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Clinical Chemistry

Clinical Chemistry is a journal published by Oxford University Press for the Association for Diagnostics & Laboratory Medicine in the field of laboratory medicine and clinical chemistry. The journal features research articles, clinical case studies, special issues, podcasts, and other scholarly content, and lists a 2024 Impact Factor of 6.3 with a ranking of 1/33 in Medical Laboratory Technology.

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Subject Medical Laboratory Technology
Impact Factor 6.3
Quartile Q1
Open Access Type Hybrid
ISSN 0009-9147
eISSN 1530-8561
Invitation Only No
Cost Range No submission fee. Open access publication is available for an open access charge after acceptance. Print color figures cost $820 per figure; online-only color is free.

Submission Instructions

Clinical Chemistry accepts the following article types. Click on an article type to view submission instructions.

Article

Cover Letter Cover letter is required only for expedited submission of an Article previously peer reviewed by another prominent journal. For expedited submission previously peer reviewed by another prominent journal, the cover letter must verify that communications with the prior journal are not under a nondisclosure or confidentiality agreement and that all prior journal emails and reviewer comments have been provided intact and unedited, and it must disclose any use of artificial intelligence to help generate content, write code, or process data.
Abstract A structured abstract is required. Abstract must be limited to 250 words. Abstract must be structured. Abstract must use the headings Background, Methods, Results, and Conclusions.
Manuscript Main text excluding abstract and references must not exceed 3,500 words. Text should be formatted with the headings Introduction, Methods, Results, and Discussion. Submission must include keywords on the first page, a Brief Summary of no more than 100 words addressing the paper’s rationale, approach, findings, and implications and including a simple phonetic spelling of the first author’s full name, and alt text descriptions in the main manuscript file directly under each relevant figure legend.
References No more than 40 references are permitted. In-text citations must use numbered references in the form (1) or (1, 2), and references must be listed and numbered in order of appearance with the first six authors followed by et al. when there are more than seven authors.
Figures & Tables No more than 6 tables and/or figures in total are permitted. Tables must be embedded directly following the reference section, while all figures must be uploaded separately as image files and not embedded in the manuscript file. Each table must appear on an individual page and be labeled and numbered consecutively, and figure legends must be listed together on an individual page directly following the tables or the references if there are no tables.
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Comprehensive Review

Cover Letter Use of artificial intelligence to help generate content, write code, or process data must be disclosed in the cover letter. The cover letter must disclose any use of artificial intelligence to help generate content, write code, or process data.
Abstract A structured abstract is required. Abstract must not exceed 250 words. Abstract must be structured. Abstract must use the headings Background, Content, and Summary.
Manuscript Text must not exceed 5,000 words. Text should be formatted with the headings Introduction, Methods, Results, and Discussion. The first page must include keywords, word count, number of figures and tables, and a list of abbreviations, and alt text descriptions must be included in the main manuscript file directly under the relevant figure legend.
References Submissions must have no more than 75 references. References must be numbered in order of appearance with in-text citations formatted as numbered parentheses, and for more than seven authors list the first six followed by et al.
Figures & Tables Submissions must include no more than 6 tables and/or figures in total. Tables must be embedded directly after the references, and figures must be uploaded separately as image files. Figure legends must be provided together on a separate page and tables must be numbered consecutively with Arabic numerals.
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Clinical Case Study

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not be included.
Manuscript Case description and case discussion are limited to 1,500 words total, excluding the questions and points to remember. Manuscript must include a case description followed by a case discussion. Manuscript must include 3–5 brief questions regarding the case, up to 5 points to remember at the end, and the case title, case description, and questions must not disclose the diagnosis.
References References are limited to 10. References must be numbered in order of appearance in the text using numbered in-text citations formatted as (1) or (1, 2).
Figures & Tables Tables and figures are limited to a combined total of 2. Tables must be embedded directly after the references, figure legends must follow the tables or references, figures must be uploaded separately, and supplemental data are not permitted.
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Letter To The Editor

Cover Letter Any use of artificial intelligence to help generate content, write code, or process data must be disclosed in the cover letter.
Abstract Abstract must not be included.
Manuscript Manuscript must not exceed 750 words. Text should be formatted with the headings Introduction, Methods, Results, and Discussion. The first page must include keywords, word count, number of figures and tables, and a list of abbreviations, and the manuscript should list no more than 8 authors.
References References are limited to 5. References must be numbered in the order cited and formatted as numbered in-text citations such as (1) or (1, 2), listing all authors if there are 7 or fewer or the first 6 followed by et al. if there are more than 7.
Figures & Tables Only 1 table or figure may be included. Tables must be embedded directly after the references, figures must be uploaded separately, and supplemental data are not permitted. The single table or figure must not be multipart.
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Mini-Review

Cover Letter Cover letter must disclose any use of artificial intelligence to help generate content, write code, or process data. Cover letter must include disclosure of any use of artificial intelligence to help generate content, write code, or process data.
Abstract Abstract is required and must be structured for Mini-Review submissions. Abstract must not exceed 250 words. Abstract must be structured. Abstract must use the headings Background, Content, and Summary.
Manuscript Text must not exceed 3,500 words. Text should be formatted with the headings Introduction, Methods, Results, and Discussion. The first page must include keywords, word count, number of figures and tables, and a list of abbreviations in order cited.
References Mini-Review submissions must have no more than 40 references. References must be numbered in the order cited, use numbered in-text citations in parentheses, and list the first six authors followed by et al. when there are more than seven authors.
Figures & Tables Mini-Review submissions must include no more than 4 tables and/or figures in total. Tables must be embedded directly after the references, and figures must be uploaded separately as image files. Figure legends must be listed on a separate page after the tables or references, and alt text for each figure must be included in the main manuscript directly under the relevant figure legend.
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Clinical Toxicology Series

Cover Letter Use of artificial intelligence to help generate content, write code, or process data must be disclosed in the cover letter.
Abstract An abstract must be supplied during online submission.
Manuscript Manuscript must include a case description of no more than 75 words and a case discussion of no more than 250 words. Manuscript must include a case description, 3 questions, and a case discussion. The first page must include keywords, word count, number of figures and tables, and a list of abbreviations in order cited.
References References must not exceed 5. References must be numbered in order of appearance and cited in text as numbered citations in parentheses.
Figures & Tables Tables must be embedded directly after the references, figure legends must follow the tables or references, figures must be uploaded separately, and supplemental data are not permitted. Each table and figure must be clearly labeled and numbered consecutively, and alt text for each image must be included in the main manuscript directly under the relevant figure legend.
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Special Report

Cover Letter Use of artificial intelligence to help generate content, write code, or process data must be disclosed in the cover letter. Cover letter must disclose any use of artificial intelligence to generate content, write code, or process data.
Abstract Special Report submissions must include an abstract. Abstract must not exceed 250 words. Abstract may be structured or unstructured.
Manuscript Main text must not exceed 5,000 words. Text should be formatted with the headings Introduction, Methods, Results, and Discussion. Title page must include keywords, word count, number of figures and tables, a list of abbreviations, and any previous presentation of the manuscript.
References References must not exceed 40. References must be numbered in the order cited, cited in text as numbered parentheses, and list the first six authors followed by et al. when there are more than seven authors.
Figures & Tables Special Report submissions may include no more than 4 tables and/or figures in total. Tables must be embedded directly after the references, figure legends must follow the tables or references, and figures must be uploaded separately. Each table and figure must be clearly labeled and numbered consecutively, and figure legends should be limited to 60 words.
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Editorial

Cover Letter Use of artificial intelligence to help generate content, write code, or process data must be disclosed in the cover letter. The cover letter must disclose any use of artificial intelligence to help generate content, write code, or process data.
Abstract Abstract is not permitted.
Manuscript Manuscript must not exceed 1,500 words. Editorial-specific structural format is not stated. Keywords must be included on the first page.
References References are limited to 15. References must be numbered in the order cited and formatted to match numbered in-text citations.
Figures & Tables Tables and figures are not permitted.
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Recent Publications

Biological Variation of Natriuretic Peptides and Other Cardiovascular Disease-Related Biomarkers: A Systematic Review and Meta-analysis

Pilar Fernández-Calle, Jorge Díaz-Garzón, Bill Bartlett, Abdurrahman Coskun, Anna Carobene, Elisabeth González-Lao, Fernando Marqués-García, Berta Sufrate-Vergara, Isabel Moreno-Parro, Kornelia Galior, Denis İlhan Topcu, Sverre Sandberg, Aasne K Aarsand

10.1093/clinchem/hvag051
View Publication

Establishment of Pseudovirus-Based Reference Materials and Nationwide External Quality Assessment for Arboviruses during the 2025 Chikungunya Outbreak

Ying Yan, Xinru Liu, Shana Halemubieke, Le Chang, Huimin Ji, Huizhen Sun, Yali Zhang, Cong Jin, Lei Zhao, Zhongli Du, Han Ma, Jie Ma, Lunan Wang

10.1093/clinchem/hvag050
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High Concordance between ddPCR- and NGS-Based Quantification of Donor-Derived Cell-Free DNA Percentage after Kidney Transplantation

Marvin Reineke, Lisa Loi, Iris Schröter, Martin Zeier, Julia Beck, Ekkehard Schütz, Brock L Schweitzer, Michael Oellerich, Aylin Akifova, Klemens Budde, Thuong Hien Tran, Christian Morath, Louise Benning

10.1093/clinchem/hvag056
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Enhancing Next-Generation Sequencing Sensitivity with High-Recovery Adapter Ligation and Cas9-Mediated Dimer Elimination

Hwayeon Jeong, Hana Kim, Eunyoung Cho, Hee Kyung Lee, Do Yeon Kim, Bora Keum, Cheulhee Jung

10.1093/clinchem/hvag052
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Standardization Challenges in Glycated Albumin Measurement: Methodological Heterogeneity and Quantification Discrepancies

Hao Zheng, Rui Wu, Li Zhang, Chuanbao Zhang, Tianjiao Zhang

10.1093/clinchem/hvag055
View Publication

Frequently asked questions

How long does it take to publish?

For 2022, original research articles had a median time from submission to first editor decision of 1.5 days, median time from submission to final decision of acceptance of 93.4 days, median time from submission to final decision of rejection of 12.0 days, and median time from submission to online publication of 138.4 days.

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Is a cover letter required?

A cover letter is required for submissions involving preprints, must disclose AI use, and must include prior journal decision materials and verification statements for certain expedited submissions. For What Is Your Guess?, the cover letter must state interest in contributing to that category.

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What are the publication costs?

Subscription journal with open access publishing options.

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Research Topics

Metabolism and Genetic Disorders Clinical Laboratory Practices and Quality Control Metabolomics and Mass Spectrometry Studies Renal function and acid-base balance Neonatal Health and Biochemistry Analytical Chemistry and Chromatography Monoclonal and Polyclonal Antibodies Research Lipoproteins and Cardiovascular Health Molecular Biology Techniques and Applications Diabetes, Cardiovascular Risks, and Lipoproteins Folate and B Vitamins Research Analytical Methods in Pharmaceuticals Hemoglobinopathies and Related Disorders Acute Myocardial Infarction Research Mass Spectrometry Techniques and Applications Thyroid Disorders and Treatments Antibiotics Pharmacokinetics and Efficacy Advanced Biosensing Techniques and Applications Advanced Proteomics Techniques and Applications Hormonal and reproductive studies Cancer Genomics and Diagnostics Health Sciences Research and Education Iron Metabolism and Disorders Radiopharmaceutical Chemistry and Applications Blood groups and transfusion

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