Overview Submission Instructions Recent Publications Frequently Asked Questions Research Topics

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Nature Cancer

Nature Cancer is a cancer research journal publishing Articles, Review Articles, Perspectives, News & Views, Research Briefings, News Features, Editorials and other content across cancer biology, clinical oncology, immunotherapy, diagnostics and related fields.

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Subject Oncology

Impact Factor 28.5

Quartile Q1

Open Access Type Hybrid

eISSN 2662-1347

Invitation Only No

Cost Range Some non-primary article types are not eligible for Open Access and can only be published using the subscription-based publishing route.

Submission Instructions

Nature Cancer accepts the following article types. Click on an article type to view submission instructions.

Article

Cover Letter A cover letter is required. Cover letter must explain the importance of the work, why it is appropriate for the diverse readership of Nature Cancer, and whether there have been prior discussions with a Nature Cancer editor about the work.

Abstract An abstract is required. Abstract must be up to 150 words. Abstract must be unstructured and unreferenced.

Manuscript Main text must be up to 4,000 words excluding the abstract, Methods, references and figure legends. Article must be divided into an unheaded Introduction, Results, Discussion, and Online Methods, with topical subheadings in Results and Methods but no subheadings in Discussion. Manuscript must include Methods, figures, Extended Data if applicable, a reference list, names and affiliations of all co-authors unless double-blind peer review is chosen, and documentation of any large language model use in the Methods section or another suitable part of the manuscript.

References References are typically recommended up to 60.

Figures & Tables Display items must total 5–8 figures and/or tables, and a maximum of ten Extended Data display items is permitted.

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Analysis

Cover Letter A cover letter is required. Cover letter must explain the importance of the work, its suitability for Nature Cancer’s diverse readership, and whether there were prior discussions with a Nature Cancer editor.

Abstract An abstract is required. Abstract must be 150 words. Abstract must be unstructured and unreferenced.

Manuscript Main text must be up to 4,000 words, excluding abstract, online Methods, references and figure legends. Manuscript must be divided into an Introduction without a heading, Results, Discussion, and Methods, with topical subheadings in the Results and online Methods and no subheadings in the Discussion. Use of a large language model must be documented in the Methods section or, if no Methods section is available, in a suitable alternative part of the manuscript.

References References are typically recommended up to 60.

Figures & Tables Display items must total 5–8 figures and/or tables.

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Review

Abstract Abstract requirements are not specified.

Manuscript Main text must be 3,500-6,000 words. Review articles must not include original previously unpublished research findings or new research data. Manuscript file must include methods if applicable, figures and Extended Data if applicable, a reference list, and documentation of any large language model use in the Methods section or another suitable part of the manuscript if no Methods section is available.

References References are generally limited to 150 or about 25 references per 1,000 words.

Figures & Tables Display items, including figures, tables, and boxes, must total 4-6 items. A maximum of ten Extended Data display items is permitted.

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Brief Communication

Cover Letter A cover letter is required. Cover letter must explain the importance of the work, why it suits the diverse readership of Nature Cancer, and whether there have been any prior discussions with a Nature Cancer editor about the work.

Abstract An abstract is required. Abstract must be no more than 70 words and limited to 3 sentences. Abstract must be unstructured and unreferenced.

Manuscript Main text must be 1,000-1,500 words including the abstract, references, and figure legends. Manuscript must include a Methods section and contain no headings in the main text. Use of a large language model must be documented in the Methods section or, if no Methods section is available, in a suitable alternative part of the manuscript.

References References are typically recommended up to 20. Article titles must be omitted from the reference list.

Figures & Tables Display items must be limited to 2, although this may be flexible at the editor's discretion if the page limit is observed.

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Resource

Abstract An abstract is required. Abstract must be 150 words. Abstract must be unstructured.

Manuscript Main text must be up to 4,000 words excluding abstract, online Methods, references, and figure legends. Manuscript must be divided into Introduction without a heading, Results, Discussion, and Methods, with Results and Methods divided by topical subheadings and Discussion containing no subheadings. Methods, figures, and Extended Data must be included in the manuscript file if applicable, and any use of a large language model must be documented in the Methods section or a suitable alternative part of the manuscript.

References References are typically recommended up to 60. Abstract must be unreferenced.

Figures & Tables Display items must total 5–8 figures and/or tables, and a maximum of ten Extended Data display items is permitted.

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Correspondence

Cover Letter A cover letter is required. Cover letter must explain the importance of the work, why it is appropriate for the diverse readership of Nature Cancer, and whether there have been any prior discussions with a Nature Cancer editor about the work described in the manuscript.

Abstract Abstract requirements are not specified.

Manuscript Correspondence must be 300–800 words. Use of a large language model must be documented in the Methods section or, if no Methods section is available, in a suitable alternative part of the manuscript.

References References are limited to 10. Reference list entries must omit article titles.

Figures & Tables Display items are limited to 1.

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Recent Publications

Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma

Jack Y. Ghannam, Julian Bryan, Jakob Weiss, Daniel Kovarsky, David Merrell, Conor Messer, Kristy Schlueter-Kuck, Geoffrey G. Fell, Mary Jane Lim-Fat, Gilbert Youssef, Rifaquat Rahman, Lei Qin, Geoffrey S. Young, J. Thomas Janes, McKayla Van Orden, Kathleen L. Pfaff, Andrew Gans, Emma S. Lin, Raymond Y. Huang, Brian P. Danysh, Laxmi Parida, Shuqiang Li, Patrick Y. Wen, E. Antonio Chiocca, Donna Neuberg, Keith L. Ligon, Itay Tirosh, David A. Reardon, Gad Getz, Catherine J. Wu

10.1038/s43018-026-01179-2

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Author Correction: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Selim Chaib, José Alberto López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats, Ines Marin, Olga Boix, Andrea García-Garijo, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Sandra Pérez-Ramos, Marta Escorihuela, Fatima Al-Shahrour, Timothy P. Cash, Tamara Tchkonia, James L. Kirkland, María Abad, Alena Gros, Joaquín Arribas, Manuel Serrano

10.1038/s43018-026-01191-6

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Added value of ctDNA testing with primary treatment for metastatic prostate cancer prognosis

10.1038/s43018-026-01176-5

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Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity

Alan Y. L. Wong, Jacob W. Myers, Gyan Prakash, Alice Ma, Jeannette R. Brook, Boryana Petrova, Baran Bulut, Ralph White, Catherine Merz, Maeve de Souza, Adam G. Maynard, Peng Wang, Amy Yu, Nancy K. Pohl, Michal Weitman, Lewis B. Silverman, Kimberly Stegmaier, L. Stirling Churchman, Peter D. Cole, Donita C. Brady, Naama Kanarek

10.1038/s43018-026-01177-4

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Gemcitabine and nab-paclitaxel with or without the VDR agonist paricalcitol for metastatic pancreatic cancer: a randomized, multiarm, run-in phase trial

Kimberly J. Perez, Andressa Dias Costa, Alexander Jordan, Thomas B. Karasic, Dalia Elganainy, Suryun Kim, Chen Yuan, Dan Y. Gui, Runzi Tan, Sung Chul Hong, Xi Wang, Simona Cristea, Emma Coleman, Morgan Truitt, Tae Gyu Oh, Hui Zheng, C. Sloane Furniss, Lauren Brais, Alexandra Bird, Josh Remland, Vasilena Gocheva, Jennifer S. Thalappillil, Mark Anderson, James M. Cleary, Andrea Enzinger, Marios Giannakis, Kimmie Ng, Douglas A. Rubinson, Benjamin Schlechter, Rishi Surana, Harshabad Singh, Thomas Abrams, Ursina Teitelbaum, Natallia Izgur, Eliezer Allen, Peter S. Winter, Srivatsan Raghavan, Jen Jen Yeh, Daniel Von Hoff, Christopher Liddle, Michael Downes, Ronald M. Evans, Peter O’Dwyer, Andrew Aguirre, Jonathan A. Nowak, Brian M. Wolpin

10.1038/s43018-026-01165-8

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Frequently asked questions

How long does it take to publish?

Research articles are published as soon as they are ready and can appear online weeks before assignment to a specific issue.

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Is a cover letter required?

Reviews and Perspectives are typically invited by the editors, and a presubmission enquiry including a synopsis is advisable before preparing a manuscript for formal submission.

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What are the publication costs?

Some non-primary article types are not eligible for Open Access and can only be published using the subscription-based publishing route.

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Research Topics

Cancer Immunotherapy and Biomarkers Cancer Genomics and Diagnostics CAR-T cell therapy research Immunotherapy and Immune Responses Immune Cell Function and Interaction Epigenetics and DNA Methylation Immune cells in cancer Cancer Cells and Metastasis RNA modifications and cancer Lung Cancer Treatments and Mutations Single-cell and spatial transcriptomics Cancer, Hypoxia, and Metabolism Pancreatic and Hepatic Oncology Research Glioma Diagnosis and Treatment Protein Degradation and Inhibitors Acute Myeloid Leukemia Research T-cell and B-cell Immunology Ferroptosis and cancer prognosis Radiomics and Machine Learning in Medical Imaging AI in cancer detection Cancer Research and Treatments Lung Cancer Research Studies PARP inhibition in cancer therapy Monoclonal and Polyclonal Antibodies Research DNA Repair Mechanisms

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