Overview
Submission Instructions
Recent Publications
Frequently Asked Questions
Research Topics
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Mayo Clinic Proceedings is a peer-reviewed clinical journal in general and internal medicine sponsored by Mayo Clinic that welcomes submissions from authors worldwide. Continuously published since 1926, it publishes clinically focused articles supporting the professional and educational needs of physicians and includes highly cited and Nobel-prize-winning research.
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Subject
Medicine, General & Internal
Impact Factor
6.7
Quartile
Q1
Open Access Type
Hybrid
ISSN
0025-6196
eISSN
1942-5546
Invitation Only
No
Cost Range
Any figures submitted in color will appear in color at no additional charge to the author.
Submission Instructions
Mayo Clinic Proceedings accepts the following article types. Click on an article type to view submission instructions.
Original Articles
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract is required for Original Articles. Abstract must not exceed 250 words. Abstract must be structured for Original Articles. Abstract must use the headings Objective, Patients and Methods, Results, and Conclusion, and include the clinical trials registration number at the end if applicable.
Manuscript
Manuscript must be arranged as title page, abstract, alphabetical list of abbreviations, text with appropriate headings and conclusion, acknowledgments, references, legends, tables, and illustrations, and the Patients and Methods section must provide the complete dates of the study. Manuscript must include key words in the submission metadata and, if AI or AI-assisted technologies were used in writing, a section titled 'Declaration of AI and AI-assisted technologies in the writing process' at the end of the core manuscript before the references.
References
References must be cited consecutively in the text using superscript numerals, and the reference list must include all authors’ names and initials up to 6 authors or list 3 followed by 'et al' if more than 6 authors.
Figures & Tables
Figures must not be embedded in the manuscript document and must be uploaded as separate files, while figure legends must be included in the manuscript document. Tables and figures must be numbered consecutively in order of citation, each table must appear on a separate page with a title, and graphical abstracts for Original Articles must be submitted as a separate file.
Review Articles
Cover Letter
Cover Letter requirements are not specified.
Abstract
An abstract is required. Abstract must not exceed 250 words. Systematic reviews must use a structured abstract with the standard MCP headings, whereas non-systematic review articles must use a nonstructured abstract. Systematic reviews must follow the standard MCP abstract headings.
Manuscript
The abstract and manuscript text must describe the methods used to focus the literature search, including the search terms, date limitations, and how studies were selected for inclusion. Review articles must include 3-5 article highlights and any AI-assisted writing use must be disclosed in a section titled 'Declaration of AI and AI-assisted technologies in the writing process' placed before the references.
References
References must be cited consecutively using superscript numerals, and the reference list must include all authors up to 6 or list the first 3 followed by 'et al' when there are more than 6 authors.
Figures & Tables
Figures must be uploaded as separate files and not embedded in the manuscript document. Tables and figures must be numbered consecutively in the order cited in the text, each table must have a title, and each figure must have a legend provided in the manuscript document.
Concise Reviews For Clinicians
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract is required. Abstract must not exceed 250 words.
Manuscript
Manuscript must be arranged in the order of title page, abstract, list of abbreviations, text with appropriate headings and conclusion, acknowledgments, references, legends, tables, and illustrations. Manuscript must disclose any use of generative AI in a section titled 'Declaration of AI and AI-assisted technologies in the writing process' before the references, and a separate document must include 3 learning objectives and 5 CME-type questions with explanations and supporting references.
References
References must be cited consecutively in the text using superscript numerals, list all authors when there are 6 or fewer or the first 3 followed by 'et al' when there are more than 6, and include title, source, year, volume, issue, page range, and DOI if available.
Figures & Tables
Figures must be uploaded as separate files rather than embedded in the manuscript document. Tables and figures must be numbered consecutively in order of citation, each table must appear on a separate page with a title, and each figure must have a legend included in the manuscript document.
My Treatment Approach
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must not exceed 250 words.
Manuscript
Manuscript must be arranged in the following order: title page, abstract, alphabetical list of abbreviations used at least 3 times in the body of the manuscript and their expansions, text with appropriate headings and conclusion, acknowledgments, references, legends, tables, and illustrations. If generative AI or AI-assisted technologies are used in writing, a declaration section must be included at the end of the core manuscript before the references list.
References
References must be cited consecutively in the text using superscript numerals, and the reference list must include all authors' names and initials or list the first 3 followed by et al if there are more than 6 authors.
Figures & Tables
Figures must be uploaded as separate files and not embedded in the manuscript document. Tables must be numbered consecutively with Arabic numerals and each table must have a title, and figures must be cited and numbered in order with a legend provided in the manuscript document.
Consensus Recommendations
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must not exceed 250 words.
Manuscript
Manuscript must be arranged in the order of title page, abstract, list of abbreviations, text with appropriate headings and conclusion, acknowledgments, references, legends, tables, and illustrations. If generative AI or AI-assisted technologies are used in the writing process, the manuscript must include a section titled 'Declaration of AI and AI-assisted technologies in the writing process' before the references list.
References
References must be cited consecutively with superscript numerals and listed with all authors if 6 or fewer or the first 3 followed by 'et al' if more than 6.
Figures & Tables
Figures must be uploaded as separate files and not embedded in the manuscript document. Tables must be numbered consecutively and submitted on separate pages with titles, and each figure must have a legend included in the manuscript document.
Clinical Practice Guidelines
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must not exceed 250 words.
Manuscript
Manuscript must be arranged in the following order: title page, abstract, alphabetical list of abbreviations used at least 3 times and their expansions, text with appropriate headings and conclusion, acknowledgments, references, legends, tables, and illustrations. If generative AI or AI-assisted technologies are used in the writing process, a declaration section with that title must be placed at the end of the core manuscript before the references list.
References
References must be cited consecutively in the text using superscript numerals and listed with all authors if 6 or fewer or the first 3 authors followed by et al if more than 6, including title, source, year, volume, issue, expanded page ranges, and DOI if available.
Figures & Tables
Figures must be uploaded as separate files rather than embedded in the manuscript document. Tables must be numbered consecutively in order of citation with each table on a separate page and a title, and figures must be cited and numbered consecutively with a legend provided in the manuscript document.
Case Reports
Cover Letter
Cover Letter requirements are not specified.
Abstract
An unstructured abstract is required. Abstract must not exceed 250 words. Abstract must be unstructured.
Manuscript
Manuscript should be approximately 800 to 1800 words. Manuscript text must include appropriate headings and a conclusion. The manuscript must include key words in the submission metadata and a declaration of AI and AI-assisted technologies in the writing process at the end of the core manuscript file before the references if such tools were used.
References
References must be cited consecutively in the text using superscript numerals and listed with all authors if six or fewer or the first three followed by et al if more than six.
Figures & Tables
Case Reports should generally include no more than 2 tables and no more than 2 figures. Figures must be uploaded as separate files rather than embedded in the manuscript document. Tables must be numbered consecutively and each have a title, and each figure must be cited in the text and accompanied by a legend in the manuscript document.
Recent Publications
The Optimal Timing for Patients With Acute Myocardial Infarction to Safely Undergo Elective Non-Cardiac Surgery: A Retrospective Cohort Study
Chien-Chang Liao, Chuen-Chau Chang, Chun-Chieh Yeh, Ta-Liang Chen, Li-Chin Sung
10.1016/j.mayocp.2026.08.007
View Publication
Suzetrigine for Refractory Pain in Guillain-Barré Syndrome
David O. Sohutskay, Carmen R. Holmes, Eelco F.M. Wijdicks
10.1016/j.mayocp.2026.08.006
View Publication
52-Year-Old Woman With Dyspnea on Exertion
Cyrus M. Nouraee, Mia Poleksic, Kyle W. Klarich
10.1016/j.mayocp.2025.12.017
View Publication
22-Year-Old Woman With Dystonic Movements
Grace Ibitamuno, Joshua I. Daum, John G. Park
10.1016/j.mayocp.2025.08.027
View Publication
Cytokeratin-Expressing Plasma Cell Myeloma
Jennifer L. Herrick
10.1016/j.mayocp.2026.06.026
View Publication
Frequently asked questions
How long does it take to publish?
Median 14 days from submission to first decision.
Reformat to Mayo Clinic Proceedings using Livewrite PremiumIs a cover letter required?
A cover letter is required for Rapid Review Pathway submissions and should identify the original journal, state that the manuscript was revised according to reviewers' comments and journal style, and request rapid review. Preprint submissions must acknowledge the preprint server deposit in the cover letter, including the deposition date and any associated URLs or DOIs. The Compass submissions should include a cover letter stating which Section Editor was consulted and that the manuscript is submitted for consideration in The Compass section.
Reformat to Mayo Clinic Proceedings using Livewrite PremiumWhat are the publication costs?
Open access APC is USD 4640 excluding taxes for all articles. Subscription publication has no open access publication fee.
Reformat to Mayo Clinic Proceedings using Livewrite PremiumResearch Topics
Human auditory perception and evaluation
Diverse Scientific and Economic Studies
Legal Cases and Commentary
Legal case studies and regulations
Japanese History and Culture
Medical History and Innovations
History of Medical Practice
Cardiac Imaging and Diagnostics
Cardiac, Anesthesia and Surgical Outcomes
Cardiac Valve Diseases and Treatments
Venous Thromboembolism Diagnosis and Management
Cardiovascular Function and Risk Factors
Infective Endocarditis Diagnosis and Management
Cardiac Arrhythmias and Treatments
Health Systems, Economic Evaluations, Quality of Life
Educational Robotics and Engineering
Acute Myocardial Infarction Research
Gastrointestinal disorders and treatments
Esophageal and GI Pathology
Atrial Fibrillation Management and Outcomes
Gallbladder and Bile Duct Disorders
Liver Disease Diagnosis and Treatment
Streptococcal Infections and Treatments
Innovations in Medical Education
Medical Case Reports and Studies