Overview
Submission Instructions
Recent Publications
Frequently Asked Questions
Research Topics
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OS
Ophthalmology Science is an online open access journal focused on publishing pre-clinical development, phase 1 and 2 clinical trials, laboratory-based work, ophthalmology informatics, and clinical science.
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Subject
Ophthalmology
Impact Factor
4.6
Quartile
Q1
Open Access Type
Open
ISSN
2666-9145
eISSN
2666-9145
Invitation Only
No
Cost Range
USD 2500 excluding taxes for all articles; 20% discount for corresponding authors who are members of the American Academy of Ophthalmology.
Submission Instructions
Ophthalmology Science accepts the following article types. Click on an article type to view submission instructions.
Manuscripts
Cover Letter
Cover letters are required for all new or transferred submissions. The cover letter must justify deletion of any required abstract section.
Abstract
A structured abstract is required. Abstract must not exceed 350 words. Abstract must be structured in seven required sections and submitted on a separate page in the manuscript file. Abstract must include Objective or Purpose, Design, Subjects/Participants/Controls, Methods/Intervention/Testing, Main Outcome Measures, Results, and Conclusions.
Manuscript
Discussion must be the final section of the manuscript, and a separate conclusion section must not be included. The manuscript submission must include a separate précis of 35 words or fewer summarizing the main finding or outcome in complete unbulleted sentences without duplicating the abstract conclusion, the title page must include 3 to 5 key words, and any use of generative AI or AI-assisted technologies in writing must be declared in a section placed before the references.
References
The manuscript file must contain no more than 50 references. References must be in AMA style. References must be cited in the text using consecutive superscript Arabic numerals in the order of appearance.
Figures & Tables
Figures and tables must not be embedded in the manuscript file and must be submitted as separate files. Figure legends must be submitted separately from figure files, and tables must be built in Microsoft Word with one table per file or combined in a single Word file.
Systematic Review
Cover Letter
Cover letter is required for new or transferred submissions. Cover letter must state whether reporting guidelines were followed and which were used, and whether the exact full search strategy for at least one database was presented in an appendix with enough detail to permit replication.
Abstract
Structured abstract is required. Abstract must not exceed 350 words. Abstract must be structured into five sections. Abstract must include the headings Topic, Clinical relevance, Methods, Results, and Conclusion, and must include the registration number.
Manuscript
Manuscript text must be divided into Introduction, Methods, Results, and Discussion, and the Methods section must include the subheadings Eligibility criteria for considering studies for this review, Search methods for identifying studies, Study selection, Data collection and risk of bias assessment, and Data synthesis and analysis. Manuscript must include a précis of 35 words or fewer submitted as a separate file rather than in the manuscript, 3 to 5 key words on the title page, and a declaration of generative AI and AI-assisted technologies in the writing process at the end of the manuscript before the references if such tools were used.
References
Manuscript file must contain no more than 50 references. References must be in AMA style. References must be cited in the text using consecutive superscript Arabic numerals in order of appearance.
Figures & Tables
Figures and tables must not be embedded in the manuscript file and must be submitted as separate files. Tables must include titles, a brief description, and footnotes, and figure legends must be included at the end of the manuscript file and submitted in a single Word document file.
Meta-Analysis
Cover Letter
Cover letters are required for new or transferred submissions. Cover letter must state whether reporting guidelines were followed and which guidelines were used, and whether the exact full search strategy for at least one database was presented in an appendix with sufficient detail to permit replication.
Abstract
A structured abstract is required. Abstract must not exceed 350 words. Abstract must be structured into five sections. Abstract must include the headings Topic, Clinical relevance, Methods, Results, and Conclusion.
Manuscript
Manuscript text must be divided into Introduction, Methods, Results, and Discussion, with the Methods section including Eligibility criteria for considering studies for this review, Search methods for identifying studies, Study selection, Data collection and risk of bias assessment, and Data synthesis and analysis. Manuscript must include a 35-word-or-fewer précis submitted as a separate file, a title that identifies the report as a systematic review, meta-analysis, or both in the subtitle, 3 to 5 key words on the title page, and a Declaration of Generative AI and AI-assisted technologies in the writing process section before the references if such tools were used.
References
Manuscript file must contain no more than 50 references. References must be in AMA style. References must be cited in the text using consecutive superscript Arabic numerals in the order of appearance.
Figures & Tables
Figures and tables must not be embedded in the manuscript file and must be submitted as separate files. Tables must be built in Microsoft Word and uploaded as individual Word documents with one table per file, and figure legends must be submitted in a single Word document file rather than included in print figure files.
Aao Meeting Paper
Cover Letter
Cover letter is required for new or transferred submissions. Cover page must note that the submission is derived from an Annual Meeting paper or poster, and any deletion of a required abstract section must be justified in the cover letter.
Abstract
A structured abstract is required and must be submitted on a separate page in the manuscript file. Abstract must not exceed 350 words. Abstract must be structured. Abstract must include Objective or Purpose, Design, Subjects/Participants/Controls, Methods/Intervention/Testing, Main Outcome Measures, Results, and Conclusions.
Manuscript
Discussion must be the final section of the manuscript, and a separate conclusion section must not be included. Manuscript must include a précis of 35 words or fewer summarizing the main finding or outcome in complete unbulleted sentences, submitted as a separate file rather than in the manuscript, and if generative AI or AI-assisted technologies were used in writing, a declaration section must appear at the end of the manuscript before the references.
References
Reference list must contain no more than 50 references. References must be in AMA style. References must be cited in the text using consecutive superscript Arabic numerals in the order of appearance, and all references must be cited in the text.
Figures & Tables
Figures and tables must not be embedded in the manuscript file and must be submitted as separate files. Tables must be built in Microsoft Word with one table per file or in a single Word file, and figure legends must be submitted in a single Word document rather than included in print figure files.
Correspondence
Cover Letter
Cover letters are required for new or transferred correspondence submissions. Cover letters must confirm that the work has not been published previously, is not under consideration elsewhere, and has been approved by all authors and responsible authorities.
Abstract
An abstract is required.
Manuscript
Correspondence is limited to 700 words. Correspondence must begin with 'To the Editor,' use the title format 'Re: [last name of first author of published article] et al.: [title of the published article to which the Correspondence refers],' and end with the name, degree, and location for each author. Correspondence should address no more than three points, must reference the article being commented on in the first paragraph as the first listed reference, and must include a 'Declaration of Generative AI and AI-assisted technologies in the writing process' section before the references if AI-assisted writing was used.
References
Correspondence may include no more than 5 references, including the article to which the authors are responding. References must be in AMA style. The article being commented on must be cited in the first paragraph and listed as reference 1, and references must be cited in the text using consecutive superscript Arabic numerals in order of appearance.
Figures & Tables
Figures, tables, and graphs are typically not included. Figures and tables must not be embedded in the manuscript and must be submitted as separate files.
Translational Science Reviews
Cover Letter
Cover letters are required for all new or transferred submissions. Cover letter must confirm that the work has not been published previously, is not under consideration elsewhere, and has been approved by all authors and responsible authorities where the work was carried out.
Abstract
An abstract is required. Abstract must not exceed 350 words. Abstract must be unstructured.
Manuscript
Discussion must be the final section of the manuscript, and a separate conclusion section must not be included. Manuscript must include 3 to 5 key words on the title page, a précis of 35 words or less, and if generative AI or AI-assisted technologies were used in writing, a declaration section before the references titled 'Declaration of Generative AI and AI-assisted technologies in the writing process'.
References
Manuscript file must contain no more than 50 references. References must be in AMA style format. References must be cited in the text using consecutive superscript Arabic numerals in the order in which they appear.
Figures & Tables
Figures and tables must not be embedded in the manuscript file and must be submitted as separate files. Figure legends must be submitted separately with legends for print figures included at the end of the manuscript file or in a single Word document, and each table must be submitted as an individual Word file with its legend within the table.
Report-Invited
Cover Letter
Cover letter is required. Cover letter must include the manuscript number of the original submission and a point-by-point response to the original reviewers' questions and suggestions.
Abstract
A 35-word unstructured abstract is required for editors' and reviewers' view only and will not be published with the report. Abstract must not exceed 35 words. Abstract must be unstructured. No abstract headings are required.
Manuscript
Report must not exceed 1000 words. Text must be in narrative rather than structured format. Manuscript must include 3 to 5 key words on the title page, a précis of 35 words or less, and a Declaration of Generative AI and AI-assisted technologies in the writing process at the end of the manuscript before the references if such technologies were used.
References
Report must not include more than 7 references. References must be in AMA style. References must be cited in the text using consecutive superscript Arabic numerals in the order of appearance.
Figures & Tables
Report may include one figure, graph, chart, or concise table in the main manuscript and up to three additional items as supplemental material. Figures and tables must not be embedded in the manuscript file and must be submitted as separate files. Reports must be double-spaced.
Report-Unsolicited
Cover Letter
Cover letters are required for all new or transferred submissions. Cover letters must confirm that the work has not been published previously, is not under consideration elsewhere, and has been approved by all authors and responsible authorities where the work was carried out.
Abstract
A 35-word unstructured abstract is required for editors' and reviewers' view only and will not be published with the report. Abstract must not exceed 35 words. Abstract must be unstructured.
Manuscript
Report must not exceed 1000 words. Text must be double-spaced and written in narrative rather than structured format. Manuscript must include 3 to 5 key words on the title page, a précis of 35 words or less, and a declaration of generative AI and AI-assisted technologies in the writing process if such tools were used.
References
Report must not include more than 7 references. References must be in AMA style. References must be cited in the text as consecutive superscript Arabic numerals in the order of appearance.
Figures & Tables
Report may include one figure, graph, chart, or concise table in the main manuscript and up to three additional items as supplemental material. Figures and tables must not be embedded in the manuscript file and must be submitted as separate files. Figure legends must be submitted in a single Word document, tables must be built in Microsoft Word, and embedded table images must not be used.
Data Science
Cover Letter
Cover letter is required. Cover letter must state that the work should be evaluated under the Data Science article category.
Abstract
Abstract is required.
Manuscript
Discussion must be the final section of the manuscript, and a separate conclusion section must not be inserted. Manuscript must include a separate précis of 35 words or fewer summarizing the main finding or outcome in complete unbulleted sentences without duplicating the abstract conclusion, and if generative AI or AI-assisted technologies were used in writing, it must include a declaration section before the references.
References
Manuscript file must contain no more than 50 references. References must be in AMA style. References must be cited in the text using consecutive superscript Arabic numerals in the order of appearance.
Figures & Tables
Figures and tables must not be embedded in the manuscript file and must be submitted as separate files. Figure legends must be submitted in a single Word document file, tables must be built in Microsoft Word, and each table must include titles or legends and footnotes.
Recent Publications
Deep Learning–Derived Retinal Age Detects Cognitive Impairment
Minkyu Kim, Kenneth Um, Gui-Shuang Ying, Benjamin J. Kim
10.1016/j.xops.2026.101274
View Publication
Age- and Myopia-Related Three-Dimensional Remodeling of Choroidal Thickness in Children
Luxiao Chen, Jixuan Yuan, Ziyao Wang, Zhe Pan, Dan Zhu, Zeyue Fan, Di Zhang, Ziyao Xia, Jost B. Jonas, Chong Li, Tien Yin Wong, Ya Xing Wang
10.1016/j.xops.2026.101273
View Publication
Test-retest repeatability of a novel photopic microperimetry approach in patients with geographic atrophy
Neha R. Tandon, Eric Vasquez, Karl G. Csaky
10.1016/j.xops.2026.101267
View Publication
Early Prediction of Diabetic Macular Edema via Machine Learning Survival Analysis on Checkup Data
Yusuke Kashiwagi, Katsuyuki Chida, Ayaka Hananoe, Ryoichi Ishibashi, Masaya Koshizaka, Yoshiro Maezawa, Yosuke Inaba, Yoko Takatsuna, Tomoaki Tatsumi, Hiroko Inoue, Hanae Wakabayashi, Tetsuo Ishikawa, Akiko Hanai, Koutaro Yokote, Katsuhiko Asanuma, Eiryo Kawakami
10.1016/j.xops.2026.101262
View Publication
Baseline OCT Biomarkers Associated with the 2-year Development of Macular Atrophy or Fibrosis in Neovascular AMD
Chiara Olivieri, Giacomo Perin, Xuenan Zhuang, Giovanni Neri, Guglielmo Parisi, Paola Marolo, Pasquale Viggiano, Francesco Boscia, Michele Reibaldi, Enrico Borrelli
10.1016/j.xops.2026.101268
View Publication
Frequently asked questions
How long does it take to publish?
12 days submission to first decision; 55 days submission to decision after review; 134 days submission to acceptance; 8 days acceptance to online publication.
Reformat to Ophthalmology Science using Livewrite PremiumIs a cover letter required?
Cover letters are required for all new or transferred submissions. The cover letter should note prior submission to this or another journal, include manuscript numbers when applicable, and provide any additional information for the editorial board or editorial office.
Reformat to Ophthalmology Science using Livewrite PremiumWhat are the publication costs?
Article Publishing Charge: USD 2500 excluding taxes for all articles. A 20% discount is available for corresponding authors who are members of the American Academy of Ophthalmology.
Reformat to Ophthalmology Science using Livewrite PremiumResearch Topics
Retinal Diseases and Treatments
Ophthalmology and Visual Impairment Studies
Retinal Imaging and Analysis
Glaucoma and retinal disorders
Corneal surgery and disorders
Retinal and Macular Surgery
Retinal Development and Disorders
Ocular Diseases and Behçet’s Syndrome
Retinal and Optic Conditions
Retinopathy of Prematurity Studies
Ocular Surface and Contact Lens
Corneal Surgery and Treatments
Diverse Scientific and Economic Studies
Intraocular Surgery and Lenses
Ocular Oncology and Treatments
Artificial Intelligence in Healthcare and Education
Optical Coherence Tomography Applications
Ocular Infections and Treatments
Human auditory perception and evaluation
Educational Robotics and Engineering
Ferroelectric and Negative Capacitance Devices
Big Data and Digital Economy
Connexins and lens biology
Ocular Disorders and Treatments
Cerebral Venous Sinus Thrombosis