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Drug Metabolism And Disposition

Drug Metabolism and Disposition is a journal in pharmacology and toxicology that publishes significant and original experimental findings from in vitro and in vivo systems on the metabolism and disposition of endogenous and exogenous compounds, including pharmacologic agents and environmental chemicals. It is positioned as a resource for medicinal chemists and biochemists interested in drug metabolism, drug-metabolizing enzymes, and regulation of enzyme gene expression.

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Subject Pharmacology & Pharmacy
Impact Factor 4
Quartile Q1
Open Access Type Hybrid
ISSN 0090-9556
eISSN 1521-009X
Invitation Only No
Cost Range USD 3500 APC excl. taxes for open access; no open access publication fee for subscription articles. ASPET members receive a 25% APC discount.

Submission Instructions

Drug Metabolism And Disposition accepts the following article types. Click on an article type to view submission instructions.

Original Research Articles

Cover Letter A letter of submission is required. The cover letter must include author approval of the submission.
Abstract An abstract is required. Abstract must not exceed 250 words. Abstract must be unstructured and able to stand alone.
Manuscript Introduction must not exceed 750 words and Discussion must not exceed 1,500 words. Manuscript must include an Introduction with aims or hypotheses and relevant background, a Materials and Methods section, Results, and a concise Discussion, with an optional stand-alone conclusions section or conclusions presented within the Discussion or Results and Discussion. Manuscript must include 3 to 6 keywords, a significance statement of no more than 80 words immediately after the abstract, a separate glossary list of field-specific terms, a first-page footnote defining nonstandard abbreviations, an AI declaration section before the references if generative AI was used, and acknowledgements in a separate section directly before the reference list.
References References must use a numbered style with superscript Arabic numerals cited in order of appearance. Reference list entries must be numbered in order of appearance and journal names must be abbreviated according to LTWA.
Figures & Tables Figures must be uploaded as separate files, figure captions must be provided in a separate file, and tables must be submitted as editable text. Tables and figures must be cited and numbered consecutively in the text, tables must include captions, and data with fewer than four values must be presented in the text rather than as a separate table or figure.
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Minireviews

Cover Letter A letter of submission must be included.
Abstract An abstract is required. Abstract is limited to 250 words. Abstract must be a single paragraph. Abstract must indicate the scope of the minireview and summarize the major contents presented.
Manuscript The manuscript body should generally range from 4,000 to 6,000 words excluding the reference list. The body should preferably include Introduction, Brief historical perspective, Key recent advances, Current challenges and knowledge gaps, Perspective on future directions, and Conclusions sections. The manuscript must include 3 to 6 keywords and a separate significance statement, and any use of generative AI in manuscript preparation must be declared in a section placed before the references list.
References There is no limit to the number of references. References in the text must be cited with superscript Arabic numerals and listed in the reference list in the order of appearance.
Figures & Tables Figures must be supplied as separate files, figure captions must be provided in a separate file, and tables must be submitted as editable text. Tables must be numbered consecutively, cited in the text, and include captions, and all images must be cited in the text and numbered according to their sequence of appearance.
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Letters To The Editor

Cover Letter A letter of submission must be included. Null
Abstract Abstract is not required for Letters To The Editor. Null Null Null
Manuscript Null Null A declaration of generative AI use in manuscript preparation must appear in a new section before the references list when applicable.
References Null References must use numbered citations with superscript Arabic numerals in order of appearance. The reference list must be numbered in order of appearance in the text, and journal names must be abbreviated according to LTWA.
Figures & Tables Null Figures must be supplied as separate files, while tables must be submitted as editable text. Tables must include captions and be cited consecutively in the text.
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Perspectives

Cover Letter A letter of submission is required.
Abstract Abstract must not exceed 250 words. Abstract must be unstructured and able to stand alone.
Manuscript A significance statement of no more than 80 words must appear immediately after the abstract, keywords are optional, and any use of generative AI in manuscript preparation must be declared in a new section before the references list at first submission.
References References must be cited as superscript Arabic numerals in the order of appearance and listed in the reference list in that same numerical order, with journal names abbreviated according to LTWA.
Figures & Tables Figures must be uploaded as separate files with captions provided in a separate file, while tables must be submitted as editable text rather than images. Tables must be cited in the text, numbered consecutively, and include captions with notes placed below the table body.
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Commentary

Cover Letter A letter of submission is required. The submission letter must include approval of the article by all authors.
Abstract An abstract is required. Abstract must not exceed 250 words. Abstract must be unstructured and able to stand alone.
Manuscript A significance statement of 1–2 sentences and no more than 80 words must appear immediately after the abstract, and a declaration of generative AI use in manuscript preparation must appear in a new section before the references list when applicable.
References References must be cited with superscript Arabic numerals in order of appearance and listed in the reference list in that same numbered order.
Figures & Tables Figures must be supplied as separate files with captions provided in a separate file, while tables must be submitted as editable text. Tables must include captions and be cited and numbered consecutively in the text.
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Recent Publications

Human Cytochrome P450 27A1 - a variety of reactions, applications, and potentials for drug targeting

Michael J. Reddish, Johanna E. Papa, Amy Brown

10.1016/j.dmd.2026.100337
View Publication

Role of organic anion transporting polypeptides in pancreatic statin disposition and islet cell function in mice

Chen Bei Hu, Rennian Wang, Rommel G. Tirona, Ute I. Schwarz

10.1016/j.dmd.2026.100339
View Publication

The regulatory potential of cytochrome P450–Adrenodoxin interactions: insights toward understanding redox partner regulation in drug metabolizing enzymes

Janie E. McGlohon, D. Fernando Estrada

10.1016/j.dmd.2026.100338
View Publication

Construction of a Curated Human Pharmacokinetics Database for Molecular Fragment Analysis and Machine Learning Applications

Lianjin Cai, Mai McWilliams, Jingchen Zhai, Lei Xie, Junmei Wang

10.1016/j.dmd.2026.100341
View Publication

Reduction of Secondary 3-Keto Bile Acids by Aldo-Keto Reductase 1C1 and 1C4.

Keith D. Green, Graham K. Thomason, Lindsay C. Czuba

10.1016/j.dmd.2026.100340
View Publication

Frequently asked questions

How long does it take to publish?

Accepted articles are published online as pre-proof articles as soon as possible after acceptance. Proof corrections are requested within two days.

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Is a cover letter required?

A letter of submission is included in the submission checklist. Presubmission inquiries must include a cover letter with the manuscript type, abstract, significance statement, and full author information. Unsolicited minireviews are advised to include a presubmission inquiry with a cover letter.

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What are the publication costs?

Open access APC: USD 3500 excluding taxes for all articles. Subscription publication has no open access publication fee. ASPET members are eligible for a 25% APC discount.

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Research Topics

Pharmacogenetics and Drug Metabolism Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection Eicosanoids and Hypertension Pharmacology Metabolism and Genetic Disorders Diverse Scientific and Economic Studies Analytical Chemistry and Chromatography Inflammatory mediators and NSAID effects Human auditory perception and evaluation Educational Robotics and Engineering Computational Drug Discovery Methods HIV/AIDS drug development and treatment Chemical Reactions and Isotopes Diet and metabolism studies Hormonal Regulation and Hypertension Estrogen and related hormone effects Cancer therapeutics and mechanisms Amino Acid Enzymes and Metabolism Antibiotics Pharmacokinetics and Efficacy Cancer Treatment and Pharmacology Metabolomics and Mass Spectrometry Studies Liver Disease Diagnosis and Treatment Biochemical and Molecular Research Carcinogens and Genotoxicity Assessment

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