DM

Disease Models & Mechanisms

Disease Models & Mechanisms (DMM) is an open access journal that publishes rigorously peer-reviewed research in disease biology with significant translational impact at the interface of basic and clinical science. The journal is interdisciplinary in scope, covers a diverse range of diseases, and also publishes techniques and resources that advance the disease biology field.

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Subject Medicine, Research & Experimental, Pathology
Impact Factor 3.3
Quartile Q2
Open Access Type Open
ISSN 1754-8403
eISSN 1754-8411
Invitation Only No
Cost Range Article processing charge: $4,250 per article plus VAT if applicable; no charge for invited review-type articles or accepted Correspondence and Response articles; waivers and institutional Read & Publish agreements are available.

Submission Instructions

Disease Models & Mechanisms accepts the following article types. Click on an article type to view submission instructions.

Research Articles

Cover Letter Cover letter should clearly highlight the paper’s key findings and explain their significance and interest to the field.
Abstract Abstract is required. Abstract must not exceed 180 words. Abstract must be unstructured with no subheadings.
Manuscript Research Articles must contain no more than 8000 words including the main text and figure legends but excluding the title page, abstract, Materials and Methods section, and reference list. Manuscript should include an Introduction without subheadings, a Results section broken up by subheadings, and a Materials and Methods section divided into sections. Manuscript must include 3 to 6 keywords, a summary statement of up to 30 words, a dedicated AI-use declaration in Materials and Methods when applicable, and for new chemical compounds the chemical structure and method of synthesis.
References References must use the Harvard name-date citation style. References must be listed in a single reference list at the end of the article in alphabetical order by the first author’s surname and initials, with 'et al.' used after the 10th author when there are more than 10 authors.
Figures & Tables Research Articles must contain no more than eight display items including figures, tables, and boxes. For new submissions, a single PDF containing the text, figures with legends, and tables is recommended, while figures must not be embedded in the text and tables must be included in the manuscript file. Figures must be clearly numbered and accompanied by legends in the main text file, and bar graphs with error bars must show individual data points or use an acceptable alternative such as box-and-whisker plots or super plots.
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Systematic Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 180 words. Abstract must be unstructured and contain no subheadings.
Manuscript Systematic Reviews and Meta-Analyses must detail the search tools used, search terms and strategies, inclusion-exclusion criteria, sample size, analysis of publication quality, heterogeneity, and bias assessments. Manuscript must include a summary statement of up to 30 words and a dedicated Materials and Methods section declaring any AI tool use beyond simple language editing.
References References must use the Harvard name-date referencing system. References must be listed alphabetically by the first author's surname and initials, with 'et al.' used after the 10th author when there are more than 10 authors.
Figures & Tables For new submissions, authors are recommended to submit a single PDF containing the text, figures with legends, and tables, while figures must not be embedded in the text and tables must be included in the manuscript file. Figure legends must be included in the main text file, and tables must be editable rather than embedded as images.
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Meta-Analyses

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required and must not exceed 180 words. Abstract must not exceed 180 words. Abstract must be unstructured with no subheadings.
Manuscript Manuscript must detail the search tools used, search terms and strategies, inclusion-exclusion criteria, sample size, analysis of publication quality, heterogeneity, and bias assessments. Manuscript must include a summary statement of up to 30 words and a dedicated Materials and Methods section declaring any AI tool use beyond simple language editing.
References References must use the Harvard name-date citation style. References must be listed in alphabetical order by the first author's surname and initials, with 'et al.' used after the 10th author when there are more than 10 authors.
Figures & Tables Tables must be included in the manuscript file, while figures must not be embedded in the text and figure legends must be included in the main text file. Tables must be editable rather than embedded as images, and bar graphs with error bars must show individual data points or an acceptable alternative such as box-and-whisker plots or super plots when points are too numerous.
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Reviews

Cover Letter Cover letter should highlight the paper's key findings and explain their significance and interest to the field.
Abstract Reviews require a summary. The summary must be up to 250 words. The abstract or summary must be unstructured with no subheadings.
Manuscript Reviews may contain up to 5000 words of main text, depending on the topic and at the Editor's discretion. The manuscript must include a summary statement of up to 30 words, 3 to 6 keywords, a Data and resource availability section, and a dedicated AI declaration section in Materials and Methods when applicable.
References References must use the Harvard name-date referencing system. References must be listed in alphabetical order by the surname and initials of the first author, with 'et al.' used after the 10th author when there are more than 10 authors.
Figures & Tables Reviews may include three to five display items. For new submissions, authors are recommended to submit a single PDF containing the text, figures with legends, and tables, while figures must not be embedded in the text and tables must be included in the manuscript file. Figure legends must be included in the main text file rather than in the figure file.
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Resources & Methods

Cover Letter Cover letter should highlight the paper’s key findings and explain their significance and interest to the field.
Abstract Abstract is required. Abstract must not exceed 180 words. Abstract must be unstructured with no subheadings. Abstract must succinctly introduce the topic, place the study in the context of human disease, summarise the main findings, and clearly state the significance and translational implications in accessible language.
Manuscript Resources & Methods articles should contain a maximum of 8000 words, including the main text and figure legends but excluding the title page, abstract, Materials and Methods section, and reference list. Manuscript should include a Materials and Methods section with sufficient detail for replication and clear instructions on where the resource is deposited and how it can be obtained for research purposes. Manuscript must include 3 to 6 keywords, a summary statement of up to 30 words, a dedicated AI declaration in the Materials and Methods section if AI tools were used, and instructions on how any new tool, model, reagent, or resource can be accessed.
References References must use the Harvard name-date referencing system. References must be listed in a single alphabetical reference list at the end of the article, with 'et al.' used after the 10th author when a reference has more than 10 authors.
Figures & Tables Resources & Methods articles should contain no more than eight display items, including figures, tables and boxes. For new submissions, authors are recommended to submit a single PDF containing the text, figures with legends, and tables, while figure legends must be included in the main text file and tables must be included as part of the manuscript file. If new chemical compounds are described, the manuscript must include the chemical structure and method of synthesis.
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Correspondence

Cover Letter Authors must contact the Managing Editor with a brief description of the article before submitting Correspondence.
Abstract Abstract requirements are not specified.
Manuscript Correspondence must be a maximum of 1000 words.
References Correspondence must contain no more than ten references. References must use the Harvard name-date referencing system. References must be listed in alphabetical order by the first author's surname and initials, with 'et al.' used after the 10th author when a reference has more than 10 authors.
Figures & Tables Correspondence may include one figure or one table. For new submissions, authors are recommended to submit a single PDF containing the text, figures with legends, and tables, while figures must not be embedded in the text and tables must be included in the manuscript file. Figure legends must be included in the main text file rather than in the figure file, and tables must be editable and not embedded as images.
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Response

Cover Letter Cover letter should highlight the paper's key findings and explain their significance and interest to the field.
Abstract Abstract must be no more than 180 words. Abstract must be unstructured and contain no subheadings.
Manuscript Manuscript must be a maximum of 1000 words. Manuscript must include 3 to 6 keywords, a summary statement of up to 30 words, a Competing interests section, a Data and resource availability section, and a declaration of AI tool use in Materials and Methods when applicable.
References References must not exceed 10. References in the text must use the Harvard name-date style. References must be listed in alphabetical order by the first author's surname and initials, with 'et al.' used after the 10th author when there are more than 10 authors.
Figures & Tables A maximum of one figure or table may be included. Tables must be included in the manuscript file, while figures must not be embedded in the text and figure legends must be included in the main text file. Figures and tables must be clearly numbered and cited in the text in numerical order.
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Recent Publications

Placental defects revealed by modelling PWS in mice

Anna E. Webberley, Raquel Boque-Sastre, Lauren Bailey, Cerys Charles, Rachel A. Jones, Rosie Bunton-Stasyshyn, Michelle Stewart, Sara E. Wells, David S. Chatelet, Stephanie K. Robinson, Matthew J. Higgs, Rosalind M. John, Anthony R. Isles

10.1242/dmm.052833
View Publication

UBA1 knockdown dysregulates the levels of UBA1-sensitive proteins and impairs muscle function in Drosophila and mice

Michelle Curley, Flavia A. Graca, Anna Stephan, Wei Wang, Vishwajeeth R. Pagala, Yong-Dong Wang, Anthony A. High, Fabio Demontis

10.1242/dmm.052935
View Publication

Co-mutations of CTNNB1 and PTEN drive aggressive tumor progression in endometrial cancer

Shamsun Nahar, Eunhee M. Jeong, Keun Cheon Kim, Russell Broaddus, Jung-Yoon Yoo, Jae-Wook Jeong, Kyeong A. So, Tae Hoon Kim

10.1242/dmm.052788
View Publication

First person – Shamsun Nahar

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10.1242/dmm.053037
View Publication

A Drosophila tumor model identifies a conserved Upd–JAK/STAT–Akh signaling axis associated with metabolic changes in cancer cachexia

Kewei Yu, Gurpreet S. Moroak, Esther M. Verheyen

10.1242/dmm.052659
View Publication

Frequently asked questions

How long does it take to publish?

Research and Resources & Methods articles are posted as accepted author manuscripts upon acceptance before copyediting and layout and before publication in an online issue. Revised manuscripts not submitted within 3 months of the initial decision are treated as new submissions.

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Is a cover letter required?

Authors should clearly highlight the key findings of the paper and explain its significance and interest to the field in their cover letter. A covering letter is requested when submitting previous peer review reports from another journal.

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What are the publication costs?

APC is $4,250 per article plus VAT if applicable for accepted Research Articles and Resources & Methods articles. Invited review-type articles and accepted Correspondence and Response articles are free to publish. Full or partial waivers and institutional Read & Publish coverage are available for eligible corresponding authors.

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Research Topics

Muscle Physiology and Disorders Zebrafish Biomedical Research Applications Mitochondrial Function and Pathology Genetic Neurodegenerative Diseases Congenital heart defects research CRISPR and Genetic Engineering Epigenetics and DNA Methylation Genetics, Aging, and Longevity in Model Organisms Adipose Tissue and Metabolism Neurogenetic and Muscular Disorders Research RNA Research and Splicing Genetics and Neurodevelopmental Disorders Cancer Cells and Metastasis Pluripotent Stem Cells Research Cardiomyopathy and Myosin Studies Pancreatic function and diabetes RNA modifications and cancer Endoplasmic Reticulum Stress and Disease Cellular transport and secretion Amyotrophic Lateral Sclerosis Research Lysosomal Storage Disorders Research Cancer, Hypoxia, and Metabolism Neuroinflammation and Neurodegeneration Mechanisms Parkinson's Disease Mechanisms and Treatments Translation Studies and Practices

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