Overview
Submission Instructions
Recent Publications
Frequently Asked Questions
Research Topics
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Molecular Therapy is a peer-reviewed journal focused on gene transfer, vector development and design, stem cell manipulation, gene-, peptide-, protein-, oligonucleotide-, and cell-based therapeutics, vaccine development, pre-clinical target validation, safety and efficacy studies, and clinical trials. It publishes research, reviews, and commentaries in genetics, medicine, and biotechnology and is published for the American Society for Gene and Cell Therapy by Elsevier.
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Impact Factor
12
Quartile
Q1
Open Access Type
Hybrid
ISSN
1525-0016
eISSN
1525-0024
Invitation Only
No
Cost Range
Open access APC: USD 4,500 excluding taxes; subscription publication: no publication fee charged to authors.
Submission Instructions
Molecular Therapy accepts the following article types. Click on an article type to view submission instructions.
Original Research Article
Cover Letter
A cover letter on institutional letterhead is required. The cover letter must explain the conceptual advance and relevance to readers, provide information relevant to editorial handling, disclose financial conflicts of interest, and describe any related papers and how they relate to the submission.
Abstract
An unstructured abstract is required for Original Research Articles. The abstract must not exceed 200 words. The abstract must be unstructured and presented as a single paragraph. Headings are not permitted in the abstract.
Manuscript
Original Research Articles must be organized as abstract, introduction, results, discussion, materials & methods, data availability statement, acknowledgments, author contributions, declaration of interests statement, 5-10 keywords, references, tables, and a list of figure legends, and the Results and Discussion sections must not be combined. The manuscript must include 5-10 keywords, an author contributions section, a declaration of interests section, and a Declaration of Generative AI and AI-assisted technologies in the writing process before the References when such tools were used.
References
References must include only published or in-press works, be cited as superscript numbers in order of appearance after punctuation, be listed numerically, use PubMed journal title abbreviations, and list the first ten authors followed by et al. when there are more than ten authors.
Figures & Tables
No more than 8 display items consisting of figures and tables are permitted. Tables and the list of figure legends must be included in the manuscript file, and figures may be included after the tables for first-round review but high-resolution figure files must also be uploaded separately. A graphical abstract/eTOC is required.
Review Article
Cover Letter
A cover letter on institutional letterhead is required. The cover letter must explain the conceptual advance and relevance to readers, note information relevant to handling or evaluation, and disclose any financial conflicts of interest.
Abstract
An abstract is required. The abstract must be unstructured and no more than 200 words. The abstract must be unstructured and presented as a single paragraph without headings.
Manuscript
Review Articles must be organized as introduction, text, acknowledgments, author contributions, declaration of interest statement, 5-10 keywords, references, tables, and a list of figure legends. A graphical abstract/eTOC is required, and any use of generative AI in writing must be disclosed in a dedicated declaration section before the References.
References
References must follow a numbered citation style. References must be cited in superscript numerical order of appearance, listed in numerical order, include only published or in-press works, list the first ten authors followed by et al. when there are more than ten, and use PubMed journal abbreviations.
Figures & Tables
No more than 8 display items consisting of figures and tables are permitted. For initial submission, tables must appear at the end of the manuscript and figures may be included after the tables in the manuscript file, while high-resolution figure files must also be uploaded separately. Figures, tables, and equations must be numbered sequentially in Arabic numerals, and a list of figure legends must be included in the manuscript file.
Brief Report
Cover Letter
A cover letter on institutional letterhead is required. Cover letter must explain the conceptual advance and relevance to readers, include information relevant to handling and evaluation, and declare any financial conflicts of interest.
Abstract
An unstructured abstract is required. Abstract must not exceed 200 words. Abstract must be unstructured and presented as a single paragraph without headings.
Manuscript
Manuscript must not exceed 4,000 words excluding disclosures and references. Brief Report must be organized as abstract, introduction, results, discussion, materials and methods, data availability statement, acknowledgments, author contributions, declaration of interest statement, 5-10 keywords, references, tables, and a list of figure legends. Manuscript must include 5-10 keywords, an author contributions section, a declaration of interest statement, and an AI disclosure section before the references if generative AI or AI-assisted writing tools were used.
References
Brief Report must include no more than 30 references. References must be cited as superscript numbers in order of appearance after punctuation, listed in numerical order, and list the first ten authors followed by et al. when there are more than ten authors.
Figures & Tables
Brief Reports may include no more than 3 display items total across figures and tables. Tables and the list of figure legends must be included in the manuscript file, and figures may be included there for initial review but high-resolution figure files must also be uploaded separately. Brief Reports require a graphical abstract/eTOC.
Case Report
Cover Letter
A cover letter on institutional letterhead is required. The cover letter must explain the conceptual advance and relevance to readers, include information relevant to editorial handling, and declare any financial conflicts of interest.
Abstract
An unstructured abstract is required. Abstract must not exceed 200 words. Abstract must be unstructured and presented as a single paragraph without headings.
Manuscript
Manuscript must not exceed 1500 words excluding disclosures and references. Manuscript must be organized as abstract, introduction, patient details and clinical findings, discussion, acknowledgments, author contributions, declaration of interest statement, keywords, references, tables, and a list of figure legends. Manuscript must include 5-10 keywords, an author contributions section, a declaration of interest statement, and a Declaration of Generative AI and AI-assisted technologies in the writing process before the References if such tools were used for writing.
References
References must not exceed 30. References must be cited in superscript numerical order of appearance, listed numerically, include only published or in-press works, list the first ten authors before et al. when there are more than ten authors, and use PubMed journal title abbreviations.
Figures & Tables
Case Reports may include no more than 3 display items in total across figures and tables. For initial submission, tables must appear at the end of the manuscript and figures may be included after the tables in the manuscript file, with high-resolution figure files also uploaded separately. A list of figure legends must appear in the manuscript file after the References, each table must have a title above it, and figure legends must not be placed on the high-resolution figure files.
Letter To The Editor
Cover Letter
A cover letter on institutional letterhead is required. The cover letter must explain the conceptual advance and relevance to readers and provide any information relevant to handling and evaluation of the paper.
Abstract
An abstract is required. The abstract must be 200 words or less. The abstract must be unstructured in a single paragraph.
Manuscript
Letters To The Editor must not exceed 1200 words excluding disclosures and references. No display items are permitted, and any use of generative AI in writing must be disclosed in a dedicated declaration section before the References.
References
No more than 10 references are permitted. References must be cited as superscript numbers in order of appearance and listed in numerical order, with the first ten authors listed before et al. for references with more than ten authors.
Figures & Tables
No display items are permitted. Figures may be included after the tables in the manuscript file for first-round review, and high-resolution figure files must be uploaded separately when submitted.
Recent Publications
From splice defect to therapeutic opportunity: Insights from PRPF31
Frauke Coppieters
10.1016/j.ymthe.2026.08.031
View Publication
Mapping immunocompetent tissues for safer vaccines and gene therapy: A miRNA-based strategy for mRNA-LNP platforms
Mohamed A. Hammad, Hossam M. Ashour
10.1016/j.ymthe.2026.09.016
View Publication
Cryo-thermal therapy reprograms myeloid cells into CCL5+ mature phenotype to increase T-cell infiltration and potentiates anti-PD-1 therapy
Yuankai Hao, Zelu Zhang, Shicheng Wang, Ke Wang, Xiaohui Liu, Ping Liu
10.1016/j.ymthe.2026.09.037
View Publication
Receptor-Ligand Matching for Precision Allogeneic NK Cell Cancer Therapies
Pablo Castro-Córdova, Isidora P. Torres, Felipe Tapia-Rybertt, Joaquín Jerez, Maroun Khoury
10.1016/j.ymthe.2026.09.036
View Publication
Protein trans-splicing: Solving the challenge of gene therapy for large genes
Rachel R. Stine, James J. Dowling
10.1016/j.ymthe.2026.09.017
View Publication
Frequently asked questions
How long does it take to publish?
Median 136 days from submission to acceptance decision for accepted papers.
Reformat to Molecular Therapy using Livewrite PremiumIs a cover letter required?
A cover letter is required on institutional letterhead. It should explain the conceptual advance and relevance to readers and include information relevant to handling and evaluation of the paper, such as related work, time constraints, competition, and any declared conflicts of interest.
Reformat to Molecular Therapy using Livewrite PremiumWhat are the publication costs?
Open access APC is USD 4,500 excluding taxes. Subscription publication has no publication fee charged to authors.
Reformat to Molecular Therapy using Livewrite PremiumResearch Topics
Virus-based gene therapy research
RNA Interference and Gene Delivery
CRISPR and Genetic Engineering
Viral Infectious Diseases and Gene Expression in Insects
CAR-T cell therapy research
Cancer Research and Treatments
Immunotherapy and Immune Responses
Advanced biosensing and bioanalysis techniques
Animal Genetics and Reproduction
Muscle Physiology and Disorders
Herpesvirus Infections and Treatments
Viral gastroenteritis research and epidemiology
Pluripotent Stem Cells Research
Mesenchymal stem cell research
Immune Cell Function and Interaction
Viral Infections and Immunology Research
Cytomegalovirus and herpesvirus research
Tissue Engineering and Regenerative Medicine
Monoclonal and Polyclonal Antibodies Research
MicroRNA in disease regulation
Lysosomal Storage Disorders Research
HIV Research and Treatment
Biomedical Ethics and Regulation
Retinal Development and Disorders
RNA modifications and cancer