MP

Molecular Pharmacology

Molecular Pharmacology publishes findings derived from innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology applied to basic pharmacological problems that provide mechanistic insights broadly important to pharmacology and toxicology. Relevant topics include molecular signaling and mechanism of drug action, chemical biology and drug discovery, structure of drug-receptor complexes, systems analysis of drug action, and drug transport and metabolism.

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Subject Pharmacology & Pharmacy
Impact Factor 3
Quartile Q2
Open Access Type Hybrid
ISSN 0026-895X
eISSN 1521-0111
Invitation Only No
Cost Range Open access APC: USD 3600 excluding taxes; ASPET members receive a 25% discount. Subscription publication has no open access publication fee.

Submission Instructions

Molecular Pharmacology accepts the following article types. Click on an article type to view submission instructions.

Original Research Articles

Cover Letter A letter of submission is required. The cover letter must include a scientific basis for the drug concentration or concentrations used in the experiments.
Abstract An abstract is required for Original Research Articles. Abstract must not exceed 250 words. Abstract must be unstructured and able to stand alone.
Manuscript The Introduction must not exceed 750 words and the Discussion must not exceed 1,500 words. Manuscript must include an Introduction stating the aims or hypotheses, a Materials and Methods section, Results, Discussion, Acknowledgements before the references, and a significance statement immediately after the abstract. Manuscript must include a significance statement of no more than 80 words after the abstract, 3 to 6 English keywords with acronyms and abbreviations spelled out, a declaration of generative AI use before the references, and completion of the declarations tool.
References References must use numbered citations in superscript Arabic numerals in order of appearance. The reference list must be numbered in order of appearance and journal names must be abbreviated according to the List of Title Word Abbreviations.
Figures & Tables Figures must be supplied as separate files, while tables must be submitted as editable text. All figures and tables must be cited in the text, numbered consecutively in order of appearance, and provided with captions.
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Minireviews

Cover Letter A letter of submission is required, and unsolicited Minireviews should be preceded by a presubmission inquiry. Drug concentration justification must be included in the cover letter, and presubmission inquiries for unsolicited Minireviews must include the abstract, significance statement, proposed title, and full author list.
Abstract An abstract is required for Minireviews. Minireview abstracts are limited to 250 words. The abstract must be a single paragraph and able to stand alone without reference to the text. The abstract must indicate the scope of the minireview and summarize the major contents presented.
Manuscript Minireviews should generally range from 4,000 to 6,000 words excluding the reference list. Minireviews should preferably include Introduction, Brief historical perspective, Key recent advances, Current challenges and knowledge gaps, Perspective on future directions, and Conclusions sections. The manuscript must include a separate Significance Statement of no more than 80 words, 3 to 6 English keywords with acronyms and abbreviations spelled out, and a generative AI declaration section before the references if applicable.
References There is no limit to references for Minireviews. References must be cited in the text with superscript Arabic numerals and listed in numerical order of appearance, with journal names abbreviated according to the List of Title Word Abbreviations.
Figures & Tables Figures must be supplied as separate files along with the manuscript, while tables are submitted within the manuscript as editable text. Tables must be editable text and not images, and all figures and tables must be cited in the text, numbered in order of appearance, and provided with captions.
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Letters To The Editor

Cover Letter A letter of submission is required. The cover letter must justify the drug concentration or concentrations used in the experiments.
Abstract Abstract is not required for Letters To The Editor.
Manuscript A declaration of generative AI use in manuscript preparation must be included in a new section before the references list.
References References must use a numbered citation style with superscript Arabic numerals cited in order of appearance. The reference list must be numbered in order of citation, journal names must be abbreviated according to the List of Title Word Abbreviations, and all in-text citations must match the reference list.
Figures & Tables Figures must be uploaded as separate files, while tables are included as editable text. Tables must be numbered consecutively and include captions, and all figures and tables must be cited in the manuscript text.
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Emerging Concepts

Cover Letter A letter of submission is required.
Abstract Abstract must not exceed 250 words.
Manuscript Manuscript may be up to 6,000 words excluding the reference list. Manuscript must describe emergent areas of biochemical and/or molecular biology and must not include data. Manuscript must include 3 to 6 English keywords with any acronyms or abbreviations spelled out, and any use of generative AI in manuscript preparation must be declared in a new section placed before the references list.
References References must be cited with superscript Arabic numerals in order of appearance, and the reference list must be numbered in that same order with journal names abbreviated according to the List of Title Word Abbreviations.
Figures & Tables Figures must be supplied as separate files along with the manuscript, while tables are uploaded with the submission as editable text. Tables must be submitted as editable text rather than images and must include captions.
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Recent Publications

Regulation of organic anion transporting polypeptide 1B1 Transport Function by Lysine Deacetylase 6

Vikram Aditya, Vishakha Tambe, Pascaline Niyonshuti, Ruhul Kayesh, Erik J. Soderblom, Xiaohong Mary Zhang, Chao Xu, Wei Yue

10.1016/j.molpha.2026.100132
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Molecular Pharmacology of mGlu7/8 Heterodimers Reveals Unique Properties of Orthosteric Agonists and Positive Allosteric Modulators

Anthony S. Ferranti, Youhyun Noh, Xia Lei, Xin Lin, Joseph D. Bungard, Wesley B. Asher, Jonathan A. Javitch, Colleen M. Niswender

10.1016/j.molpha.2026.100133
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Effects of ivermectin on the activation and desensitization of the human GABAA receptor

Spencer R. Pierce, Allison L. Germann, Ka Tak Tsoi, Gustav Akk

10.1016/j.molpha.2026.100134
View Publication

Where are peptide ligands of potassium channels sourced from?

Alexey I. Kuzmenkov, Alexander A. Vassilevski

10.1016/j.molpha.2026.100135
View Publication

Maraviroc alleviates neuropathic pain symptoms in a mouse model of spared nerve injury

Wei Zhao, Cigdem Sevim Bayrak, Fiona Chen, Hsiao-Yun Lin, Bin Zhang, Jun Wang

10.1016/j.molpha.2026.100126
View Publication

Frequently asked questions

How long does it take to publish?

43 days from submission to decision after review; 110 days from submission to acceptance.

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Is a cover letter required?

A letter of submission is included in the submission checklist. Presubmission inquiries must include a cover letter with the manuscript type, abstract, significance statement, and full author information. Drug concentration justification should be included in both the cover letter and the manuscript text.

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What are the publication costs?

Open access APC is USD 3600 excluding taxes. Subscription publication has no open access publication fee.

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Research Topics

Receptor Mechanisms and Signaling Neuroscience and Neuropharmacology Research Ion channel regulation and function Neuropeptides and Animal Physiology Nicotinic Acetylcholine Receptors Study Diverse Scientific and Economic Studies Drug Transport and Resistance Mechanisms Pharmacogenetics and Drug Metabolism Adenosine and Purinergic Signaling Protein Kinase Regulation and GTPase Signaling Human auditory perception and evaluation Educational Robotics and Engineering Neurotransmitter Receptor Influence on Behavior Cardiac electrophysiology and arrhythmias Estrogen and related hormone effects Nitric Oxide and Endothelin Effects Chemical Synthesis and Analysis Cancer therapeutics and mechanisms Pharmacological Receptor Mechanisms and Effects Biochemical and Molecular Research Amino Acid Enzymes and Metabolism Eicosanoids and Hypertension Pharmacology HIV/AIDS drug development and treatment DNA and Nucleic Acid Chemistry Hormonal Regulation and Hypertension

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