JF

Journal for ImmunoTherapy of Cancer

The Journal for ImmunoTherapy of Cancer is an open access, peer-reviewed journal and the official journal of the Society for Immunotherapy of Cancer. It publishes research, literature reviews, position papers, practice guidelines, and case studies across tumor immunology and cancer immunotherapy, spanning basic science, translational, and clinical topics including tumor-host interactions, the tumor microenvironment, biomarkers, cellular and pharmaceutical therapies, vaccines, combination therapies, and immune-related toxicity.

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Subject Immunology, Oncology
Impact Factor 10.6
Quartile Q1
Open Access Type Open
eISSN 2051-1426
Invitation Only No
Cost Range Article Processing Charges apply; SITC members receive a 25% discount on APCs on papers where they serve as first, last, or corresponding author.

Submission Instructions

Journal for ImmunoTherapy of Cancer accepts the following article types. Click on an article type to view submission instructions.

Original Research

Cover Letter A personal cover letter is required as a separate attachment. The cover letter must explain the paper’s value to readers, its novel and original aspects, and how it advances the field.
Abstract A structured abstract is required. Abstract must be no more than 350 words. Abstract must be structured. Abstract headings must be Background, Methods, Results, and Conclusions.
Manuscript Manuscript length must be up to 5,000 words, excluding the title page, abstract, tables, acknowledgements, contributions, and references. Manuscript should include Methods, Results, and Discussion or Conclusion sections, with key messages placed after the abstract. Manuscript must include 3 to 10 keywords, a Declarations section, and a key messages section of 3 to 5 sentences using the headings 'What is already known on this topic', 'What this study adds', and 'How this study might affect research, practice or policy'.
References Reference list may contain up to 50 references. References must use Vancouver style. The reference list must be included as part of the main text document.
Figures & Tables A combined total of tables and figures must not exceed 7. Figures must be uploaded separately, while the reference list must remain in the main manuscript document.
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Reviews

Cover Letter A personal cover letter is required as a separate attachment. Cover letter must explain the paper's value to readers, its novel and original aspects, and how it advances the field.
Abstract An abstract is required. Abstract must be up to 350 words.
Manuscript Manuscript must be up to 5,000 words, excluding the title page, abstract, tables, acknowledgements, contributions, and references. Manuscript must include 3 to 10 keywords and a Declarations section.
References References may include up to 100 entries. References must use Vancouver style. The reference list must be included as part of the main text document.
Figures & Tables Manuscript may include up to 4 tables and figures.
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Case Reports

Cover Letter A personal cover letter is required as a separate attachment. Cover letter must explain why the paper is valuable to readers, describe the novel or mechanistic contribution and originality, and state how the work advances the field.
Abstract An abstract is required. Abstract must be 100–200 words. Abstract must be unstructured.
Manuscript Manuscript must be 500–1,500 words, excluding the title page, abstract, tables, acknowledgements, contributions, and references. Manuscript must include a one-sentence statement of clinical or biologic insight following the abstract. Manuscript must include 3 to 10 keywords and a Declarations section.
References Reference list may include up to 10 references. References must use Vancouver style. Reference list must be included as part of the main text document.
Figures & Tables Manuscript may include up to 2 tables and figures.
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Letters

Cover Letter A personal cover letter as a separate attachment is required. The cover letter must explain the paper's value to readers, its novel and original aspects, and how it advances the field.
Abstract Abstract must not be included.
Manuscript Manuscript must be up to 1,500 words, excluding the title page, abstract, tables, acknowledgements, contributions, and references. The manuscript must include 3 to 10 keywords, a Declarations section, and a statement of potential sources of conflict of interest.
References References are limited to up to 5. References must use Vancouver style. The reference list must be included as part of the main text document.
Figures & Tables Tables and figures must not be included.
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Guidelines

Cover Letter A personal cover letter is required as a separate attachment. The cover letter must explain the paper's value to readers, its novel and original aspects, and how it advances the field.
Abstract An abstract is required. Abstract must be no longer than 350 words.
Manuscript Manuscript must be up to 8,000 words, excluding the title page, abstract, tables, acknowledgements, contributions, and references. The manuscript must include a methods section and be divided into subsections with short, informative headings such as Questions to Explore, Literature Review and Analysis, and Consensus Recommendations. The manuscript must include 3 to 10 keywords and a Declarations section.
References Reference list may include up to 120 references. References must use Vancouver style. The reference list must be included as part of the main text document.
Figures & Tables The submission may include up to 4 tables and figures.
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Short Reports

Cover Letter A personal cover letter is required as a separate attachment. Cover letter must explain the paper's value to the journal readership, identify the novel and original aspects of the work, and describe how it contributes to advancement of the field.
Abstract An abstract is required. Abstract must be no longer than 350 words.
Manuscript Manuscript must be no longer than 2,500 words, excluding the title page, abstract, tables, acknowledgements, contributions, and references. Manuscript must include 3 to 10 keywords and a Declarations section.
References References are limited to 25. References must use Vancouver style. Reference list must be included as part of the main text document.
Figures & Tables A combined total of up to 4 tables and figures is allowed.
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Recent Publications

Novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneity

Julian Hübner, Marah Alsalkini, Rhonda McFleder, Fabio Toppeta, Julia Wagner, Renato Liguori, Björn Grams, Moritz Meyer-Hofmann, Leopold Diener, Camelia-Maria Monoranu, Carsten Hagemann, Fulvia Ferrazzi, Chi Wang Ip, Ralf-Ingo Ernestus, Hermann Einsele, Michael Hudecek, Mario Löhr, Thomas Nerreter, Vera Nickl

10.1136/jitc-2025-014693
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Spatially resolved single-cell landscape of tumor immunotypes reveals the central role of interferon signaling and plasmacytoid dendritic cells in triple-negative breast cancer

Yi Liu, Jodi M Carter, Yaohua Ma, Sachin K Deshmukh, George W Sledge, Justin M Balko, Jennifer M Kachergus, Ji Shi, Mark Gregory, Jingjing Gong, Heikki Joensuu, Edith A Perez, Daniel Stover, Lisa Carey, William M Sikov, Roberto Leon-Ferre, Keith L Knutson, Judy C Boughey, James N Ingle, Krishna R Kalari, Fergus J Couch, Yan W Asmann, Matthew P Goetz, E Aubrey Thompson, Saranya Chumsri

10.1136/jitc-2025-014020
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Chemotherapy induces an IL1β-dependent neutrophil recruitment and activation that promote chemoresistance in metastatic ovarian cancer

Taito Miyamoto, Yujie Ye, Marlaine M Soliman, Bryan S Manning, Brennah Murphy, Linna Zhu, Chunlei Shao, Gauri Mirji, Moeko Minakuchi, Kohei Hamada, Rin Mizuno, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Masaki Mandai, Ying Ye, Jayamanna Wickramasinghe, Yulia Nefedova, Rahul Shinde, Andrew Kossenkov, Nan Zhang

10.1136/jitc-2025-014253
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Systemic pre-conditioning favors effector over exhausted CD8 T-cell subsets following Sup2-IL33 armored CAR T-cell therapy

Shannon L Ferry, Leena Abdullah, Akshaya Balasubramanian, Elizabeth C Nowak, Allison Carl, Alexandrea Turnquist, Asmaa Mohamed, Edward Usherwood, Mark Sundrud, Yina Huang

10.1136/jitc-2025-013020
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IFN-γ PET imaging stratifies and predicts response to CD137 agonism in a syngeneic colorectal tumor model

Alexander John Deck, Allen-Dexter Saliganan, Savannah Lane, Hyejeong Jang, Kang Chen, Seongho Kim, Nerissa T. Viola

10.1136/jitc-2025-013930
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Frequently asked questions

How long does it take to publish?

Time to first decision without review is 8 days (median), time to first decision with review is 45 days (median), and time from acceptance to publication is 22 days (median).

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Is a cover letter required?

All submissions must include a personal cover letter as a separate attachment before the manuscript in the online submission system. The cover letter should explain the paper’s value to the readership, the novel and original aspects of the work, how it advances the field, and may identify preferred or non-preferred reviewers. A cover letter for case reports is requested to briefly explain the mechanistic and/or novel contribution to the field.

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What are the publication costs?

Article Processing Charges apply; SITC members receive a 25% discount on APCs on papers where they serve as first, last, or corresponding author.

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Research Topics

Cancer Immunotherapy and Biomarkers CAR-T cell therapy research Immunotherapy and Immune Responses Immune Cell Function and Interaction Immune cells in cancer Virus-based gene therapy research Monoclonal and Polyclonal Antibodies Research T-cell and B-cell Immunology Lung Cancer Treatments and Mutations Cancer Genomics and Diagnostics Cancer Research and Treatments Pancreatic and Hepatic Oncology Research Colorectal Cancer Treatments and Studies Ferroptosis and cancer prognosis Lung Cancer Research Studies Cancer Cells and Metastasis Bladder and Urothelial Cancer Treatments vaccines and immunoinformatics approaches Phagocytosis and Immune Regulation Melanoma and MAPK Pathways Renal cell carcinoma treatment Lymphoma Diagnosis and Treatment Cancer, Stress, Anesthesia, and Immune Response Peptidase Inhibition and Analysis Viral Infectious Diseases and Gene Expression in Insects

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