Overview Submission Instructions Recent Publications Frequently Asked Questions Research Topics

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Expert Opinion on Drug Metabolism & Toxicology

Expert Opinion on Drug Metabolism & Toxicology is a MEDLINE-indexed international subscription-based journal publishing rigorously peer-reviewed review articles and original papers on all aspects of ADME-Tox. The journal incorporates author expert opinion on the impact of topics on research and clinical practice and future developments, and it covers metabolic, pharmacokinetic and toxicological issues relating to specific drugs, drug-drug interactions, drug classes, enzymes involved in drug metabolism and excretion, study techniques, and novel technologies for obtaining ADME-Tox data.

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Subject Pharmacology & Pharmacy, Toxicology

Impact Factor 3.4

Quartile Q2

Open Access Type Hybrid

ISSN 1742-5255

eISSN 1744-7607

Invitation Only No

Cost Range Institutional subscription: online only USD 7,896.00; print & online USD 11,543.00.

Submission Instructions

Expert Opinion on Drug Metabolism & Toxicology accepts the following article types. Click on an article type to view submission instructions.

Review Article

Cover Letter Cover Letter requirements are not specified.

Abstract A structured abstract is required. Abstract must not exceed 200 words. Abstract must be structured. Abstract must include the headings Introduction, Areas covered, and Expert Opinion/Commentary in that order.

Manuscript Manuscript should be divided using headings, sub-headings, and title paragraphs. Manuscript must include an Article Highlights section, 5–8 keywords, and a statement disclosing whether and how generative AI was used in the research and manuscript preparation process.

References References must follow the journal's NLM reference guide. References must be numbered consecutively in order of first mention and listed at the end in numerical order using square-bracketed citation numbers.

Figures & Tables A maximum of five figures and five tables is permitted. Tables must be supplied as editable files.

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Original Research

Cover Letter A covering letter is required for Original Research submissions. The covering letter must provide the corresponding author’s full contact details, state that the work is original and not previously published or simultaneously submitted elsewhere, confirm all authors have read and approved the manuscript and met ICMJE conditions, identify the body granting ethical approval, disclose declarable financial or other relationships and support, and mention any abstract, poster, or oral presentations.

Abstract A brief structured abstract is required on the second page. The abstract must not exceed 200 words. The abstract should be structured. The abstract should use the headings Background, Research design and methods, Results, and Conclusions.

Manuscript Original Research articles must include a title page and the sections Introduction, Patients and Methods, Results, Discussion, Conclusions, Acknowledgements, and Author Contributions. The manuscript must include an Article Highlights section, 4–6 keywords in alphabetical order, an acknowledgements section with declaration of interest and related contributions, an author contributions section, and a statement disclosing whether and how generative AI was used or stating that it was not used.

References References must follow the journal’s NLM reference guide. References must be numbered consecutively in order of first mention and cited in the text with bracketed numbers in square brackets, with the reference list presented at the end in numerical order.

Figures & Tables A maximum of five figures and five tables is permitted. Tables must be supplied as editable files.

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Systematic Reviews

Cover Letter Cover Letter requirements are not specified.

Abstract A structured abstract is required. Abstract must not exceed 200 words. Abstract must be structured using the headings Introduction, Methods, Results, and Conclusions. Abstract must include Introduction, Methods, Results, and Conclusions.

Manuscript The article body must include the sections Introduction, Methods, Results, and Discussion. Manuscript must include an Article Highlights section, 4 to 10 keywords in alphabetical order, funding information, potential conflicts of interest alongside an author contribution statement, registration details including registration numbers where applicable, important references marked with one or two asterisks and brief annotations, and a statement disclosing whether and how generative AI was used.

References Around 100 references are suggested for a full-length review. References must follow the journal's NLM reference guide. References must be numbered consecutively in order of first mention and listed at the end in numerical order, and important references must be marked with one or two asterisks and briefly annotated.

Figures & Tables Up to 5 figures and up to 5 tables are permitted. Permission documentation for previously published figures, including licenses or written approval, should be uploaded alongside the manuscript. Tables and or plots must be used to support the presentation of results.

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Meta-Analysis

Cover Letter Cover Letter requirements are not specified.

Abstract A structured abstract is required. Abstract must not exceed 200 words. Abstract must be structured with article-type-specific headings. Abstract must use the headings Introduction, Methods, Results, and Conclusions.

Manuscript Article body must include the sections Introduction, Methods, Results, and Discussion. Manuscript must include an Article Highlights section, 4 to 10 keywords in alphabetical order, funding information, registration details, a conflict of interest statement with an author contribution statement, important reference annotations, and a statement disclosing whether and how generative AI was used.

References Around 100 references are suggested for a full-length review. References must follow the journal's NLM reference guide. References must be numbered consecutively in order of first mention and listed in numerical order with bracketed square-number citations reused for repeated references.

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Drug Evaluation

Cover Letter Cover Letter requirements are not specified.

Abstract A structured abstract is required for Drug Evaluations. Abstract must not exceed 200 words. Abstract must be structured. Abstract must use the headings Introduction, Areas covered, and Expert Opinion.

Manuscript Manuscript must not exceed 3,000 words excluding tables, figures, and references. Manuscript must include sections on introduction, market overview, introduction to the compound, chemistry, pharmacodynamics, pharmacokinetics and metabolism, pharmacogenetics, clinical efficacy, safety/tolerability/toxicity and potential off-target effects, drug-drug interactions, dosing routes, regulatory affairs, conclusion, and Expert Opinion. Manuscript must include an Article Highlights section, 5–8 keywords in alphabetical order, a drug summary box, a table summarizing published pharmacokinetic parameters, a financial and competing interests disclosure, and a statement disclosing whether and how generative AI was used.

References References should not exceed 100. References must follow the journal's NLM reference guide. References must be numbered consecutively in order of first citation, presented in numerical order with square-bracketed numbers, and important references must be marked with one or two asterisks and brief annotations.

Figures & Tables A maximum of five figures and five tables is permitted. Tables must be supplied as editable files, and the manuscript must include a table summarizing published pharmacokinetic parameters such as AUC, Cmax, Cmin, Ctrough, Tmax, and oral clearance CL/F.

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Letter To The Editor

Cover Letter Cover Letter requirements are not specified.

Abstract Abstract requirements are not specified.

Manuscript Letter To The Editor submissions are limited to 1500 words. Manuscripts must include an Article Highlights section and a statement disclosing whether and how generative AI was used, or state that it was not used.

References Letter To The Editor submissions must contain no more than 15 references. References must follow the journal's NLM reference guide. References must be numbered consecutively in order of first citation, cited in square brackets, listed numerically, and must include the article under discussion.

Figures & Tables Letter To The Editor submissions must not contain figures or tables.

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Recent Publications

Gastrointestinal bleeding risk among antithrombotics users: a propensity score matched study of drug classes

Prajwal M. Pradhan, Erich Kummerfeld, Steven Johnson, Gyorgy Simon, Terrence Adam

10.1080/17425255.2026.2686707

View Publication

Evaluation of the pharmacokinetics of emerging therapeutics for high grade glioma

Antonio Ruggiero

10.1080/17425255.2026.2683584

View Publication

Complex in vitro model developers’ perspective on advanced hepatic in vitro culture methods for predictive drug safety

Maria Vittoria Colombo, Anna Borgström, Bruno Guy Henri Filippi

10.1080/17425255.2026.2683592

View Publication

Transplacental pharmacokinetics and developmental toxicity of chemotherapeutic agents: a comparative analysis of fetal and pediatric exposure profiles

Antonio Ruggiero

10.1080/17425255.2026.2683594

View Publication

Citalopram serum concentrations in men and women of pre- and post-menopausal age

Eline L. Bosch, Franciska de Beer, Danielle C. Cath, Shiral S. Gangadin, Daan J. Touw, Iris E.C. Sommer

10.1080/17425255.2026.2682178

View Publication

Frequently asked questions

How long does it take to publish?

Double blind peer review involves at least two independent referees. Accelerated Publication Plus offers a final decision in as little as 3 weeks from submission, with peer review in approximately 2 weeks, revised paper turnaround in 1 week, first proofs within 5 working days, and online publication usually 1-2 weeks after acceptance. Accelerated Publication offers a final decision in as little as 9 weeks from submission, with peer review in approximately 4 weeks, revised paper turnaround in 2 weeks, first proofs within 5 working days, and online publication usually 2-3 weeks after acceptance. Accepted Author Version is published online in 3 days once the copyright form has been received. Proof corrections should be returned within 48 hours.

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Is a cover letter required?

A covering letter is required. It must include corresponding author contact details, originality and exclusive submission statements, author approval confirmation, ethical approval information, and disclosure of financial or other declarable relationships. Manuscripts without a covering letter or a Disclosure Form are not considered complete submissions.

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What are the publication costs?

Institutional subscription: online only USD 7,896.00; print & online USD 11,543.00.

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Research Topics

Pharmacogenetics and Drug Metabolism Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies Computational Drug Discovery Methods Drug-Induced Hepatotoxicity and Protection HIV/AIDS drug development and treatment Antibiotics Pharmacokinetics and Efficacy Diabetes Treatment and Management Pharmaceutical studies and practices Eicosanoids and Hypertension Pharmacology Antiplatelet Therapy and Cardiovascular Diseases Chemotherapy-induced organ toxicity mitigation Metabolomics and Mass Spectrometry Studies Schizophrenia research and treatment Epilepsy research and treatment Biosimilars and Bioanalytical Methods Renal Transplantation Outcomes and Treatments Treatment of Major Depression Diverse Scientific and Economic Studies Human auditory perception and evaluation Pancreatic function and diabetes Animal testing and alternatives Educational Robotics and Engineering Neurotransmitter Receptor Influence on Behavior Carcinogens and Genotoxicity Assessment

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