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Nature Reviews Disease Primers

Nature Reviews Disease Primers publishes authoritative disease-focused Primer and PrimeView articles, along with Editorial, Comment and Correspondence content, covering epidemiology, pathophysiology, diagnosis, treatment, management and patient quality of life across a wide range of medical conditions.

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Subject Medicine, General & Internal
Impact Factor 60.6
Quartile Q1
Open Access Type Hybrid
ISSN 2056-676X
eISSN 2056-676X
Invitation Only Yes
Cost Range No fee for publication.

Submission Instructions

Nature Reviews Disease Primers is an invitation-only journal. Submissions are accepted by invitation from the editorial board only. The following article types are accepted:

Primer

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract should be unstructured and ideally no more than 200 words. Abstract must be unstructured.
Manuscript Manuscript must use the major headings in this order: Introduction, Epidemiology, Mechanisms/pathophysiology, Diagnosis, screening and prevention, Management, Quality of life, and Outlook. Manuscript must include an end-of-Introduction scope statement, at least one figure in the Mechanisms/pathophysiology section, competing interests declarations in the manuscript text, and documentation of any LLM use in the Methods section or another suitable section if no Methods section is available.
References References should be approximately 25 per 1,000 words, and highlighted references should comprise 5–10% of the total references. References must use Nature Reviews style. References must be cited as sequential superscript numbers and listed in the order of main text, tables, figures, and then boxes, with six or more authors shortened to the first author followed by 'et al.'.
Figures & Tables At least one display item must be included per section, and the Mechanisms/pathophysiology section must include at least one figure. Tables and boxes must be provided as part of the article document, whereas tables containing graphical content must be provided as separate image files. Figures must be fully labelled with a short title and concise legend, and tables must have a short title, no legend, and definitions for all abbreviations.
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Disease Primer

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract should be unstructured and ideally no more than 200 words. Abstract must be unstructured.
Manuscript Manuscript must use the fixed major headings in this order: Introduction, Epidemiology, Mechanisms/pathophysiology, Diagnosis, screening and prevention, Management, Quality of life, and Outlook. Manuscript must include an end-of-Introduction scope statement, at least one figure in the Mechanisms/pathophysiology section, competing interests declarations in the manuscript text, and any LLM use documented in the Methods section or a suitable alternative section.
References References should be approximately 25 per 1,000 words, with highlighted references comprising 5–10% of the total. References must use Nature Reviews style. References must be cited as sequential superscript numbers and listed in the order of main text, tables, figures, and then boxes, with six or more authors shortened to the first author followed by 'et al.'.
Figures & Tables The manuscript must include at least 1 display item per section and the Mechanisms/pathophysiology section must include at least one figure. Tables must be provided as part of the article document, while tables containing graphical content must be provided as separate image files. Figures must be fully labelled with a short title and concise legend, and tables must have a short title, no legend, entries in all cells, and all abbreviations defined.
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Correspondence

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Use of a large language model must be documented in the Methods section or, if no Methods section is present, in another suitable part of the manuscript.
References References requirements are not specified.
Figures & Tables Figures & Tables requirements are not specified.
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Recent Publications

Post-traumatic stress disorder

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10.1038/s41572-026-00709-7
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Post-traumatic stress disorder

Kerry J. Ressler, Barbara O. Rothbaum, Paula P. Schnurr, Elisabeth B. Binder, Alisha Moreland-Capuia, Caroline M. Nievergelt, Karestan C. Koenen, Soraya Seedat, Arieh Shalev, Charles R. Marmar, Ronald C. Kessler

10.1038/s41572-026-00701-1
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Pancreatic cancer

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10.1038/s41572-026-00708-8
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Pancreatic cancer

Susanne Roth, Minoti Apte, Vinod P. Balachandran, Giulia Biffi, Thierry Conroy, Edna Cukierman, Efrat Dotan, Irene Esposito, Barbara T. Grünwald, Miriam Klauß, Alison P. Klein, Núria Malats, Eileen M. O´Reilly, Mike J. Pishvaian, Francisco X. Real, Dieter Saur, Jens T. Siveke, Christoph W. Michalski

10.1038/s41572-026-00699-6
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Necrotizing enterocolitis

David J. Hackam, Neena Modi, Jan Hulscher, Elisabeth M. W. Kooi, Asuka Ishiyama

10.1038/s41572-026-00698-7
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Research Topics

Autoimmune Bullous Skin Diseases Liver Disease Diagnosis and Treatment Renal Diseases and Glomerulopathies Systemic Lupus Erythematosus Research Lymphoma Diagnosis and Treatment Metabolism and Genetic Disorders Diet and metabolism studies Glioma Diagnosis and Treatment Neuroendocrine Tumor Research Advances Congenital Diaphragmatic Hernia Studies Coagulation, Bradykinin, Polyphosphates, and Angioedema Urticaria and Related Conditions Sarcoma Diagnosis and Treatment Helicobacter pylori-related gastroenterology studies Liver Disease and Transplantation Pituitary Gland Disorders and Treatments Diabetes and associated disorders Parkinson's Disease Mechanisms and Treatments Child and Adolescent Psychosocial and Emotional Development Shoulder Injury and Treatment Gastrointestinal motility and disorders Hemoglobinopathies and Related Disorders Diabetes Management and Research Aortic Disease and Treatment Approaches Genetic Neurodegenerative Diseases

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