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Toxicological Sciences

Toxicological Sciences is a community-facing journal and the official journal of the Society of Toxicology. It publishes toxicology research and offers an Oxford Open option for immediate open access publication upon payment of a charge.

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Subject Toxicology
Impact Factor 4.1
Quartile Q1
Open Access Type Hybrid
ISSN 1096-6080
eISSN 1096-0929
Invitation Only No
Cost Range There is usually an Article Processing Charge (APC) for publication in fully open access journals, and authors choosing gold open access in hybrid journals usually pay an APC.

Submission Instructions

Toxicological Sciences accepts the following article types. Click on an article type to view submission instructions.

Original Research Article

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required for an Original Research Article. Abstract must not exceed 250 words. Abstract must be unstructured and contain no subheadings. Abstract must include introductory statement(s) explaining the rationale and hypothesis, a concise summary of the results, and an Impact Statement at the end of the abstract.
Manuscript Introduction must not exceed 750 words and Discussion must not exceed 1,500 words. Manuscript must include a Title Page, Abstract, Introduction, Materials and Methods, Results, Discussion, Data links, COI, Funding, Acknowledgements, and a Reference List. Title page must include 3 to 6 keywords and a running head of no more than 60 characters, and the manuscript must include an Impact Statement, a COI statement, a Funding section, Data links, and alt text under each figure legend.
References References must follow CSE Author-Date 29.3.3 style. Reference list must include deposited datasets with an accession number or unique identifier such as a DOI, and citations to preprints, meeting abstracts, and presentations are not allowed.
Figures & Tables Tables must be placed at the end of the main manuscript, while supplementary material must be submitted in separate files. Tables must be editable and include a title and legend, and figures must be numbered consecutively with legends and include alt text directly under the relevant figure legend.
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Contemporary Review

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required. Abstract must not exceed 250 words. Abstract must be unstructured with no subheadings. Abstract must explain why the topic is important to toxicology, highlight major recent findings, provide suggestions for future research, and end with a one- to two-sentence Impact Statement on why the review is important and how it moves the field forward.
Manuscript Manuscript must not exceed 4,000 words in total, including a Future Directions section of no more than 500 words. Manuscript must include a Title Page, Abstract, Introduction, Review of the literature, Conclusions, Future Directions, Data links, COI, Funding, and Acknowledgements. Title must not exceed 12 words, the text must be understandable to a non-specialist, and the title page must include 3 to 6 keywords.
References Contemporary Review should include approximately 75 references, with most published within the last 5 years. References must follow CSE Author-Date 29.3.3 style. References may be formatted in any standard style at submission, but cited items must be peer-reviewed PubMed-listed journal articles and citations to preprints or meeting abstracts are not allowed.
Figures & Tables Submission should include two to four summary figures, diagrams, or tables to convey key messages. Tables must appear at the end of the main manuscript in editable format. Alt text must be provided in the main manuscript directly under each relevant figure legend.
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In-Depth Review

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required. Abstract must not exceed 250 words. Abstract must be unstructured with no subheadings. Abstract must succinctly summarize the review topic and its importance to toxicology, highlight major recent consistencies and inconsistencies in the field, provide suggestions for future research, and include an Impact Statement explaining why the review is important and how it moves the field forward.
Manuscript Manuscript must not exceed 12,000 words in total, including a Future Directions section of no more than 500 words. Manuscript must include a Title Page, Abstract, Introduction, Review of the literature, Conclusions, Future Directions, Data links, COI, Funding, Acknowledgements, and a description of search terms and inclusion criteria. Abbreviations and acronyms are limited to genes and proteins, and the review should include two to four summary figures, diagrams, or tables to convey key messages.
References Review should include approximately 200 references, with most from the last 10 years. References must follow CSE Author-Date 29.3.3 style. References must cite peer-reviewed journals from the PubMed journal list, and preprints and meeting abstracts or presentations are not allowed.
Figures & Tables Review should include two to four summary figures, diagrams, or tables. Tables must be placed at the end of the main manuscript in editable format. Figures and tables must be numbered consecutively and include legends, and alt text must be provided in the main manuscript directly under each relevant figure legend.
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Systematic Review

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must be unstructured and contain no subheadings.
Manuscript Manuscript must include an Introduction with objectives, rationale, and a PECO, PECOTs, or other appropriate framework, a Methods section covering the protocol, team expertise, search and study identification processes, eligibility criteria, data extraction, appraisal and bias evaluation, and evidence synthesis methods, Results reporting study selection, evidence tables, qualitative characterization, and synthesis and integration, and a Discussion summarizing evidence and conclusions related to the PECO and addressing uncertainty and limitations. Manuscript must include an impact statement of 1–2 concise descriptive sentences, acknowledgements or disclosures including financial and non-financial conflicts, and an explanation in the Methods section if any required systematic review elements were not identified or implemented.
References References must follow CSE Author-Date 29.3.3 style. References must cite peer-reviewed journals from the PubMed journal list, and citations to preprints and meeting abstracts or presentations are not allowed.
Figures & Tables Tables must be placed at the end of the main manuscript in editable format. Figures must include alt text directly under the relevant figure legend in the main manuscript, and tables must be numbered consecutively and include a title and legend.
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Systematic Maps

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must be unstructured and contain no subheadings.
Manuscript Manuscript must include 3 to 6 keywords on the title page, a Funding section and a conflict of interest statement at the end of the text, and a 1-2 sentence impact statement.
References References must follow CSE Author-Date 29.3.3 style. References may be formatted in any standard style at submission, and cited articles must be from peer-reviewed journals on the PubMed journal list with preprints and meeting abstracts or presentations not allowed.
Figures & Tables Tables must be placed at the end of the main manuscript, while supplementary material must be submitted in separate files. All images, figures, illustrations, and photographs must include alt text directly under the relevant figure legend in the main manuscript file, and tables must be created in an editable word processing format with titles and legends.
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Research Brief

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required for a Research Brief. Abstract must not exceed 250 words. Abstract must be unstructured with no subheadings.
Manuscript Text including abstract and figure or table legends must not exceed 2500 words. Manuscript must include a Title Page, Abstract, Introduction, Methods, Results/Conclusions, conflict of interest statement(s), Funding, Acknowledgements, and a Reference list, and it must not use Introduction, Methods, Results, or Discussion subheadings. Manuscript must include an impact statement of 1–2 sentences and 3 to 6 keywords on the title page.
References Reference list must not contain more than 35 references. References must follow CSE Author-Date 29.3.3 style. References may be formatted in any standard style at submission, and cited articles must be peer-reviewed PubMed-listed journal articles with no preprints or meeting abstracts/presentations cited.
Figures & Tables No more than 4 total tables and figures with legends are allowed. Tables must be placed at the end of the main manuscript in editable format. All images, figures, illustrations, and photographs must include alt text directly under the relevant figure legend in the main manuscript file.
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Letters To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Letters to the Editor must not exceed 1,000 words. Letters to the Editor must include a descriptive title. An impact statement of 1-2 concise and meaningful sentences is required.
References Letters to the Editor may include no more than 8 references. References must follow CSE Author-Date 29.3.3 style. References may be formatted in any standard style at submission, but cited articles must be from peer-reviewed journals on the PubMed journal list and citations to preprints, meeting abstracts, and presentations are not allowed.
Figures & Tables Tables must be placed at the end of the main manuscript in editable format. Alt text must be included directly under the relevant figure legend in the main manuscript file for all images, figures, illustrations, and photographs.
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Recent Publications

The International Collaborative Animal Study of mobile phone radiofrequency radiation carcinogenicity and genotoxicity: the Japanese study

Katsumi Imaida, Mayumi Kawabe, Jianqing Wang, Masanao Yokohira, Norio Imai, Kang-Hyun Han, Yong-Bum Kim, Sang Bong Jeon, Hye Sun Kim, Young Hwan Ahn

10.1093/toxsci/kfag002
View Publication

The International Collaborative Animal Study of the carcinogenicity and genotoxicity of mobile phone radiofrequency radiation: the Korean study

Hye Sun Kim, Kang-Hyun Han, Yong-Bum Kim, Sang Bong Jeon, Ae-Kyoung Lee, Jung-Ick Moon, Hyung Do Choi, Katsumi Imaida, Masanao Yokohira, Mayumi Kawabe, Norio Imai, Jianqing Wang, Young Hwan Ahn

10.1093/toxsci/kfag001
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In memoriam: James E. Gibson (1941–2025)

Jay I Goodman, James S Bus

10.1093/toxsci/kfaf180
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β-lactoglobulin–per- and polyfluoroalkyl substance-binding interactions identifies the calyx domain as a determinant of contaminated milk exposure and the calycin protein family as potential mediators of per- and polyfluoroalkyl substance toxicity

Zachary S McLean, Mallory E Thomas, Scott M Belcher

10.1093/toxsci/kfaf178
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Quantitative adverse outcome pathway modeling of cisplatin-induced nephrotoxicity: developing in vitro and in vivo models for predictive extrapolation

Filippo Di Tillio, Lukas S Wijaya, Steven J Kunnen, Carl Joshua Eugenio, Giorgio Buzzanca, Imke B Bruns, Marvin Martens, Nynke I Kramer, Jesper Kers, Giulia Callegaro, Bob van de Water, Joost B Beltman

10.1093/toxsci/kfaf177
View Publication

Frequently asked questions

How long does it take to publish?

Median days from submission to first decision, median days from submission to final decision, and median days from acceptance to publication are used as peer review and production metrics.

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What are the publication costs?

There is usually an Article Processing Charge (APC) for publication in fully open access journals, and authors choosing gold open access in hybrid journals usually pay an APC.

Reformat to Toxicological Sciences using Livewrite Premium

Research Topics

Carcinogens and Genotoxicity Assessment Effects and risks of endocrine disrupting chemicals Toxic Organic Pollutants Impact Pesticide Exposure and Toxicity Air Quality and Health Impacts Heavy Metal Exposure and Toxicity Animal testing and alternatives Pharmacogenetics and Drug Metabolism Drug Transport and Resistance Mechanisms Environmental Toxicology and Ecotoxicology Drug-Induced Hepatotoxicity and Protection Immunotoxicology and immune responses Trace Elements in Health Computational Drug Discovery Methods Estrogen and related hormone effects Diverse Scientific and Economic Studies Genomics, phytochemicals, and oxidative stress Neuroscience and Neuropharmacology Research Pesticide and Herbicide Environmental Studies Per- and polyfluoroalkyl substances research Arsenic contamination and mitigation Birth, Development, and Health Human auditory perception and evaluation Retinoids in leukemia and cellular processes Glutathione Transferases and Polymorphisms

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