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Mayo Clinic Proceedings

Mayo Clinic Proceedings is a peer-reviewed clinical journal in general and internal medicine sponsored by Mayo Clinic that welcomes submissions from authors worldwide. Continuously published since 1926, it publishes clinically focused articles supporting the professional and educational needs of physicians and includes highly cited and Nobel-prize-winning research.

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Subject Medicine, General & Internal
Impact Factor 6.7
Quartile Q1
Open Access Type Hybrid
ISSN 0025-6196
eISSN 1942-5546
Invitation Only No
Cost Range Any figures submitted in color will appear in color at no additional charge to the author.

Submission Instructions

Mayo Clinic Proceedings accepts the following article types. Click on an article type to view submission instructions.

Original Articles

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required for Original Articles. Abstract must not exceed 250 words. Abstract must be structured for Original Articles. Abstract must use the headings Objective, Patients and Methods, Results, and Conclusion, and include the clinical trials registration number at the end if applicable.
Manuscript Manuscript must be arranged as title page, abstract, alphabetical list of abbreviations, text with appropriate headings and conclusion, acknowledgments, references, legends, tables, and illustrations, and the Patients and Methods section must provide the complete dates of the study. Manuscript must include key words in the submission metadata and, if AI or AI-assisted technologies were used in writing, a section titled 'Declaration of AI and AI-assisted technologies in the writing process' at the end of the core manuscript before the references.
References References must be cited consecutively in the text using superscript numerals, and the reference list must include all authors’ names and initials up to 6 authors or list 3 followed by 'et al' if more than 6 authors.
Figures & Tables Figures must not be embedded in the manuscript document and must be uploaded as separate files, while figure legends must be included in the manuscript document. Tables and figures must be numbered consecutively in order of citation, each table must appear on a separate page with a title, and graphical abstracts for Original Articles must be submitted as a separate file.
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Review Articles

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required. Abstract must not exceed 250 words. Systematic reviews must use a structured abstract with the standard MCP headings, whereas non-systematic review articles must use a nonstructured abstract. Systematic reviews must follow the standard MCP abstract headings.
Manuscript The abstract and manuscript text must describe the methods used to focus the literature search, including the search terms, date limitations, and how studies were selected for inclusion. Review articles must include 3-5 article highlights and any AI-assisted writing use must be disclosed in a section titled 'Declaration of AI and AI-assisted technologies in the writing process' placed before the references.
References References must be cited consecutively using superscript numerals, and the reference list must include all authors up to 6 or list the first 3 followed by 'et al' when there are more than 6 authors.
Figures & Tables Figures must be uploaded as separate files and not embedded in the manuscript document. Tables and figures must be numbered consecutively in the order cited in the text, each table must have a title, and each figure must have a legend provided in the manuscript document.
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Concise Reviews For Clinicians

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required. Abstract must not exceed 250 words.
Manuscript Manuscript must be arranged in the order of title page, abstract, list of abbreviations, text with appropriate headings and conclusion, acknowledgments, references, legends, tables, and illustrations. Manuscript must disclose any use of generative AI in a section titled 'Declaration of AI and AI-assisted technologies in the writing process' before the references, and a separate document must include 3 learning objectives and 5 CME-type questions with explanations and supporting references.
References References must be cited consecutively in the text using superscript numerals, list all authors when there are 6 or fewer or the first 3 followed by 'et al' when there are more than 6, and include title, source, year, volume, issue, page range, and DOI if available.
Figures & Tables Figures must be uploaded as separate files rather than embedded in the manuscript document. Tables and figures must be numbered consecutively in order of citation, each table must appear on a separate page with a title, and each figure must have a legend included in the manuscript document.
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My Treatment Approach

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 250 words.
Manuscript Manuscript must be arranged in the following order: title page, abstract, alphabetical list of abbreviations used at least 3 times in the body of the manuscript and their expansions, text with appropriate headings and conclusion, acknowledgments, references, legends, tables, and illustrations. If generative AI or AI-assisted technologies are used in writing, a declaration section must be included at the end of the core manuscript before the references list.
References References must be cited consecutively in the text using superscript numerals, and the reference list must include all authors' names and initials or list the first 3 followed by et al if there are more than 6 authors.
Figures & Tables Figures must be uploaded as separate files and not embedded in the manuscript document. Tables must be numbered consecutively with Arabic numerals and each table must have a title, and figures must be cited and numbered in order with a legend provided in the manuscript document.
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Consensus Recommendations

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 250 words.
Manuscript Manuscript must be arranged in the order of title page, abstract, list of abbreviations, text with appropriate headings and conclusion, acknowledgments, references, legends, tables, and illustrations. If generative AI or AI-assisted technologies are used in the writing process, the manuscript must include a section titled 'Declaration of AI and AI-assisted technologies in the writing process' before the references list.
References References must be cited consecutively with superscript numerals and listed with all authors if 6 or fewer or the first 3 followed by 'et al' if more than 6.
Figures & Tables Figures must be uploaded as separate files and not embedded in the manuscript document. Tables must be numbered consecutively and submitted on separate pages with titles, and each figure must have a legend included in the manuscript document.
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Clinical Practice Guidelines

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 250 words.
Manuscript Manuscript must be arranged in the following order: title page, abstract, alphabetical list of abbreviations used at least 3 times and their expansions, text with appropriate headings and conclusion, acknowledgments, references, legends, tables, and illustrations. If generative AI or AI-assisted technologies are used in the writing process, a declaration section with that title must be placed at the end of the core manuscript before the references list.
References References must be cited consecutively in the text using superscript numerals and listed with all authors if 6 or fewer or the first 3 authors followed by et al if more than 6, including title, source, year, volume, issue, expanded page ranges, and DOI if available.
Figures & Tables Figures must be uploaded as separate files rather than embedded in the manuscript document. Tables must be numbered consecutively in order of citation with each table on a separate page and a title, and figures must be cited and numbered consecutively with a legend provided in the manuscript document.
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Case Reports

Cover Letter Cover Letter requirements are not specified.
Abstract An unstructured abstract is required. Abstract must not exceed 250 words. Abstract must be unstructured.
Manuscript Manuscript should be approximately 800 to 1800 words. Manuscript text must include appropriate headings and a conclusion. The manuscript must include key words in the submission metadata and a declaration of AI and AI-assisted technologies in the writing process at the end of the core manuscript file before the references if such tools were used.
References References must be cited consecutively in the text using superscript numerals and listed with all authors if six or fewer or the first three followed by et al if more than six.
Figures & Tables Case Reports should generally include no more than 2 tables and no more than 2 figures. Figures must be uploaded as separate files rather than embedded in the manuscript document. Tables must be numbered consecutively and each have a title, and each figure must be cited in the text and accompanied by a legend in the manuscript document.
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Recent Publications

Symptomatic Mediastinal Parathyroid Adenoma

Julio C. Vasquez, Roshan Patel, Artur Narkiewicz-Jodko

10.1016/j.mayocp.2026.02.008
View Publication

Association of GLP-1 Receptor Agonist Use With Chronic Kidney Disease Risk in Type 2 Diabetes

Fu-Shun Yen, Chih-Cheng Hsu, Yao-Min Hung, Jing-Yang Huang, Chii-Min Hwu, James Cheng-Chung Wei

10.1016/j.mayocp.2026.01.035
View Publication

Proceedings From the Minnesota Learning Health Systems Symposium: The Role of Academic Partnership and (De)Implementation Science

Christopher R. Carpenter, Young J. Juhn, Victor M. Montori, Timothy J. Beebe, Genevieve B. Melton, Nancy C. Hawley, Matthew J. Spiten, Jenny A. Weis, James R. Cerhan, Brandon H. Hidaka, Dan P. Kelleher, Brian A. Lynch, Shauna M. Overgaard, Thanai Pongdee, Pravesh Sharma, Erik K. St Louis, Chung Wi, Hanyin Wang, Vesna D. Garovic, Hilal Maradit-Kremers

10.1016/j.mayocp.2026.01.028
View Publication

Comment on “Nonsurgical Integrative Treatments for Symptomatic Degenerative Lumbar Spondylolisthesis”

Bhumesh Tyagi, Leelabati Toppo, Aishwarya Biradar

10.1016/j.mayocp.2026.02.011
View Publication

In Reply: Comment on “Nonsurgical Integrative Treatments for Degenerative Symptomatic Lumbar Spondylolisthesis”

Wenchun Qu, Dan Yan, Brent A. Bauer, Zhen Wang, Jaehong Kim, Kiok Kim

10.1016/j.mayocp.2026.02.012
View Publication

Frequently asked questions

How long does it take to publish?

Median 14 days from submission to first decision.

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Is a cover letter required?

A cover letter is required for Rapid Review Pathway submissions and should identify the original journal, state that the manuscript was revised according to reviewers' comments and journal style, and request rapid review. Preprint submissions must acknowledge the preprint server deposit in the cover letter, including the deposition date and any associated URLs or DOIs. The Compass submissions should include a cover letter stating which Section Editor was consulted and that the manuscript is submitted for consideration in The Compass section.

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What are the publication costs?

Open access APC is USD 4640 excluding taxes for all articles. Subscription publication has no open access publication fee.

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Research Topics

Human auditory perception and evaluation Diverse Scientific and Economic Studies Legal Cases and Commentary Legal case studies and regulations Japanese History and Culture Medical History and Innovations History of Medical Practice Cardiac Imaging and Diagnostics Cardiac, Anesthesia and Surgical Outcomes Cardiac Valve Diseases and Treatments Venous Thromboembolism Diagnosis and Management Cardiovascular Function and Risk Factors Infective Endocarditis Diagnosis and Management Cardiac Arrhythmias and Treatments Health Systems, Economic Evaluations, Quality of Life Educational Robotics and Engineering Acute Myocardial Infarction Research Gastrointestinal disorders and treatments Esophageal and GI Pathology Atrial Fibrillation Management and Outcomes Gallbladder and Bile Duct Disorders Liver Disease Diagnosis and Treatment Streptococcal Infections and Treatments Innovations in Medical Education Medical Case Reports and Studies

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