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Clinical Chemistry and Laboratory Medicine (CCLM)

Clinical Chemistry and Laboratory Medicine (CCLM) is the official journal of the European Federation of Clinical Chemistry and Laboratory Medicine and publishes English-language articles on basic and applied research, novel teaching and training methods, and cutting-edge clinical laboratory medicine. It is published monthly in print and online, uses single-anonymized peer review by at least two experts, and covers topics across clinical biochemistry, genomics and molecular biology, hematology and hemostasis, immunology, microbiology, biomarkers, standardization, patient safety, and translational laboratory medicine.

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Subject Medical Laboratory Technology
Impact Factor 3.7
Quartile Q1
Open Access Type Hybrid
ISSN 1434-6621
eISSN 1437-4331
Invitation Only No
Cost Range No submission and publication fee; optional open access under CC-BY-4.0 may be available with no APC or a discount through participating institutions

Submission Instructions

Clinical Chemistry and Laboratory Medicine (CCLM) accepts the following article types. Click on an article type to view submission instructions.

Original Article

Cover Letter Cover letter should include a statement that the paper has not been previously published elsewhere, is not under consideration by another journal, and whether there are any conflicts of interest.
Abstract Abstract requirements are not specified.
Manuscript Manuscript should include relevant keywords.
References References requirements are not specified.
Figures & Tables Each submitted image or illustration must have a unique caption.
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Research Article

Cover Letter Cover letter should be included. Cover letter should state that the paper has not been previously published elsewhere or under consideration by another journal and should declare whether there are any conflicts of interest.
Abstract Abstract is required.
Manuscript Manuscript should include relevant keywords.
References References requirements are not specified.
Figures & Tables Each submitted image or illustration must have a unique caption.
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Review

Cover Letter Cover letter should state that the paper has not been previously published elsewhere, is not under consideration by another journal, and declare whether there are any conflicts of interest.
Abstract Abstract requirements are not specified.
Manuscript Manuscript should include relevant keywords.
References References requirements are not specified.
Figures & Tables Each submitted image or illustration must have a unique caption.
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Mini Review

Cover Letter Cover letter should state that the paper has not been previously published elsewhere and is not under consideration by another journal, and it should declare whether there are any conflicts of interest.
Abstract Abstract is required.
Manuscript Manuscript should include relevant keywords.
References References requirements are not specified.
Figures & Tables Each submitted image or illustration must have a unique caption.
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Letter To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Manuscript requirements are not specified.
References References requirements are not specified.
Figures & Tables Figures & Tables requirements are not specified.
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Guidelines And Recommendations

Cover Letter Cover letter should include a statement that the paper has not been previously published elsewhere, is not under consideration by another journal, and declares whether there are any conflicts of interest. Cover letter should state that the paper has not been previously published elsewhere, is not under consideration by another journal, and declare any conflicts of interest.
Abstract Abstract is required.
Manuscript Manuscript should include relevant keywords.
References References requirements are not specified.
Figures & Tables Each image or illustration must have a unique caption.
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Short Communication

Cover Letter Cover letter should state that the paper has not been previously published elsewhere and is not under consideration by another journal, and it should declare whether there are any conflicts of interest.
Abstract Abstract requirements are not specified.
Manuscript Manuscript should include relevant keywords.
References References requirements are not specified.
Figures & Tables Each submitted image or illustration must have a unique caption.
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Case Report

Cover Letter Cover letter should declare any conflicts of interest.
Abstract Abstract is required.
Manuscript Manuscript should include relevant keywords.
References References requirements are not specified.
Figures & Tables Each image or illustration must have a unique caption.
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Case Report And Review Of The Literature

Cover Letter Cover letter should include statements on exclusive submission and any conflicts of interest. Cover letter should state that the paper has not been previously published elsewhere, is not under consideration by another journal, and whether there are any conflicts of interest.
Abstract Abstract is required.
Manuscript Relevant keywords should be included.
References References requirements are not specified.
Figures & Tables Each submitted image or illustration must have a unique caption.
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Case Series

Cover Letter Cover letter should include a statement that the paper has not been previously published elsewhere and is not under consideration by another journal. Cover letter should state that the paper has not been previously published elsewhere or under consideration by another journal and should declare whether there are any conflicts of interest.
Abstract Abstract is required.
Manuscript Manuscript should include relevant keywords.
References References requirements are not specified.
Figures & Tables Each submitted image or illustration must have a unique caption.
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Case Report - Lessons In Clinical Reasoning

Cover Letter Cover letter should include statements that the paper has not been previously published elsewhere or submitted elsewhere and should declare any conflicts of interest. Cover letter should state that the paper has not been previously published elsewhere or submitted elsewhere and should declare whether any conflicts of interest exist.
Abstract Abstract is required.
Manuscript Manuscript should include relevant keywords.
References References requirements are not specified.
Figures & Tables Each submitted image or illustration must have a unique caption.
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Case Report - Learning From Tragedy

Cover Letter Cover letter should include statements that the paper has not been previously published elsewhere or submitted elsewhere and whether there are any conflicts of interest. Cover letter should state that the paper has not been previously published elsewhere or under consideration by another journal and should declare any conflicts of interest.
Abstract Abstract is required.
Manuscript Relevant keywords should be included.
References References requirements are not specified.
Figures & Tables Each image or illustration must have a unique caption.
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Recent Publications

Frontmatter

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10.1515/cclm-2026-frontmatter7
View Publication

Analytical and clinical performance of the updated Elecsys Anti-TPO II assay for the detection of antibodies against thyroid peroxidase to aid in the diagnosis of autoimmune thyroid diseases

Kenneth D. Burman, Lowell R. Schmeltz, Yoko Momoyama, Feyza Erenler, Samer Nakhle, Fabian A. Mendoza-Ballesteros, Arvind Krishna, Meera Amar, David G. Robertson, Catherine Anastasopoulou, Mark A. Lupo, Michael H. Shanik, John Y. Jun, Trisha D. Cubb, Olga Senashova, Andrew J. Behnke, David Brodbeck, Sandra Yasavul, Peter Dilba, Oliver Lorenz, Johanna Sillman, Peter Findeisen

10.1515/cclm-2026-0044
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Methodology and quality assurance practices in performing anti-extractable nuclear antigen (ENA) analysis: an EFLM report on an international survey

Eva Gijbels, Stijn De Koninck, Sylvia Broeders, Edward K.L. Chan, Nicola Bizzaro, Dimitrios P. Bogdanos, Luis Andrade, Wim Coucke, Wilson de Melo Cruvinel, Ana Kozmar, Liisa Kuhi, Laurence Lutteri, Maria Jose Rego de Sousa, Jan Damoiseaux, Sofie Schouwers, Lieve Van Hoovels, Xavier Bossuyt, Martine Vercammen, Carolien Bonroy

10.1515/cclm-2026-0273
View Publication

Application and developing various evaluation indicators for validating the effectiveness of the harmonisation protocol in multiple scenarios and applying to a multi-center real-world cohort

Xue Yuan, Wei Zhang, Xiaoling Wang, Xiaocui Wu, Lirong Liu, Hua Chen, Wei Lu, Huifang Zhou, Ximing Yang, Penghui Zhang, Feng Gu, Zhiwu Dong, Xin Chang, Xinxin Ren, Manman Zhang, Wenqing Chu, Xiyang Lin, Yuqing Zhu, Zhengrong Zhong

10.1515/cclm-2026-0053
View Publication

Plasma proteomics: considerations for preanalytical variability; a systematic review with narrative synthesis

Conor L. Vaughan, Amna Samjeed, Deirdre M. Murray, Seán J. Costelloe

10.1515/cclm-2026-0330
View Publication

Frequently asked questions

How long does it take to publish?

Is a cover letter required?

Many journals ask for a cover letter to accompany submission. The cover letter should highlight the findings, the impact of the research, why the work is of interest to the journal’s readers, state that the paper has not been previously published elsewhere and is not under consideration by another journal, and declare any conflicts of interest.

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What are the publication costs?

No submission and publication fee; optional open access under CC-BY-4.0 may be available with no APC or a discount through participating institutions

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Research Topics

Clinical Laboratory Practices and Quality Control Metabolism and Genetic Disorders Meta-analysis and systematic reviews Folate and B Vitamins Research Monoclonal and Polyclonal Antibodies Research Renal function and acid-base balance Hemodynamic Monitoring and Therapy Diverse Scientific and Economic Studies Diabetes, Cardiovascular Risks, and Lipoproteins Metabolomics and Mass Spectrometry Studies Acute Myocardial Infarction Research Statistical Methods in Clinical Trials Sepsis Diagnosis and Treatment Liver Disease Diagnosis and Treatment Neonatal Health and Biochemistry Hemoglobinopathies and Related Disorders Iron Metabolism and Disorders Lipoproteins and Cardiovascular Health German Literature and Culture Studies Human auditory perception and evaluation Diabetes Management and Research Thyroid Disorders and Treatments Bacterial Identification and Susceptibility Testing Blood groups and transfusion Advanced Proteomics Techniques and Applications

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