CS

Clinical Science

Clinical Science links basic science to disease mechanisms and focuses on translational research.

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Subject Medicine, Research & Experimental
Impact Factor 7.7
Quartile Q1
Open Access Type Hybrid
ISSN 0143-5221
eISSN 1470-8736
Invitation Only No
Cost Range No APCs are available in Clinical Science; fee-free open access may be available through Read & Publish agreements, and green open access is available.

Submission Instructions

Clinical Science accepts the following article types. Click on an article type to view submission instructions.

Research Papers

Cover Letter Cover letter should highlight the study findings, the advance it brings, and its relevance to the field, and must state if the submission extends preliminary work or work previously presented in abstract form.
Abstract Abstract is required and must not include references. Abstract must not exceed 250 words.
Manuscript Research Papers should be approximately 10–15 pages. Main text must include Introduction, Methods, Results, and Discussion, with the Methods included in the main text file and containing enough detail for independent replication. Manuscript must include a Clinical Perspectives summary section as three bullet-pointed sentences on why the study was undertaken, a brief summary of the results, and the potential significance to human health and disease, and it must include a Data Availability Statement immediately after the Conclusions in the main text, while any AI use for writing, editing, or data work must be disclosed in the Materials and Methods or a similar section.
References There is no limit on the number of references. References must use Vancouver style. References must be numbered consecutively in the text and listed in numerical order, with the first six authors followed by 'et al' when a reference has more than six authors, and DOI included where possible.
Figures & Tables Figures may be embedded in the main text or uploaded as separate files, while control experiments must be included in the main manuscript and should appear within the figures of the main article rather than in supplementary material. Figures and tables must each have a title and legend where appropriate, all figures must be cited in the main text, microscopy images should include a scale bar, and composite figures must have dividing lines and be identified in the figure legend.
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Review Articles

Cover Letter Cover letter should highlight the findings of the study, the advance it brings, and its relevance to the field.
Abstract An abstract is required. Abstract must not exceed 250 words.
Manuscript Review Articles are usually 6,000–8,000 words excluding references and figure legends. Review Articles should be full-length reviews of broad interest. Any use of AI to aid writing or editing or data collection and analysis must be disclosed in the Materials and Methods section or a similar section, and authors must provide keywords during submission.
References There is no limit on the number of references included in Review Articles. References must use Vancouver style. References must be numbered consecutively in the text and listed in numerical order, with the first six authors followed by 'et al' when there are more than six authors.
Figures & Tables Review Articles should include at least one figure. Figures may be embedded into the main text or provided as separate files. All figures and tables must include a title and legend where appropriate, and all figures must be referred to in the main text.
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Research Articles

Cover Letter Cover letter should highlight the study findings, the advance made, and the work's relevance to the field.
Abstract An abstract is required. Abstract must not exceed 250 words.
Manuscript Main text must include Introduction, Methods, Results, and Discussion sections. Manuscript must include a Clinical Perspectives summary as three bullet-pointed sentences covering why the study was undertaken, a brief summary of the results, and the potential significance to human health and disease, and AI use for writing, editing, or data collection or analysis must be disclosed in the Methods section or similar section.
References There is no limit on the number of references. References must use Vancouver style. References must be numbered consecutively in the text, listed in numerical order, and for works with more than six authors the first six names should be followed by 'et al'.
Figures & Tables Figures may be embedded in the main text or uploaded as separate files. Figures and tables must each include a title and legend where appropriate, figures must be cited in the main text, and control experiments must be included in the main manuscript figures rather than supplementary material.
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Correspondence

Cover Letter Cover letter should highlight the findings of the study, the advance it brings, and its relevance to the field.
Abstract Abstract must not exceed 250 words.
Manuscript There is no set length for correspondence. There is no set format for correspondence. Any use of AI to aid writing or editing or data collection and analysis must be disclosed in the Materials and Methods section or a similar section, and all methods must be included in the main article file.
References There is no limit on the number of references. References must use Vancouver style. References must be numbered consecutively in the text and listed in numerical order, and for works with more than six authors the first six names must be listed followed by 'et al'.
Figures & Tables Figures may be embedded into the main text or provided as separate files. All figures and tables must include a title and legend where appropriate, and figures must be referred to in the main text.
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Comments

Cover Letter Cover letter should highlight the findings of the study, the advance it brings, and its relevance to the field.
Abstract Abstract must not exceed 250 words.
Manuscript There is no set length for correspondence. There is no set format for correspondence. Any use of AI to aid writing or editing must be disclosed in the Materials and Methods section or a similar section, stating which tool was used and how it was used.
References There is no limit on the number of references. References must use Vancouver style. References must be numbered consecutively in the text and listed in numerical order, and references with more than six authors must list the first six followed by 'et al'.
Figures & Tables Figures may be embedded into the main text or provided as separate files. All figures and tables must include a title and legend where appropriate, and all figures must be referred to in the main text.
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Letters To The Editor

Cover Letter Cover letter should highlight the findings of the study, the advance it brings, and its relevance to the field.
Abstract Abstract must not exceed 250 words.
Manuscript There is no set length for correspondence. There is no set format for correspondence. Any use of AI to aid writing or editing must be disclosed in the Materials and Methods section or a similar section, stating which tool was used and how it was used.
References There is no limit on the number of references. References must use Vancouver style. References must be numbered consecutively in the text, listed in numerical order, and for works with more than six authors only the first six names should be given followed by 'et al'.
Figures & Tables Figures may be embedded in the main text or uploaded as separate files. Figures and tables must each include a title and legend where appropriate, and figures must also be referred to in the main text.
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Recent Publications

Glomerulus-Targeted Nanotherapy via Collagen IV-α3 Binding Enhances Renal Immunoregulation in Lupus Nephritis

Lei Wang, Eleni Markoutsa, Rajkumar Venkatadri, Rahul Sharma, Carlos Esquivel, Akshata Patne, Jin Wei, Jie Zhang, Kristof Williams, William Lawless, Amtul Muskan, Liying Fu, Karthick Mayilsamy, Subhra Mohapatra, Shyam Mohapatra, Ruisheng Liu

10.1042/cs20261409
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Correction: Cyclin B1 protects against meniscal extracellular matrix catabolism and degeneration via the NOD-like receptor pathway

Hong Guan, Jiangwen Cheng, Xinghong Yuan, Daozhang Cai, Haiyan Zhang, Liangliang Liu

10.1042/cs20260446_cor
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Expression of Concern: Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

Marta B. Afonso, Pedro M. Rodrigues, Tânia Carvalho, Marta Caridade, Paula Borralho, Helena Cortez-Pinto, Rui E. Castro, Cecília M.P. Rodrigues

10.1042/cs20140732_eoc
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Aberrant absorptive enterocyte differentiation is associated with altered ion transport and chronic inflammatory diahrea in IBD patients

Katerina Nikolovska, Evaldas Tytmonas, Anna E Seidler, Gabriella di Stefano, Timo Hellms, Ursula Seidler

10.1042/cs20261278
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Deletion of Nephrocystin-4 Exacerbates Kidney and Cardiac Function in Mice Cardiorenal Syndrome Model via the Interaction with Itch E3 ligase

Yoichiro Otaki, Junya Sato, Tetsu Watanabe, Tomohiro Takehara, Yuzuka Kuramasu, Ryuhei Yamaguchi, Hiroe Ono, Shingo Tachibana, Jun Goto, Hiroki Takahashi, Takanori Arimoto, Kazunobu Ichikawa, Haruki Ochi, Tsuneo Konta, Masafumi Watanabe

10.1042/cs20262448
View Publication

Frequently asked questions

How long does it take to publish?

Median time from submission to first decision in 2024 following full peer review: 39 days. Median time from acceptance to online Version of Record publication in 2024: 15 days.

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Is a cover letter required?

Cover letters are encouraged for all research and review article submissions. If the cover letter includes reviewer suggestions and exclusions, these must also be entered in the submission system. If data sharing is not applicable, the cover letter should explain why.

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What are the publication costs?

No APCs are available in Clinical Science; fee-free open access may be available through Read & Publish agreements.

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Research Topics

Heart Rate Variability and Autonomic Control Nitric Oxide and Endothelin Effects Cardiovascular and exercise physiology Diet and metabolism studies Hormonal Regulation and Hypertension Renin-Angiotensin System Studies Blood Pressure and Hypertension Studies Liver Disease Diagnosis and Treatment Electrolyte and hormonal disorders Adipose Tissue and Metabolism Renal function and acid-base balance Cardiovascular Function and Risk Factors Muscle metabolism and nutrition Asthma and respiratory diseases Cardiovascular Health and Disease Prevention Chronic Obstructive Pulmonary Disease (COPD) Research Birth, Development, and Health Metabolism and Genetic Disorders Pregnancy and preeclampsia studies Receptor Mechanisms and Signaling Heart Failure Treatment and Management Ion Transport and Channel Regulation Adipokines, Inflammation, and Metabolic Diseases Liver Disease and Transplantation Eicosanoids and Hypertension Pharmacology

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