CR

Cancer Research

The Journal of Hepatocellular Carcinoma is an international, peer-reviewed, open access journal that publishes clinical, translational, and basic research on hepatocellular carcinoma, including signaling pathways, molecular tumor classification, therapies, radiology, epidemiology, surveillance, prevention, and quality of life.

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Subject Oncology
Impact Factor 16.6
Quartile Q1
Open Access Type Open
ISSN 0008-5472
eISSN 1538-7445
Invitation Only No
Cost Range Publication involves a base publication fee and an additional fee for each display item; authors may apply for a waiver of the fixed publication fee if no financial support exists.

Submission Instructions

Cancer Research accepts the following article types. Click on an article type to view submission instructions.

Original Research Articles

Cover Letter Cover letter is strongly encouraged for initial submission. Cover letter must describe how any associated manuscript is related to the current submission.
Abstract Abstract is required.
Manuscript Initial submissions do not have strict length restrictions, and the methods section is excluded when calculating manuscript length. Manuscript must be arranged in the following order: title page, text and references, tables, figure legends, and figures. Manuscript must include a conflict of interest disclosure on the title page, a Data Availability subsection at the end of the Materials and Methods or Methods section titled "Data Availability," an Acknowledgments section including funding and any generative AI or other contributors, and a Code Availability Statement if custom computer code was used.
References References must be numbered in order of first mention in the text, cited in the text by number only, and list all authors if there are 6 or fewer or the first 6 authors followed by et al. if there are more than 6.
Figures & Tables For initial submission, figures and tables should be included in a single manuscript file with each figure presented in sequence adjacent to its legend, while supplementary data must be uploaded separately. Each figure must have a legend with a short title sentence and description, multi-panel figures must have labeled panels described in the legend, figure legends must include the number of technical and biological replicates, and tables must have descriptive titles and be numbered with Arabic numerals.
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Review Manuscript

Cover Letter Cover letter is strongly encouraged for initial submission.
Abstract Abstract is required.
Manuscript Initial submissions do not have strict length restrictions, and the methods section is excluded when calculating manuscript length. Manuscript must be arranged in the following order: title page, text and references, tables, figure legends, and figures. The manuscript must include a conflict of interest disclosure on the title page, a Data Availability subsection at the end of Materials and Methods, acknowledgments of funding and nonauthor contributors, and declarations of any generative AI use in the acknowledgments or other appropriate section.
References References must be numbered in the order of first mention and cited in the text by number only. List all authors when a reference has 6 or fewer authors, but for more than 6 authors list the first 6 followed by et al.
Figures & Tables For initial submission, figures and tables should be included in a single manuscript file with each figure presented in sequence adjacent to its legend, while supplementary data must be uploaded separately. Each figure must have a legend with a short title and description, multi-panel figures must have labeled panels described in the legend, and figure legends must include the number of technical and biological replicates.
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Meta-Analysis

Cover Letter Cover letter is strongly encouraged for initial submission. Cover letter must describe how any associated manuscript is related to the current submission.
Abstract Abstract is required.
Manuscript Initial submissions do not have strict length restrictions, and the methods section is excluded when calculating manuscript length. Manuscript must be arranged in the order of title page, text and references, tables, figure legends, and figures. The manuscript must include a conflict of interest disclosure statement on the title page, a Data Availability subsection at the end of the Materials and Methods or Methods section, an acknowledgment of any generative AI or editing services in the Acknowledgments section, and a declaration of any AI-produced material in an appropriate section of the manuscript.
References References must be numbered in order of first mention in the text, cited by number only, and list all authors if there are 6 or fewer or the first 6 authors followed by et al. if there are more than 6.
Figures & Tables For initial submission, figures and tables should be included in a single manuscript file with each figure presented in sequence adjacent to its legend, while supplementary data must be uploaded separately. Each table must have a descriptive title and Arabic numeral, and each figure must have a legend with a short title sentence and panel descriptions if applicable.
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Systematic Reviews

Cover Letter Cover letter is strongly encouraged for initial submission. Cover letter must describe how any associated manuscript is related to the current submission.
Abstract Abstract is required.
Manuscript Initial submissions do not have strict length restrictions, and the methods section is excluded when calculating manuscript length. Manuscript must be arranged in the following order: title page, text and references, tables, figure legends, and figures. Manuscript must include a conflict-of-interest disclosure statement on the title page, a Data Availability subsection at the end of the Materials and Methods, and a declaration of any generative artificial intelligence or human-assisted editing contribution in the acknowledgments or other appropriate section.
References References must be numbered in order of first mention in the text, cited by number only, and list all authors for references with 6 or fewer authors or the first 6 authors followed by et al. for references with more than 6 authors.
Figures & Tables For initial submission, figures and tables should be included in a single manuscript file with each figure presented in sequential order adjacent to its legend, while supplementary data must be uploaded separately. Each table must have a descriptive title and Arabic numeral, and each figure must be cited in order and accompanied by a legend that identifies all panels, symbols, and replicate numbers.
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Recent Publications

MEKing Room: On the Quest for New Sources of Therapeutic Index in RAS/MAPK-Driven Cancers

Bijaya Gaire, Poulikos I. Poulikakos

10.1158/0008-5472.can-26-2050
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ARID2 Loss Reprograms the Kynurenine-AhR Pathway to Restore Antitumor Immunity in CTNNB1-Mutant Hepatocellular Carcinoma

Qianyu Li, Yunfeng Yuan, Ning Liu, Linfeng Li, Yifei Qian, Fan Wang, Songling Li, Wenli Qin, Quankun Lin, Hongmin Lu, Yuliang Rao, Qiang Xia, Yanan Wang, Yanfeng Liu

10.1158/0008-5472.can-26-0860
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ACKR3 Establishes a Squamous-Restricted Immune Checkpoint Axis in Lung Squamous Cell Carcinoma

Angeliki Karatza, Kaan Kumru, Jaylen M. Powell, Chengwei Peng, Yuan Hao, Metamia Ciampricotti, Dimitris Nasias, Hai Hu, Muhammad Elnaggar, Maayan Pour, Alison Chafitz, Yeuan Ting Lee, Priyanka Sahu, Yi Jer Tan, Yun Xue, Ruveyda Ayasun, Alfonso Lopez, Magdalena A. Ploszaj, Daniel Andrussier, Yun Zhang, Fiona Sherman, Cynthia A. Loomis, Peter Meyn, Jonathan So, Salman R. Punekar, Rajwanth Veluswamy, James A. Wells, Dafna Bar-Sagi, Kwok-Kin Wong

10.1158/0008-5472.can-25-5347
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A syngeneic murine glioma model recapitulates key molecular, immunologic, and functional features of human glioblastoma to enable therapeutic development

Katie B. Grausam, Marissa S. Pioso, Julio C. Sanchez, Marissa Li, David Rincon Fernandez Pacheco, Emily A. Hatanaka, Gilbert Herrera, Thomas J. Lai, Eddie Lu, Paul W. Linesch, Naomi Kobritz, Trinh L. Phan, Sophie Ashley, Ariel A. Andrade, Lauren Markus, Jingwen Yao, Xuemo Fan, Bohyeon Yu, Aaron A. Diaz, Linda M. Liau, Moise Danielpour, David A. Nathanson, Robert M. Prins, Joshua J. Breunig, Stephen L. Shiao

10.1158/0008-5472.can-25-5766
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A Germline-Encoded lncRNA-Mitochondrial Axis Rewires Oxidative Phosphorylation to Drive Progression in Clear Cell Renal Cell Carcinoma

Guowen Duan, Wenjie Xu, Wenjun Jiang, Linhui Zhang, Yi Lin, Cheng Lian, Qin Zhang, Zixian Wang, Zenglai Tan, Zixi Wang, Shengjie Zhai, Qi Liu, Aki Manninen, Ying Lu, Zhao Zhang, Yuanyuan Qu, Gong-Hong Wei

10.1158/0008-5472.can-25-5866
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Frequently asked questions

How long does it take to publish?

Is a cover letter required?

A cover letter is strongly encouraged for initial submission.

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What are the publication costs?

Publication involves a base publication fee and an additional fee for each display item. Authors may apply for a waiver of the fixed publication fee if no financial support exists.

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Research Topics

Cancer Genomics and Diagnostics Cancer, Hypoxia, and Metabolism RNA modifications and cancer Cancer Research and Treatments Cancer Immunotherapy and Biomarkers Cancer Cells and Metastasis Cancer-related Molecular Pathways Advanced Breast Cancer Therapies Cancer-related molecular mechanisms research Breast Cancer Treatment Studies Epigenetics and DNA Methylation Monoclonal and Polyclonal Antibodies Research Cancer, Lipids, and Metabolism HER2/EGFR in Cancer Research Immunotherapy and Immune Responses Ferroptosis and cancer prognosis Prostate Cancer Treatment and Research CAR-T cell therapy research Cancer Treatment and Pharmacology Lung Cancer Treatments and Mutations Estrogen and related hormone effects Ubiquitin and proteasome pathways Nanoplatforms for cancer theranostics Protein Degradation and Inhibitors Molecular Biology Techniques and Applications

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