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EClinicalMedicine

eClinicalMedicine is an open access journal in The Lancet Discovery Science suite. It publishes basic, translational, clinical, and health systems research and is identified by ISSN 2589-5370.

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Subject Medicine, General & Internal
Impact Factor 10
Quartile Q1
Open Access Type Open
eISSN 2589-5370
Invitation Only No
Cost Range Article processing charge is payable upon acceptance for all full-length peer-reviewed article types; APC information is provided at https://www.thelancet.com/open-access.

Submission Instructions

EClinicalMedicine accepts the following article types. Click on an article type to view submission instructions.

Articles

Cover Letter A cover letter is required for first submissions. Cover letter must explain why the paper should be published in eClinicalMedicine rather than elsewhere.
Abstract Articles must include a semistructured abstract. Abstract should be around 250 words. Abstract must be semistructured in five paragraphs. Abstract paragraphs must be Background, Methods, Findings, Interpretation, and Funding.
Manuscript Articles should be around 3500–5000 words. Primary research Articles must include a Research in context panel. Manuscript must include individual author contributions at the end of the text, a Declaration of interests section, a Role of the funding source section at the end of the Methods, an AI-use disclosure in the acknowledgments if applicable, and a data sharing statement at the end of the manuscript.
References Articles should have 30 references. References must use Vancouver numbering style. References must be cited sequentially in the text as superscript numbers after punctuation marks.
Figures & Tables First submissions should include the manuscript including tables and panels, and figures should also be included in the submission. When reporting Kaplan-Meier survival data, numbers at risk must be included at each timepoint.
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Review

Cover Letter A cover letter is required for first submissions. The cover letter must explain why the paper should be published in eClinicalMedicine rather than elsewhere.
Abstract A 150-word unstructured summary is required. The abstract must not exceed 150 words. The abstract must be unstructured.
Manuscript The manuscript should be around 3500–4000 words. The manuscript should include a brief section entitled “Search strategy and selection criteria.” The manuscript must include a “Search strategy and selection criteria” section describing the sources searched, including databases, MeSH and free-text terms and filters, reference lists from journals or books, and the criteria for including or excluding studies, and any use of generative AI in developing the Review should be described in the methods section with the tool, version, and prompts where applicable.
References The manuscript should have no more than 75 references. References must use Vancouver style. References must be cited sequentially in the text using superscript numbers after punctuation marks, and references in tables, figures, and panels must follow numerical order based on first citation in the text.
Figures & Tables The manuscript may include up to 5 items in total across figures, tables, and panels. The manuscript should be submitted including tables and panels, and figures should also be included with the first submission.
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Correspondence

Cover Letter A cover letter must be included with the first submission. The cover letter must explain why the paper should be published in eClinicalMedicine rather than elsewhere.
Abstract Abstract requirements are not specified.
Manuscript Correspondence responding to previous content must be no longer than 250 words, while correspondence of general interest unlinked to items published in the journal may be up to 400 words. Correspondence should be written in response to previous content published in eClinicalMedicine. An AI disclosure statement at the end of the article is required if generative AI or AI-assisted technologies were used for writing assistance.
References Correspondence responding to previous content should have no more than 5 references. References must use Vancouver numbering style with sequential superscript citations in the text. References must be cited sequentially in the text, and references in tables, figures, and panels must follow numerical order based on first citation in the text.
Figures & Tables Correspondence may include only one table or figure. The manuscript must include tables and panels in the first submission, and figures must also be included in the first submission.
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Recent Publications

Sequential alternation of nal-IRI/5-FU and gemcitabine/nab-paclitaxel versus nal-IRI/5-FU versus gemcitabine/nab-paclitaxel in first-line metastatic pancreatic cancer: results of the randomized phase II PRODIGE 61—FUNGEMAX trial (France)

Julien Taieb, Simon Pernot, Frédéric Thuillier, Alexis Delattre, Erwan Vo-Quang, Caroline Petorin, Vincent Bourgeois, David Tougeron, Franck Audemar, Carole Vitellius, Laurent Mosser, Jérôme Desrame, Frédéric Di Fiore, Yves Rinaldi, Anna Pellat, Marion Bolliet, Fabienne Watelle, Hervé Perrier, Olivier Dubreuil, Come Lepage, Jean-Baptiste Bachet

10.1016/j.eclinm.2026.103998
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Joint modelling of wheeze and lung function from childhood to early adulthood: four population-based birth cohorts

Anhar Ullah, Sara Fontanella, Raquel Granell, Lesley Lowe, Hasan Arshad, Clare S. Murray, Steve Turner, John W. Holloway, Gang Wang, Angela Simpson, Graham Roberts, Erik Melén, Adnan Custovic

10.1016/j.eclinm.2026.103996
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Intimate partner violence, multiple mental health conditions and risk of small vulnerable newborn births: a maternity population-based data linkage study

Lisa Kent, Claire Kerr, Lorna Lawther, Kathryn M. Abel, Holly Hope, Krishnarajah Nirantharakumar, Kelly-Ann Eastwood, Aideen Maguire

10.1016/j.eclinm.2026.103997
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Beta-blocker therapy after myocardial infarction: an umbrella review

Pilar Cataldo-Miranda, Phuong Khanh Cao, Harvey Jia Wei Koh, Danijela Gasevic, Sri Chodapuneedi, Amminadab L. Eliakundu, Lorena Romero, Dion Stub, Sophia Zoungas, David M. Kaye, Stella Talic

10.1016/j.eclinm.2026.103990
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Neoadjuvant sintilimab plus chemotherapy in EGFR-mutant non-small cell lung cancer (NEOTIDE/CTONG2104): phase II trial and correlative genomic analysis in China

Chao Zhang, Ben-Yuan Jiang, Li-Xu Yan, Li-Shan Peng, Jin-Hu Li, Zhi-Yong Chen, Yu-Xuan Sun, Jian Su, Ri-Qiang Liao, Song Dong, Hong-Hong Yan, Chong-Rui Xu, Qing Zhou, Xue-Ning Yang, Zheng Hu, Yi-Long Wu, Wen-Zhao Zhong

10.1016/j.eclinm.2026.103994
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Frequently asked questions

How long does it take to publish?

Papers are aimed to be published online in 2–3 weeks from acceptance. Receipt of submission is acknowledged by email, in-house decisions are communicated quickly, and manuscripts that pass initial assessment are peer reviewed by at least two reviewers and a statistician.

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Is a cover letter required?

A covering letter should be uploaded at the Enter Comments stage of online submission and used to explain why the paper should be published in eClinicalMedicine rather than elsewhere. Detailed responses to reviewers’ comments in a covering letter are also necessary for revised submissions.

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What are the publication costs?

Manuscript submission is free. An article processing charge is payable after acceptance for all full-length peer-reviewed article types.

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Research Topics

COVID-19 Clinical Research Studies SARS-CoV-2 and COVID-19 Research Long-Term Effects of COVID-19 Global Maternal and Child Health HIV/AIDS Research and Interventions COVID-19 and healthcare impacts Vaccine Coverage and Hesitancy COVID-19 and Mental Health Health Systems, Economic Evaluations, Quality of Life COVID-19 epidemiological studies Liver Disease Diagnosis and Treatment Radiomics and Machine Learning in Medical Imaging Global Cancer Incidence and Screening Health disparities and outcomes Diabetes Treatment and Management Neonatal Respiratory Health Research Child Nutrition and Water Access Chronic Obstructive Pulmonary Disease (COPD) Research Suicide and Self-Harm Studies Intensive Care Unit Cognitive Disorders Obesity, Physical Activity, Diet Pneumonia and Respiratory Infections Tuberculosis Research and Epidemiology HIV Research and Treatment Respiratory Support and Mechanisms

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