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JAMA

JAMA is a general medical journal in the JAMA Network that publishes research, reviews, opinion pieces, clinical review and education content, and multimedia features.

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Subject Medicine, General & Internal
Impact Factor 55
Quartile Q1
Open Access Type Hybrid
ISSN 0098-7484
eISSN 1538-3598
Invitation Only No
Cost Range Without any author fees.

Submission Instructions

JAMA accepts the following article types. Click on an article type to view submission instructions.

Original Investigation

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.
Abstract A structured abstract is required. The abstract must be structured.
Manuscript Text must not exceed 3000 words, excluding the abstract, tables, figures, acknowledgments, references, and online-only material. The manuscript file must include a title page, abstract, text, references, and, as appropriate, figure legends and tables. The manuscript must include 3 Key Points and a Data Sharing Statement.
References References must follow AMA style. References must be numbered in the order of appearance, cited with superscript arabic numerals, not alphabetized, list up to 6 authors or editors, use the first 3 followed by "et al." if more than 6, abbreviate journal names according to PubMed, and include the issue number after the volume number for journal references.
Figures & Tables No more than 5 tables and/or figures are permitted. Figures must be submitted as separate files, while tables must be included at the end of the manuscript file and not uploaded as separate files. Each table and figure must be numbered, cited in the text, and limited to material needed to support the article, and primary outcome data must not be presented only in figures.
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Systematic Review (Without Meta-Analysis)

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.
Abstract A structured abstract is required. Abstract must be no more than 350 words. Abstract must be structured. Abstract must use the headings Importance, Objective, Evidence Review, Findings, and Conclusions and Relevance.
Manuscript Manuscript text must not exceed 3000 words, excluding the abstract, tables, figures, acknowledgments, references, and online-only material. Manuscript must include Abstract, Introduction, Methods, Results, Discussion, and Conclusions, and the subtitle should be "A Systematic Review." Key Points of 75 to 100 words are required and must use the headings Question, Findings, and Meaning.
References Manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, list up to 6 authors or editors, use the first 3 followed by "et al." if more than 6, abbreviate journal names according to PubMed, and include the issue number in journal references.
Figures & Tables No more than 5 tables and/or figures are permitted. Figures must be submitted as separate files rather than included in the manuscript text, while tables must be included at the end of the manuscript file and not uploaded as separate files. Include a table with ratings of study or evidence quality, construct tables summarizing search results, and treatment summary tables should include treatment name, strength of evidence, treatment effect preferably with 95% confidence intervals, adverse effects, and very brief comments if necessary.
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Narrative Review

Cover Letter A cover letter is required.
Abstract A 3-part structured abstract is required. Abstract must not exceed 300 words. Abstract must be structured in 3 parts. Abstract must use the headings Importance, Observations, and Conclusions and Relevance.
Manuscript Manuscript length is typically 2000 to 3500 words maximum. Manuscript should include Abstract, Introduction, Methods if included, Discussion/Observations, and Conclusions, with the subtitle "A Review."
References Manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript arabic numerals, not alphabetized, with up to 6 authors or editors listed and the first 3 followed by "et al." when there are more than 6.
Figures & Tables No more than 5 tables and/or figures are permitted. Figures must be submitted as separate files, and tables must be included at the end of the manuscript file rather than uploaded separately. For most Narrative Reviews, tables should summarize epidemiology, diagnostic tools, and available therapies, and a fourth table should compare the review findings with current clinical practice recommendations and/or diagnostic and therapeutic uncertainty and controversies.
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Clinical Trial

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.
Abstract A structured abstract is required. The abstract must be structured and end with trial registration information including the registry name, trial ID, and URL.
Manuscript The manuscript text must not exceed 3000 words, excluding the abstract, tables, figures, acknowledgments, references, and supplemental material. The manuscript must clearly state an objective or hypothesis, design and methods, essential features of interventions, primary and secondary outcome measures consistent with the trial protocol, main results, discussion of study limitations, and conclusions. The manuscript must include 3 Key Points, a Data Sharing Statement, a power or sample size calculation statement, and for randomized trials the subtitle phrase "A Randomized Clinical Trial" or for nonrandomized clinical trials "A Nonrandomized Clinical Trial."
References The manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, list up to 6 authors or editors, use the first 3 followed by "et al" if more than 6, abbreviate journal names according to PubMed, and include the issue number in journal citations.
Figures & Tables No more than 5 tables and/or figures are permitted. Figures must be submitted as separate files rather than embedded in the manuscript text, while tables must be included at the end of the manuscript file and not uploaded separately. Each table and figure must be numbered, given a descriptive title, and cited in the text, and figures with more than 4 panels must not be submitted unless justified.
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Meta-Analysis

Cover Letter A cover letter is required.
Abstract A structured abstract is required. Abstract must not exceed 350 words. Abstract must be structured. Abstract must use the headings Importance, Objective, Data Sources, Study Selection, Data Extraction and Synthesis, Main Outcomes and Measures, Results, and Conclusions and Relevance.
Manuscript Text must not exceed 3000 words, excluding the abstract, tables, figures, acknowledgments, references, and online-only material. The manuscript should systematically describe the search and selection process and specify the study or analysis type, population, intervention, exposure, and tests or outcomes for each included article or data source. Include 3 Key Points and a Data Sharing Statement, and use the subtitle phrase "A Meta-analysis."
References Include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, list up to 6 authors or editors, and use the first 3 followed by "et al." when there are more than 6.
Figures & Tables No more than 5 tables and/or figures are permitted. Figures must be submitted as separate files, while tables must be included at the end of the manuscript file and not uploaded separately. Each table and figure must be numbered, cited in the text, and given a descriptive title, and primary outcome data must not be presented only in figures.
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Caring For The Critically Ill Patient

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.
Abstract A structured abstract is required. The abstract must be structured.
Manuscript Text must not exceed 3000 words, excluding the abstract, tables, figures, acknowledgments, references, and online-only material. The manuscript must include a title page, abstract, text, references, and figure legends and tables as appropriate. The manuscript must include a list of 3 Key Points and a Data Sharing Statement.
References References must follow AMA style. References must be numbered in the order cited, identified in the text with superscript Arabic numerals, list up to 6 authors or editors, and use the first 3 followed by "et al." when there are more than 6.
Figures & Tables No more than 5 tables and/or figures are permitted. Figures must be submitted as separate files, and tables must be included at the end of the manuscript file rather than uploaded separately. Each table and figure must be numbered, given a descriptive title, and cited in the text.
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Brief Report

Cover Letter A cover letter is required.
Abstract A structured abstract is required. The abstract must be structured.
Manuscript Recommended length is 1200 words, excluding the abstract, tables, figures, acknowledgments, references, and online-only material. The manuscript must include a structured abstract. The manuscript must include a list of 3 Key Points and should disclose any use of artificial intelligence in the Acknowledgment section or Methods section.
References No more than 15 references are permitted. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, list up to 6 authors or editors before using the first 3 followed by "et al.," and use PubMed journal abbreviations.
Figures & Tables No more than 3 tables and/or figures are permitted. Tables must be included at the end of the manuscript file, while figures must be submitted as separate files rather than embedded in the manuscript text. Every table and figure must be numbered, cited in the text, and given a descriptive title.
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Research Letter

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.
Abstract An abstract must not be included.
Manuscript Text must not exceed 800 words. Research Letters should generally be divided into Introduction, Methods, Results, and Discussion sections. Key Points must not be included, and a Data Sharing Statement is required.
References No more than 10 references are permitted. References must follow AMA style. References must be numbered in the order of appearance, cited with superscript Arabic numerals, and list up to 6 authors or editors or the first 3 followed by "et al." if there are more than 6.
Figures & Tables No more than 2 small tables or figures are permitted. Figures must be submitted as separate files rather than embedded in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, given a descriptive title, and cited in the text.
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Clinical Challenge

Cover Letter Cover letter is required.
Abstract Abstract requirements are not specified.
Manuscript The case presentation must be 250 words and the discussion must be 500 to 600 words. Submission must include a short title without the diagnosis, 4 single-phrase plausible treatment options for “What Would You Do Next?” with 1 preferred response, a 250-word case presentation, and a 500- to 600-word discussion.
References No more than 10 references are permitted. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, with all authors listed up to 6 and the first 3 followed by “et al.” if there are more than 6.
Figures & Tables Include 1 to 2 small figures. Figures must be submitted as separate files rather than included in the manuscript text. Submit the original unlabeled high-quality image files, with any labeled version provided separately for reference.
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Diagnostic Test Interpretation

Cover Letter Cover letter is required.
Abstract Abstract requirements are not specified.
Manuscript Overall text must not exceed 850 words. Manuscript must include a Case Presentation section of 200 words, a multiple-choice question section with 4 plausible responses and a single correct or best answer, a Test Characteristics section of approximately 200 words, an Application of Test Result to This Patient section of 200 words, a What Are Alternative Diagnostic Testing Approaches section of 100 words if applicable, a Patient Outcome section of 100 words, and a Clinical Bottom Line section with 3 to 5 bullet points.
References No more than 10 references are permitted. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, with journal names abbreviated per PubMed, up to 6 authors or editors listed and the first 3 followed by "et al." if more than 6, and journal references including the issue number in parentheses after the volume number.
Figures & Tables Exactly 1 table must be included. Tables must be included at the end of the manuscript file and not uploaded as separate files or as images, while figures must be submitted as separate files and not included in the manuscript text. Clinical images are not allowed, and laboratory, pathologic, or radiographic test results are appropriate.
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Letter To The Editor

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.
Abstract Abstract requirements are not specified.
Manuscript Letters must not exceed 400 words of text. Include the full name, academic degrees, and a single institutional affiliation for each author and the email address for the corresponding author.
References No more than 5 references are permitted. References must follow AMA style. References must be numbered in order of appearance and cited with superscript arabic numerals, with all authors listed up to 6 and the first 3 followed by "et al." when there are more than 6.
Figures & Tables Figures must be submitted as separate files rather than included in the manuscript text, while tables must be included at the end of the manuscript file.
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Recent Publications

Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury—Reply

Christian Stoppe, Andrew G. Day, Alexis F. Turgeon

10.1001/jama.2026.16512
View Publication

Glomerular Filtration Rates and Risk of Adverse Health Outcomes

Duncan J. Campbell

10.1001/jama.2026.16486
View Publication

Etiologies: Seeking Causation in Medicine and Poetry

Rafael Campo

10.1001/jama.2026.14270
View Publication

What Is an Autopsy?

Kristin L. Walter

10.1001/jama.2026.19248
View Publication

Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury

Harri Hemilä, Elizabeth Chalker

10.1001/jama.2026.16509
View Publication

Frequently asked questions

How long does it take to publish?

Median time to first decision is 2 days without external peer review and 25 days with review. Median time from acceptance to online first publication for research manuscripts is 43 days. JAMA Express offers expedited peer review and online publication within 4 weeks of submission.

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Is a cover letter required?

A cover letter is required and must include complete contact information for the corresponding author and disclosure of whether the authors have published, posted, or submitted any related papers from the same study.

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What are the publication costs?

Subscription access is offered, and individual article access is available for $45.00.

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Research Topics

Healthcare Policy and Management History of Medical Practice Pharmaceutical industry and healthcare Primary Care and Health Outcomes Medicine and Dermatology Studies History Health Systems, Economic Evaluations, Quality of Life Human auditory perception and evaluation Medical Malpractice and Liability Issues Diversity and Career in Medicine Empathy and Medical Education Biomedical Ethics and Regulation Healthcare cost, quality, practices Medical History and Innovations Medical Case Reports and Studies Diverse Scientific and Economic Studies Child and Adolescent Health Health Sciences Research and Education Health and Medical Research Impacts Innovations in Medical Education Palliative Care and End-of-Life Issues Pathogenesis and Treatment of Hiccups Medical Research and Practices Cardiac, Anesthesia and Surgical Outcomes Public Health Policies and Education Ethics and Legal Issues in Pediatric Healthcare

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