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The Journal of Experimental Medicine

The Journal of Experimental Medicine is a Rockefeller University Press journal publishing experimental medicine research. The journal website features original research articles, brief definitive reports, reviews and opinions, current issues, archives, collections, and manuscript submission resources.

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Subject Immunology, Medicine, Research & Experimental
Impact Factor 10.6
Quartile Q1
Open Access Type Hybrid
ISSN 0022-1007
eISSN 1540-9538
Invitation Only No
Cost Range Flat-fee page charge; discounts or waivers available on request.

Submission Instructions

The Journal of Experimental Medicine accepts the following article types. Click on an article type to view submission instructions.

Articles

Cover Letter A cover letter should be included with the submission. Cover letter should describe the conceptual advance of the work, related or competing papers in press or under consideration elsewhere, conflicts of interest, whether the submission responds to a presubmission inquiry, and whether original data are archived and accessible for editorial review.
Abstract An abstract is required for submission. Abstract must not exceed 160 words. Abstract should be unstructured.
Manuscript Articles should be no more than 40,000 characters excluding spaces, figure legends, methods, references, and tables. Manuscript should include a Results section divided into subheadings and a comprehensive Materials and methods section, with supplemental Materials and methods not permitted. Manuscript should include a short running title, a title under 100 characters including spaces, an approximately 40-word summary statement for the online table of contents, a short summary paragraph of all supplemental material at the end of Materials and methods, and an alphabetical list of nonstandard abbreviations used in the paper.
References References for Articles are unlimited. In-text citations should use Harvard style. References should be formatted according to the reference guidelines and listed alphabetically by the first author's last name.
Figures & Tables Articles may include up to 10 figures and/or tables. Tables should be submitted as individual Word or Excel files and may not be submitted as images. Each figure or table must have a number and title or legend, figures must be cited in numerical order in the text, and scale bar measurements and symbol definitions must be included in figure legends where applicable.
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Review

Cover Letter A cover letter should be provided with the submission. Cover letter should describe the conceptual advance of the work, related or competing papers in press or under consideration elsewhere, conflicts of interest, whether the submission responds to a presubmission inquiry, and whether original data are archived and accessible for review.
Abstract An abstract is required. Abstract must not exceed 160 words. Abstract should be unstructured.
Manuscript Review articles are usually 6,000–7,000 words in length. A summary statement of approximately 40 words for the online table of contents is required, and supplemental text is not permitted other than figure and video legends.
References References for Reviews are unlimited. In-text citations should use Harvard style. References should be listed alphabetically by the first author's last name.
Figures & Tables Reviews must include three to four figures and/or tables. Tables should be submitted as individual Word or Excel files. Each table must include a table number and title.
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Brief Definitive Reports

Cover Letter A cover letter should be provided. Cover letter should describe the conceptual advance of the work, related or competing papers in press or under consideration elsewhere, conflicts of interest, whether the submission responds to a presubmission inquiry, and whether original data are archived and accessible for review.
Abstract An abstract is required. Abstract must not exceed 160 words. Abstract should be unstructured.
Manuscript Manuscript must be no more than 20,000 characters excluding spaces, figure legends, methods, references, and tables. Results and Discussion sections should be combined. A summary statement of approximately 40 words for the online table of contents and alerts and a short summary paragraph of all supplemental material at the end of the Materials and methods section are required.
References References are unlimited. In-text citations should use Harvard style. References should be listed alphabetically by the first author's last name.
Figures & Tables The article may include up to five figures and/or tables and up to three supplemental figures. Tables should be submitted as individual Word or Excel files. Each table must include a table number and title.
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Recent Publications

Turning cold tumors hot: Strategies to enhance antitumor immunity

Viktor German Steffensen, Mojca Bratina, Christina Tsiavou, Kjeld Schmiegelow, Daniela De Zio

10.1084/jem.20260378
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Launching an independent research laboratory and scientific career: Tools for a rapidly changing landscape

Simon F. Roy, Amy C. Fan, Kelsey B. Bennion, Mehdi Chaib, Hokyung K. Chung, Katey S.S. Enfield, Yael Gruper, Shelley M. Herbrich, Dongya Jia, Murad R. Mamedov, Annapaola Mariniello, Raphaël Mattiuz, Ray Pillai, Marie R. Siwicki, Alvaro Teijeira, Kate M. Warde, Chien-Huan Weng, Sean A. Yamada-Hunter, Jaroslav Zak, Zeda Zhang, Nir Hacohen

10.1084/jem.20261370
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The selected few: Mechanisms of HIV-1 reservoir persistence

Yanis Merad, Xu G. Yu, Mathias Lichterfeld

10.1084/jem.20252319
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Biallelic loss-of-function PTPN6 variants lead to inflammatory lung disease and hemolytic anemia

S. Farshid Moussavi-Harami, Matt S. Zinter, Marialetizia Motta, Luca Pannone, Paolo Calligari, Luca Mignini, Anne Slavotinek, Pierre-Marie Martin, Henry Sanchez, Lauren Sanchez, Iman Ragab, Clare L. Abram, Martin Broly, Yasmina Abi Ayad, Amina Serradj, Guilaine Boursier, Aida M. Bertoli-Avella, Mukunth Sadagopan, Nima Parvaneh, Sahar Sedighzadeh, Ebrahim Mirzaei, Mohammad Shahrooei, Amy P. Hsu, Steven M. Holland, Gianfranco Bocchinfuso, Lorenzo Stella, Simone Martinelli, Bruno Reversade, Marco Tartaglia, Clifford A. Lowell, Mark R. Looney, Alice Y. Chan

10.1084/jem.20252379
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Natural microbiota–based mouse models: A platform to fast-track translation of fundamental discoveries into the clinic

Mario Gößwein, Isabel Ulmert, Stephan P. Rosshart, Jonathan M. Coquet

10.1084/jem.20261517
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Frequently asked questions

How long does it take to publish?

Rapid decisions are made after weekly editor discussions of externally reviewed papers.

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Is a cover letter required?

Authors should provide a cover letter describing the conceptual advance, related or competing papers, conflicts of interest, and whether the submission follows a presubmission inquiry. The letter may include a requested editor, suitable reviewers, up to three reviewer exclusions, data archiving information, and prior reviewer comments from another journal.

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What are the publication costs?

Research Topics

T-cell and B-cell Immunology Immune Cell Function and Interaction Immunotherapy and Immune Responses Monoclonal and Polyclonal Antibodies Research Immune Response and Inflammation Glycosylation and Glycoproteins Research Cell Adhesion Molecules Research Immunodeficiency and Autoimmune Disorders Virus-based gene therapy research CAR-T cell therapy research Toxin Mechanisms and Immunotoxins Diabetes and associated disorders Viral gastroenteritis research and epidemiology Erythrocyte Function and Pathophysiology Animal Virus Infections Studies Streptococcal Infections and Treatments interferon and immune responses Complement system in diseases HIV Research and Treatment Cytokine Signaling Pathways and Interactions Cytomegalovirus and herpesvirus research Blood groups and transfusion Influenza Virus Research Studies RNA Interference and Gene Delivery NF-κB Signaling Pathways

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