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Nature Aging

Nature Aging is a journal focused on aging research, publishing article formats including Articles, Analysis, Review Articles, Research Briefings, News & Views, Correspondence and Research Highlights, with a mix of open access and non-open access content.

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Subject Geriatrics & Gerontology, Neurosciences
Impact Factor 19.4
Quartile Q1
Open Access Type Hybrid
eISSN 2662-8465
Invitation Only No
Cost Range English language editing starts at $87. Scientific editing starts at $1545.

Submission Instructions

Nature Aging accepts the following article types. Click on an article type to view submission instructions.

Article

Cover Letter A cover letter is required. Cover letter must explain the importance of the work, explain its suitability for the diverse readership of Nature Aging, disclose any related manuscripts under consideration or in press elsewhere, and state any prior discussions with a Nature Aging editor about the work.
Abstract An abstract is required. Abstract must be up to 150 words, although clinical and public health research Articles may have longer abstracts to accommodate statistical information. Abstract must be unstructured and unreferenced.
Manuscript Main text must be up to 4,500 words, excluding abstract, Methods, references and figure legends. Article must be divided into an Introduction without heading, Results, Discussion and Online Methods, with Results and Online Methods divided by topical subheadings. Manuscript must include Methods, figures and Extended Data if applicable, must contain the names and affiliations of all co-authors unless double-blind peer review is chosen, and any use of a Large Language Model must be documented in the Methods section or another suitable part of the manuscript.
References References are typically recommended up to 60.
Figures & Tables Display items are limited to 8 total figures and/or tables, and a maximum of 10 Extended Data display items is permitted.
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Analysis

Cover Letter A cover letter must be included with the submission. Cover letter should explain the importance of the work, why it is suitable for the journal’s diverse readership, whether there were prior discussions with an editor, and, for double-blind review, provide all authors’ affiliations and contact information.
Abstract An abstract is required. Abstract must be 100–150 words. Abstract must be unstructured and unreferenced.
Manuscript Main text must be up to 4,000 words, excluding the abstract, Online Methods, references and figure legends. Manuscript must be organized as Introduction without heading, Results, Discussion and Online Methods, with Results and Online Methods divided by topical subheadings and no subheadings in the Discussion. Use of a Large Language Model must be documented in the Methods section or, if no Methods section is available, in another suitable part of the manuscript.
References References are typically recommended up to 50.
Figures & Tables Display items are limited to 8 total figures and/or tables.
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Letter

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, explain its suitability for the diverse readership of Nature Aging, and state whether there have been prior discussions with a Nature Aging editor about the work described in the manuscript.
Abstract An abstract is not required because the article instead begins with an introductory paragraph that is part of the main text. The introductory paragraph should be approximately 150 words. The abstract is replaced by an unstructured introductory paragraph that is considered part of the main text.
Manuscript Main text should be approximately 2,500 words, excluding the introductory paragraph, online Methods, references and figure legends. Letters are usually not divided by headings, except for the online Methods headings. The manuscript must open with an introductory paragraph summarizing the background, rationale, main results and implications, and any use of a Large Language Model must be documented in the Methods section or another suitable part of the manuscript if no Methods section is available.
References References are typically recommended up to 40.
Figures & Tables Display items are limited to 4 figures and/or tables.
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Review

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, explain its suitability for the diverse readership of Nature Aging, and state whether there have been prior discussions with a Nature Aging editor about the manuscript.
Abstract Abstract requirements are not specified.
Manuscript Main text should typically be around 5,000 words, with additional flexibility at the editor's discretion. Manuscript must include a detailed description of the findings with sufficient information on methods and materials to enable replication by a fellow expert. Use of a Large Language Model must be documented in the Methods section or, if no Methods section is available, in a suitable alternative part of the manuscript.
References References may include up to 150 entries, with exceptions possible in special cases. Citations should be selective, and short annotations for particularly important studies comprising 10% or less of all references are encouraged.
Figures & Tables A maximum of ten Extended Data display items is permitted. Manuscript file must include figures and Extended Data if applicable. Illustrations are strongly encouraged.
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Primary Research Articles

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, explain its suitability for the diverse readership of Nature Aging, state whether there were prior discussions with a Nature Aging editor, and include author affiliation and contact information if double-blind peer review is chosen.
Abstract Abstract requirements are not specified.
Manuscript No manuscript word, page, or character limit is explicitly stated, but no more than ten Extended Data display items are permitted. Manuscript must include a detailed description of the findings with sufficient information on methods and materials to enable replication, and it must include Methods, Figures, and Extended Data if applicable. Manuscript must contain the names and affiliations of all co-authors unless double-blind peer review is chosen, and any use of a Large Language Model must be documented in the Methods section or another suitable part of the manuscript.
References Manuscript must contain a reference list.
Figures & Tables A maximum of ten Extended Data display items is permitted. Figures and Extended Data must be included in the manuscript file if applicable.
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Original Research Papers

Cover Letter A cover letter is required. Cover letter must explain the importance of the work, explain its suitability for the diverse readership of Nature Aging, state whether there were prior discussions with a Nature Aging editor, and include author affiliation and contact information if double-blind peer review is chosen.
Abstract Abstract requirements are not specified.
Manuscript Manuscript must include a Methods section containing all elements necessary to allow interpretation and replication of the results. Manuscript must include figures and Extended Data if applicable, a reference list, names and affiliations of all co-authors unless double-blind peer review is chosen, and documentation of any Large Language Model use in the Methods section or another suitable part of the manuscript.
References References requirements are not specified.
Figures & Tables A maximum of ten Extended Data display items is permitted. Figures and Extended Data, if applicable, must be included in the manuscript file.
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Brief Communication

Cover Letter A cover letter is required. Cover letter must explain the importance of the work, explain its suitability for the diverse readership of Nature Aging, state any prior discussions with a Nature Aging editor, and include author affiliation and contact information if double-blind peer review is chosen.
Abstract An abstract is required. Abstract must be limited to 3 sentences and no more than 70 words. Abstract must be brief and unreferenced. Abstract must not contain headings.
Manuscript Main text must be 1,500 words including abstract, references and figure legends. Manuscript must contain no headings and must include an Online Methods section. Use of a Large Language Model must be documented in the Methods section or in a suitable alternative part of the manuscript if no Methods section is available.
References References are typically recommended up to 20. Article titles must be omitted from the reference list.
Figures & Tables Display items should be limited to 2–3 items, although this may be flexible at the editor's discretion provided the page limit is observed.
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Resource

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, why it is appropriate for the diverse readership of Nature Aging, and whether there have been prior discussions with a Nature Aging editor about the work described in the manuscript.
Abstract An abstract is required. Abstract must be 100–150 words. Abstract must be unstructured and unreferenced.
Manuscript Main text must be up to 4,500 words, excluding the abstract, Online Methods, references and figure legends. Resource articles must be divided into an unheaded Introduction, Results, Discussion and Online Methods, with Results and Online Methods divided by topical subheadings and no subheadings in the Discussion. Use of a Large Language Model must be properly documented in the Methods section or, if a Methods section is not available, in a suitable alternative part of the manuscript.
References References are typically recommended up to 60.
Figures & Tables Display items, including figures and/or tables, are limited to 8 items. A maximum of 10 Extended Data display items is permitted.
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Correspondence

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, explain its appropriateness for the diverse readership of Nature Aging, state whether there were prior discussions with a Nature Aging editor, and disclose related manuscripts under consideration or in press elsewhere.
Abstract Abstract requirements are not specified.
Manuscript Correspondence should typically be 600 to 1200 words, with flexibility at the editor's discretion. Correspondence must not present original unpublished research findings or research data or analysis and may contain only minimal new supporting data. Use of a Large Language Model must be documented in the Methods section or, if no Methods section is available, in another suitable part of the manuscript.
References References are limited to 10. Reference lists must omit article titles.
Figures & Tables Display items are limited to 1.
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Matters Arising

Cover Letter A cover letter must be included with the submission. The cover letter should explain the importance of the work, why it is appropriate for the diverse readership of Nature Aging, disclose related manuscripts under consideration or in press elsewhere, and state any prior discussions with a Nature Aging editor.
Abstract Abstract requirements are not specified.
Manuscript The manuscript file must include methods, figures, and Extended Data if applicable, and provide sufficient detail on findings, methods, and materials to enable replication by a fellow expert. Use of a Large Language Model must be documented in the Methods section or, if no Methods section is available, in a suitable alternative part of the manuscript.
References References requirements are not specified.
Figures & Tables A maximum of ten Extended Data display items is permitted.
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Recent Publications

Connecting fragmented aging research through the European Federation for Aging Research

Björn Schumacher, Morten Scheibye-Knudsen, Lene Juel Rasmussen, Folkert Kuipers

10.1038/s43587-026-01128-9
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Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization

Victoria Taylor-Bateman, Phazha Bothongo, Venexia Walker, Patrick G. Kehoe, Liv Tybjærg Nordestgaard, Yoav Ben-Shlomo, Neil M. Davies, Dylan M. Williams, Emma L. Anderson

10.1038/s43587-026-01106-1
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p21+TREM2+ senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease

Ivan A. Salladay-Perez, Itzetl Avila, Lizeth Estrada, Andreea C. Alexandru, Cristian Ponce, Anika Dhingra, Grasiela Torres, Christina Y. Deng, Ronak Hegde, Julia Gensheimer, Abhijit Kale, Indra Heckenbach, Simon Hui, Chantle Edillor, Jose A. Soto, Alexander J. Napior, Isaiah Little, Mark Larsen, Jacob Rose, Lia Farahi, Edwin D. J. Lopez Gonzalez, Matthew R. Krieger, Kushan Chowdhury, Mridul Sharma, Yuming Jiang, Kevin Williams, Morten Scheibye-Knudsen, Carla M. Koehler, Jesse G. Meyer, Julia J. Mack, Charles Brenner, Steven J. Bensinger, Cyril Lagger, João Pedro de Magalhães, Birgit Schilling, Rajat Singh, Eric Verdin, Aldons J. Lusis, Anthony J. Covarrubias

10.1038/s43587-026-01101-6
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Astrocyte-based CAR immunotherapy against Alzheimer’s disease

Maria Papatriantafyllou

10.1038/s43587-026-01115-0
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Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging

Manish Mishra, Hee-Hoon Kim, Yun-Hee Youm, Elsie Gonzalez-Hurtado, Konstantin Zaitsev, Tamara Dlugos, Irina Shchukina, Christy Gliniak, Eric Ravussin, Subhasis Mohanty, Albert C. Shaw, Philipp E. Scherer, Maxim N. Artyomov, Vishwa Deep Dixit

10.1038/s43587-026-01107-0
View Publication

Frequently asked questions

How long does it take to publish?

Manuscripts proceed through editorial process and peer review after submission. After acceptance in principle, accepted papers must follow formatting guidelines. Once formally accepted, manuscripts are sent to Production to prepare for publication.

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Is a cover letter required?

A cover letter is required. It should explain the importance of the work and its suitability for the readership, disclose related manuscripts under consideration or in press elsewhere, note any prior discussions with an editor, include author affiliations and contact information for double-blind peer review submissions, and may optionally recommend or exclude reviewers.

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What are the publication costs?

Publishing options and costs are part of the journal's publishing models.

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Research Topics

Genetics, Aging, and Longevity in Model Organisms Alzheimer's disease research and treatments Epigenetics and DNA Methylation Telomeres, Telomerase, and Senescence Neuroinflammation and Neurodegeneration Mechanisms Dementia and Cognitive Impairment Research Single-cell and spatial transcriptomics Health, Environment, Cognitive Aging Circadian rhythm and melatonin Immune cells in cancer Frailty in Older Adults Tryptophan and brain disorders Diet and metabolism studies Mitochondrial Function and Pathology Adipose Tissue and Metabolism Autophagy in Disease and Therapy Dietary Effects on Health Birth, Development, and Health Health disparities and outcomes Gut microbiota and health Aging and Gerontology Research Nutrition and Health in Aging Health Systems, Economic Evaluations, Quality of Life RNA Research and Splicing Immune Cell Function and Interaction

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