MC

Molecular Cancer Research

Molecular Cancer Research publishes articles featuring novel, basic cancer research discoveries that prioritize broad molecular and cellular processes. Areas of emphasis include cell cycle and senescence; cell death and survival; chromatin, gene and RNA regulation; DNA damage and repair; genomics; oncogenes and tumor suppressors; and signal transduction.

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Subject Oncology
Impact Factor 4.7
Quartile Q1
Open Access Type Hybrid
ISSN 1541-7786
eISSN 1557-3125
Invitation Only No
Cost Range Manuscript submission fee: $35. Base publication fee: $1900 plus $250 per display item. Open access APC: $6000 for CC BY-NC-ND or $7000 for CC BY.

Submission Instructions

Molecular Cancer Research accepts the following article types. Click on an article type to view submission instructions.

Research Articles

Cover Letter A cover letter is required if AI was used to produce new text, images, or other material, or if submission restrictions or associated manuscripts must be described. The cover letter must describe any use of AI to produce new text, images, or other material, explain how any associated manuscript relates to the submission, and disclose any restrictions on availability of manuscript components.
Abstract Research Articles must include an abstract. The abstract must not exceed 250 words. The abstract structure is not specified beyond requiring inclusion of a statement of implication. The abstract must include a statement of implication.
Manuscript Research Articles must contain 5,000–6,000 words of text, excluding the cover page, abstract, methods section, tables, and references. The manuscript must include a declaration in the acknowledgments if generative AI or human-assisted editing services were used for manuscript preparation, and at least one named author must include the specified data responsibility statement on the title page.
References Research Articles must include 50 references.
Figures & Tables Research Articles may include up to 7 figures and/or tables. For initial submission, each figure must appear in sequential order and adjacent to its legend, ideally where it is first cited in the text.
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Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract Reviews must include an abstract. Abstract must be 250 words.
Manuscript Reviews must contain 6,000–7,000 words of text. Any use of generative artificial intelligence or human-assisted editing services for manuscript preparation must be declared in the acknowledgments section.
References Reviews must include 75 references.
Figures & Tables Reviews may include up to 7 figures and/or tables. For initial submission, each figure must appear in sequential order adjacent to its legend, ideally where it is first cited in the text.
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Rapid Impacts

Cover Letter Any use of AI to produce new text, images, or other material for the manuscript must be described in detail in the cover letter.
Abstract Abstract is required. Abstract must be 150 words. Abstract must include a statement of implication.
Manuscript Manuscript must contain 2,500 words of text, excluding the abstract, methods section, tables, references, and cover page. Manuscript must include a Visual Overview as a single 10 x 7.5 inch slide containing a clear and condensed diagrammatic summary of the major findings and biological implications, and any use of generative artificial intelligence or human-assisted editing services for manuscript preparation must be declared in the acknowledgments section.
References Manuscript must include 20 references.
Figures & Tables Manuscript may include up to 3 tables and/or figures. For initial submission, each figure must be presented in sequential order and adjacent to its legend, ideally where it is first called out in the text. Each figure or table is limited to a maximum of 4 panels.
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Minireviews

Cover Letter Any use of AI to produce new text, images, or other material for the manuscript must be described in detail in the cover letter.
Abstract An abstract is required for Minireviews. The abstract must be 250 words.
Manuscript The manuscript must contain 2,500–3,000 words of text, excluding the cover page, abstract, methods section, tables, and references. An acknowledgment section must declare any use of generative artificial intelligence or human-assisted editing services to assist with manuscript preparation.
References The manuscript must include 50 references.
Figures & Tables The manuscript may include up to 4 figures and/or tables. For initial submission, each figure must be presented in sequential order and adjacent to its legend, ideally where it is first called out in the text.
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Letters To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Text must contain 400 words. Title must be formatted as "Running title of the original article" — Letter.
References Letter must include 5 references. The first reference must cite the original article.
Figures & Tables Figures or tables may be included only if they show data that refute the conclusions of the original article. For initial submission, each figure must be presented in sequential order and adjacent to its legend, ideally where it is first called out in the text. Figures or tables showing unpublished data in support of the conclusions of the original article will not be considered.
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Recent Publications

Selected Articles from This Issue

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10.1158/1541-7786.mcr-24-6-hi
View Publication

Ceramide-induced endoplasmic reticulum stress reveals a targetable vulnerability in endocrine therapy-resistant breast cancer

Purab Pal, Shweta Chitkara, Godwin K. Sarpey, Aanshi Vashi, Vipin Rawat, Fatimah Alani, Huiping Zhao, Malik Ata, Jun Qu, Rachel Schiff, Debra Tonetti, Geoffrey L. Greene, Jonna Frasor, Gunes Ekin Atilla-Gokcumen, Jonathan L. Coloff

10.1158/1541-7786.mcr-25-0964
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Mapping the Subtype-Specific PARP1 ADP-ribosylated Proteome in Breast Cancer Cells

Sneh Koul, Minjung Kwon, Poulami Tapadar, Yangyang Dai, Weidan Song, Morgan Dasovich, Tulip Nandu, Dan Huang, Cristel V. Camacho, W. Lee Kraus

10.1158/1541-7786.mcr-25-1068
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Integrative Surface Antigen Profiling of KLK2 and STEAP1 in Advanced Prostate Cancer

Erolcan Sayar, Helen M. Richards, Roman Gulati, Radhika A. Patel, Brian Hanratty, Hyun Jung Lee, Ilsa Coleman, Pallabi Mustafi, Chien-Kuang Cornelia Ding, William S. Chen, David Quigley, Manu Setty, Joshua M. Lang, Lawrence D. True, Lori Kollath, Daniel W. Lin, Jun Luo, John K. Lee, Gavin Ha, Evan Y. Yu, Heather H. Cheng, Bruce Montgomery, Eva Corey, Colm Morrissey, Michael T. Schweizer, Peter S. Nelson, Ruben Raychaudhuri, Michael C. Haffner

10.1158/1541-7786.mcr-26-0052
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Variation at the R181 residue of p53 confers loss of p53 DNA binding cooperativity with the retention of mitochondrial-associated apoptosis

Renyta Moses, Alexandra Indeglia, Alison S. Levine, Ryan Hausler, Gregory Kelly, Sven A. Miller, Isabel Anez, Melissa Heller, Rosella Delgado, Caitlin Orr, Wendy Kohlmann, Anne Naumer, Jennie Vagher, Sophie R. Cahill, Luke D. Maese, John Karanicolas, Judy E. Garber, Maureen E. Murphy, Kara N. Maxwell

10.1158/1541-7786.mcr-26-0030
View Publication

Frequently asked questions

How long does it take to publish?

Decisions are typically returned within 35 days of submission. Accepted author manuscripts are usually posted OnlineFirst within 48 hours following formal acceptance.

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Is a cover letter required?

A cover letter is strongly encouraged for initial submission.

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What are the publication costs?

Manuscript submission fee: $35. Base publication fee: $1900 plus $250 per display item. Open access APC: $6000 for CC BY-NC-ND or $7000 for CC BY.

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Research Topics

Cancer-related Molecular Pathways Cancer, Hypoxia, and Metabolism Epigenetics and DNA Methylation RNA modifications and cancer Cancer Cells and Metastasis Ubiquitin and proteasome pathways DNA Repair Mechanisms Cancer Genomics and Diagnostics Hippo pathway signaling and YAP/TAZ PI3K/AKT/mTOR signaling in cancer Cancer Research and Treatments Cell Adhesion Molecules Research Prostate Cancer Treatment and Research Microtubule and mitosis dynamics Cancer-related molecular mechanisms research Cancer-related gene regulation Protein Degradation and Inhibitors RNA Research and Splicing Cancer, Lipids, and Metabolism MicroRNA in disease regulation PARP inhibition in cancer therapy Cell death mechanisms and regulation Melanoma and MAPK Pathways Wnt/β-catenin signaling in development and cancer Ferroptosis and cancer prognosis

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