AI tools were used in manuscript preparation.
References Reference list must contain no more than 30 references.
Figures & Tables Manuscript must include no more than 3 tables and figures. Tables must be submitted as editable text and figures must be supplied as separate files along with the manuscript.
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Research Letters

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not be included.
Manuscript Main text must be 1000 to 2000 words. Manuscript must include a descriptive and succinct title, an Introduction specifying the rationale for the report beginning with a statement similar to "This communication provides...", a description of any new methods and results, and a Discussion/Conclusion section. Manuscript must include 4 to 6 keywords, selected references, and article highlights, and supplemental material is not permitted.
References Reference list must contain no more than 30 references.
Figures & Tables Manuscript must include no more than 2 tables and figures. Figures must be supplied as separate files and tables must be submitted as editable text.
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Case Reports

Cover Letter Cover letter is required and may include attached documentation of patient informed consent to publish. Cover letter must state whether the case was part of a larger study or meta-analysis and whether it was reported in aggregate elsewhere.
Abstract Abstract must not be included for Case Reports.
Manuscript Main text must be 1500 to 3500 words. Manuscript must be limited to retrospective analyses of one, two, or three clinical cases and include a descriptive, succinct title, an Introduction, and references. Manuscript must include 4 to 6 keywords and article highlights, and if generative AI was used in manuscript preparation an AI declaration must be added before the references.
References References must not exceed 15. References cited in the article must appear in the reference list and vice versa.
Figures & Tables Case Reports must include no more than 2 tables and figures. Figures must be uploaded as separate files, tables must be submitted as editable text, and supplemental material is not permitted. Tables and figures must be cited in the text, numbered in order of appearance, and provided with captions.
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Letters To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not be included.
Manuscript Main text must not exceed 1000 words. Manuscript must be unstructured.
References No more than 5 references may be included.
Figures & Tables No more than 1 table or figure may be included. Supplemental material is not permitted.
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Recent Publications

Efficacy and Safety Profile of a Triple Single-Pill Combination of Valsartan/Amlodipine/Chlorthalidone in Patients with Uncontrolled Hypertension

Hae-Young Lee, Soon-Yong Suh, Ho-Joong Youn, Woo-Baek Chung, Ki Hoon Han, Youngkeun Ahn, Dong-Hun Cha, Seong-Hwan Kim, Jong-Seon Park, Choong-Ki Kim, Jung-Sun Kim, Jin-ho Shin, Myeong-Ho Yoon, Jin-Bae Lee, Ji-Hyun Kim, Doo-Soo Jeon, Cheol-Woong Yu, Moo-Hyun Kim, Kyung-Hee Lim, Il-Suk Sohn, Jin-Ok Jeong, Chang-Gyu Park, You-Jung Choi, Chang-Hoon Lee, Junghwa Jeong, Seong-Bo Yoon, Sung-Uk Kwon, Sang-hyuk Yeo, Chong-Jin Kim

10.1016/j.clinthera.2026.05.010
View Publication

Novel Therapeutic Treatments in Perinatal Genetics Bridging Prenatal and Postnatal Care of Genetic Conditions

Melissa L. Russo, Rebecca Reimers, Asha N. Talati

10.1016/j.clinthera.2026.05.025
View Publication

Global Trends in Fixed-Dose Combination Drug Development: Regulatory Alignment and Structural Insights From FDA, EMA, and MFDS Approvals (2016–2024)

Myung-ah Chung, Eunjoo Pacifici

10.1016/j.clinthera.2026.04.006
View Publication

In Utero Gene Therapy for Sickle Cell Disease: Current Evidence, Ethical Considerations, and Future Directions—A Scoping Review

Efe Cudjoe, Margaret Thorsen, Nneka Molokwu, Melissa Russo

10.1016/j.clinthera.2026.04.026
View Publication

Clinical Characteristics and Outcomes of Immune Checkpoint Inhibitor Associated Renal Toxicities: A Retrospective Pan-Cancer Cohort Study

Charmi Trivedi, Julia Contini, MacKenzie Adams, Rebecca Z. Steuer, Sandeep Kumar Jain, Jacqueline J. Chu, Sapana R. Gupta, Curtis Petruzzelli, Kanika Malani, William Park, Maria Constantinou, Galina Lagos, May Min, Matthew J. Hadfield

10.1016/j.clinthera.2026.05.004
View Publication

Frequently asked questions

How long does it take to publish?

Express Track peer review is completed within 5-10 business days. A reject or revise decision is provided within 3 business days of receipt of reviewers' comments by the editorial office. Final decisions on revised Express Track manuscripts are made within 15 business days of receipt. Accepted Express Track manuscripts are published online within 20 days from acceptance, pending author approval of proof and payment of page charges. Proof corrections are due within 2 days.

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Is a cover letter required?

A cover letter is used for some submissions and requests. Topic update submissions should be identified in the cover letter. For FAERS adverse event studies, the cover letter should explain the novel contribution. Case reports should state whether the case was part of a larger study or meta-analysis and whether it was reported in aggregate elsewhere. Patient informed consent documentation for case reports can be attached to the cover letter. Express Track requests should be made in the cover letter.

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What are the publication costs?

Open access APC: USD 4250 excluding taxes for all articles. Subscription publication has no open access publication fee.

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Research Topics

Health Systems, Economic Evaluations, Quality of Life Diabetes Treatment and Management Pharmaceutical Economics and Policy Pharmaceutical studies and practices Diverse Scientific and Economic Studies Lipoproteins and Cardiovascular Health Medication Adherence and Compliance Pharmaceutical Practices and Patient Outcomes Blood Pressure and Hypertension Studies Diabetes, Cardiovascular Risks, and Lipoproteins Antibiotics Pharmacokinetics and Efficacy Diabetes Management and Research Lysosomal Storage Disorders Research Pharmacogenetics and Drug Metabolism Pharmacovigilance and Adverse Drug Reactions Asthma and respiratory diseases Human auditory perception and evaluation Inflammatory mediators and NSAID effects Rheumatoid Arthritis Research and Therapies Educational Robotics and Engineering Atrial Fibrillation Management and Outcomes Biosimilars and Bioanalytical Methods Pneumonia and Respiratory Infections Antiplatelet Therapy and Cardiovascular Diseases Heart Failure Treatment and Management

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