LC

Liver Cancer

Liver Cancer publishes clinical and translational research on the causes, mechanisms, prevention, surveillance, diagnosis, and treatment of liver malignancy in humans and experimental models, including molecular targeted therapy, in the form of original and review articles.

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Subject Gastroenterology & Hepatology, Oncology
Impact Factor 9.1
Quartile Q1
Open Access Type Hybrid
ISSN 2235-1795
eISSN 1664-5553
Invitation Only No
Cost Range Article Processing Charges (APCs) apply for Gold Open Access and Open Access options in hybrid journals; waivers and discounts are available for authors without means.

Submission Instructions

Liver Cancer accepts the following article types. Click on an article type to view submission instructions.

Research Article

Cover Letter A cover letter is required. Cover letter must describe the knowledge gap addressed, discuss the research significance and implications, explain fit with the journal scope, emphasize the manuscript’s unique contribution, and name any special issue or collection invitation if applicable.
Abstract A short abstract is required. Abstract must be structured. Abstract must use the headings Introduction, Methods, Results, and Conclusion and must not include bibliographic references or references to figures or tables.
Manuscript Research Articles are typically 5000 words in length. Manuscript must include the sections Introduction, Methods, Results, and Discussion. Manuscript must include 3–5 keywords, a statements section after the main text and before the references, a Data Availability Statement, an Ethics Statement, and a clear declaration of any generative AI use in the Methods or Acknowledgements section.
References Citations must be numbered sequentially in square brackets, the reference list must contain only cited works in order of citation, and each reference may list up to 6 authors before using et al.
Figures & Tables Research Articles typically include 4 to 8 tables and figures. Figures and tables must be uploaded as separate files rather than embedded only in the manuscript. Figure legends must be placed at the end of the article after the references, and tables must be editable rather than submitted as images.
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Review Article

Cover Letter Cover letter is required. Cover letter must describe the knowledge gap addressed, discuss the manuscript's implications and significance, explain its fit with the journal's scope, and emphasize its unique and important contributions.
Abstract Abstract is required. Abstract must be structured. Abstract must use the headings Background, Summary, and Key Messages.
Manuscript Review Articles are typically 5000 words in length. Review Articles must include a critical discussion of the reported data and a clear conclusion with potential impacts on the standard of care. Manuscript must include 3–5 keywords and a statements section after the main text and before the references, and any use of generative AI must be declared in the Methods or Acknowledgements section.
References References must be cited sequentially in square brackets, listed numerically in order of citation, limited to six named authors before using "et al.", and include only works cited in the text.
Figures & Tables Review Articles typically include 4 to 8 tables and figures. Figures and tables must be uploaded as separate files, with figure legends included at the end of the manuscript text. Tables must be editable Word files rather than images.
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Systematic Review

Cover Letter Cover letter is required. Cover letter must describe the knowledge gap addressed, explain the implications and significance of the research, outline fit with the journal scope, emphasize the manuscript’s unique contribution, and name any special issue or invited collection if applicable.
Abstract A short abstract is required. Abstract must be structured. Abstract must use the subheadings Introduction, Methods, Results, and Conclusion.
Manuscript Manuscript must follow the Introduction, Methods, Results, Discussion format. Manuscript must include 3–5 keywords and a statements section after the main text and before the references, and any use of generative AI must be declared in the Methods or Acknowledgements.
References References must be cited sequentially in Arabic numerals within square brackets, listed only if cited in the text, ordered numerically by citation, and limited to six named authors before adding et al.
Figures & Tables Systematic Reviews typically include 4 to 8 tables and figures. Figures and tables must be uploaded as separate items in their original file format rather than embedded in the manuscript. Figure legends must appear at the end of the manuscript after the reference list and figures must be cited in text as “Figure” or in parentheses as “Fig.” followed by the number.
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Case Report

Cover Letter Cover Letter requirements are not specified.
Abstract A short abstract is required for Case Reports. The abstract must be structured. The abstract must use the headings Introduction, Case Presentation(s), and Conclusion.
Manuscript Case Reports are typically 2500 words in length. The manuscript must include Introduction, Case Report/Case Presentation, and Discussion sections, and it must include a substantive relevant literature review with an up-to-date review of previous relevant cases. The manuscript must include 3–5 keywords and statements after the main body and before the reference list, including Statement of Ethics, Conflict of Interest Statement, Funding Sources, Author Contributions, and Data Availability Statement, and any use of generative AI must be declared in the Methods or Acknowledgements section.
References References must be cited sequentially in the text using Arabic numerals in square brackets, listed numerically in order of citation, include only works cited in the text, and list up to 6 authors followed by "et al." if there are more than 6.
Figures & Tables Case Reports may include up to 3 tables and figures. Tables and figures must be submitted as separate files, and figure legends must be included at the end of the manuscript text after the reference list. Figure legends must use the format "Fig. 1. Legend text."
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Guidelines

Cover Letter A cover letter is required. Cover letter must describe the knowledge gap addressed, discuss the research implications and significance, outline fit with the journal scope, emphasize the manuscript's unique contribution, and identify any special issue or article collection invitation if applicable.
Abstract An abstract is required. Abstract must be unstructured.
Manuscript Guidelines are typically 5000 words in length. Guidelines should describe the clinical problem, explain how the statement was generated, include a review of the supporting evidence, and present the practice statement itself. Manuscript must include a statements section after the main text and before the references, and any use of generative AI must be declared in the Methods or Acknowledgements section.
References References must be cited sequentially in square brackets, listed numerically in order of citation, include only cited works, and list no more than 6 authors before adding "et al.".
Figures & Tables Guidelines may include up to 3 tables and figures. Figures and tables must be uploaded as separate files, with figure legends included at the end of the manuscript text.
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Letter

Cover Letter Cover letter is required. Cover letter must describe the knowledge gap addressed, discuss the significance and implications for the Editor, and explain how the manuscript fits the journal's scope and contributes uniquely to the field.
Abstract Abstract is not required.
Manuscript Letters are typically 1000 words in length. Letters should not include original data. Manuscript must include 3–5 keywords, a short title for use as the running head, a statements section before the references, and a declaration of any generative AI use in the Methods or Acknowledgements section as applicable.
References Citations must use sequential Arabic numerals in square brackets. References must include only cited works, be listed numerically in order of citation, and list no more than 6 authors before adding "et al.".
Figures & Tables Letters may include up to 3 tables and figures. Tables and figures must be uploaded as separate files, with figure legends placed at the end of the manuscript text and table headers included in the table files. Tables must be editable Word files rather than images.
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Registered Report-Stage 1

Cover Letter Cover letter is required. Cover letter must describe the knowledge gap addressed, discuss the research implications and significance, explain fit with the journal scope, and emphasize the manuscript's unique contribution.
Abstract Abstract must be unstructured.
Manuscript Manuscript must follow the structure of the article template provided on the Journal Guidelines page. Manuscript must include statements after the main body and before the references, including an Ethics Statement and a Data Availability Statement, and must declare any generative AI use in the Methods or Acknowledgements section.
References References must be cited sequentially in the text using Arabic numerals in square brackets and listed numerically in order of citation, with up to 6 authors named before adding "et al.".
Figures & Tables Figures and tables must be uploaded as separate files, with figure legends placed at the end of the manuscript text and table headers included in the table files. Tables must be editable Word files rather than images.
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Registered Report-Stage 2

Cover Letter Cover letter is required. Cover letter must describe the knowledge gap addressed, discuss the research significance and journal fit, and emphasize the manuscript’s unique contribution, with special issue details included if applicable.
Abstract Abstract must be unstructured.
Manuscript Manuscript must follow the structure of the journal’s article template and include an Ethics Statement and a Data Availability Statement. Manuscript must include statements after the main body and before the references, declare any generative AI use in the Methods or Acknowledgements, and provide 3 to 5 keywords on the title page.
References References must be cited sequentially in the text using Arabic numerals in square brackets, listed numerically in order of citation, include only cited works, and list up to 6 authors before adding et al.
Figures & Tables Figures and tables must be uploaded as separate files rather than embedded only in the manuscript text. Figure legends must be placed at the end of the article and each table must be editable in a separate MS Word file.
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Recent Publications

Real-World Evidence from a Nationwide Prospective Study of the Efficacy/Safety of Systemic Therapy for Unresectable Hepatocellular Carcinoma: First 1,000 Patients of the PRISM Study

Masafumi Ikeda, Shinji Itoh, Daisuke Onozuka, Sadahisa Ogasawara, Tomokazu Kawaoka, Takashi Niizeki, Taro Yamashita, Yasuhito Tanaka, Tomoharu Yamada, Kazushi Numata, Ryosuke Tateishi, Tatsuya Yamashita, Takuji Okusaka, Junji Furuse, Masatoshi Kudo

10.1159/000552686
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The China Paradox in LEAP-012 tiral

Masatoshi Kudo

10.1159/000552537
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Methodological Concerns in “Prognostic Usefulness of Clinical Complete Response after PD-1 Inhibitor-Based Combination Therapy for Unresectable Hepatocellular Carcinoma”

Shoujun Shen, Jiayan Chen, Bihua Yao

10.1159/000551852
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Real-World Efficacy and Safety of TACE Combined with Lenvatinib and PD-1 Inhibitor in Conversion Therapy for Unresectable Hepatocellular Carcinoma: A Multicenter Retrospective Study

Lin Ye, Guo-Xing Liu, Da-Long Yang, Fan-Jian Zeng, Jie Liu, Hong-Bing Yao, Jun-Liang Nong, Shao-Ping Liu, Ning Peng, Wen-Feng Li, Pei-Sheng Wu, Chuang Qin, Ze Su, Jun-Jie Ou, Xiao-Feng Dong, Yi-He Yan, Teng-Meng Zhong, Ming-Song Wu, Yao-Zhi Chen, Guo-Dong Wang, Mian-Jing Li, Xue-Yao Wang, Fu-Quan Yang, Shu-Chang Chen, Yong-Yu Yang, Kang Chen, Yong-Cheng Lai, Qing-Qing Pang, Xiu-Mei Liang, Xian-Shuang Mao, Yong-Rong Liang, Fu-Xin Li, Hao Shi, Ren-Jian Li, Bang-De Xiang, Liang Ma, Jian-Hong Zhong, Ya-Qun Yu

10.1159/000552409
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Addition of Intra-arterial Therapy to Immunotherapy Improves Outcomes in Unresectable Hepatocellular Carcinoma: Taiwan Multicenter Cohort Study

Teng-Yu Lee, Pei-Chang Lee, Ying-Chun Shen, Wei-Fan Hsu, Shiue-Wei Lai, Ching-Wei Chang, Yung-Yeh Su, Tung-Hung Su, Po-Ting Lin, Chia-Yen Dai, Ching-Sheng Hsu, San-Chi Chen, Kun-Ming Rau, I-Cheng Lee, Song-Ru Jhan, Tsung-Hao Liu, Hsueh-Chou Lai, Tsang-En Wang, Shi-Ming Lin, Po-Cheng Liang, Cheng-Hao Tseng, Pi-Yi Chang, Shu-Cheng Wu, Hung-Wei Wang, Shou-Wu Lee, Yi-Hsiang Huang

10.1159/000552375
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Frequently asked questions

How long does it take to publish?

Accepted papers are published online in the unedited original manuscript version within a few days of acceptance. Authors should respond to proof queries within 48 hours. Articles are published electronically ahead of print shortly after author approval to publish.

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Is a cover letter required?

A cover letter is required and should describe the gap in knowledge addressed by the manuscript, the implications and significance of the research, how the manuscript fits the journal scope, and the manuscript’s unique and important contributions. Submissions for a special issue or article collection should name the collection and identify who invited the submission where appropriate.

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What are the publication costs?

Article Processing Charges (APCs) apply for Gold Open Access and Open Access options in hybrid journals; waivers and discounts are available for authors without means.

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Research Topics

Hepatocellular Carcinoma Treatment and Prognosis Cholangiocarcinoma and Gallbladder Cancer Studies Liver Disease Diagnosis and Treatment Legal and Regulatory Analysis Linguistic, Cultural, and Literary Studies Military Technology and Strategies Cancer Immunotherapy and Biomarkers Cancer Mechanisms and Therapy Diverse Scientific and Economic Studies Hepatitis B Virus Studies Organ Transplantation Techniques and Outcomes Human auditory perception and evaluation Liver physiology and pathology Pancreatic and Hepatic Oncology Research Liver Disease and Transplantation Physics and Engineering Research Articles Hepatitis C virus research Cancer, Hypoxia, and Metabolism Colorectal Cancer Treatments and Studies Gallbladder and Bile Duct Disorders Cancer, Lipids, and Metabolism MRI in cancer diagnosis Renal cell carcinoma treatment Inflammatory Biomarkers in Disease Prognosis Radiomics and Machine Learning in Medical Imaging

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