EJ

European Journal of Clinical Investigation

European Journal of Clinical Investigation is a peer-reviewed general-interest biomedical journal and the official journal of the European Society for Clinical Investigation. It publishes original contributions ranging from basic molecular sciences to applied clinical and translational research, and evidence-based medicine across a broad range of subspecialties.

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Subject Medicine, General & Internal, Medicine, Research & Experimental
Impact Factor 3.6
Quartile Q1
Open Access Type Hybrid
ISSN 0014-2972
eISSN 1365-2362
Invitation Only No
Cost Range Open access APC: $4,300 USD / £2,850 GBP / €3,570 EUR.

Submission Instructions

European Journal of Clinical Investigation accepts the following article types. Click on an article type to view submission instructions.

Original Article

Cover Letter A cover letter is required. The cover letter must include the names, title, email address, and affiliation of at least four independent reviewers with appropriate expertise.
Abstract An abstract is required. The abstract must not exceed 250 words. The abstract must be structured.
Manuscript The manuscript is generally limited to 3500 words, excluding abstract, tables, figures, and references. The manuscript must clearly state an objective or hypothesis, design and methods, essential features of any interventions, main outcome measures, main results, a discussion with literature context and limitations, and conclusions. A maximum of six keywords is allowed, and a graphical abstract is mandatory.
References The manuscript is generally limited to 30 references. AMA References must be numbered consecutively in order of appearance, and entries must list all authors if six or fewer authors are present.
Figures & Tables No more than 7 tables and figures are allowed. Tables and illustrations must be numbered in the order of their citation in the text. A graphical abstract figure must be submitted in TIFF, EPS, or JPEG format within 50 mm x 60 mm at a minimum resolution of 300 dpi, and all tables and illustrations should be original work.
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Clinical Trial

Cover Letter The cover letter must include the names, title, email address, and affiliation of at least four independent reviewers with appropriate expertise.
Abstract An abstract is required. The abstract must not exceed 250 words. The abstract must be structured.
Manuscript The text is limited to 3500 words, excluding abstract, tables, figures, and references. The manuscript must clearly state the objective or hypothesis, essential features of any interventions, main outcome measures, main results, conclusions, design and methods, and a comment section discussing the results in context and study limitations.
References The manuscript is limited to 30 references. AMA References must be numbered consecutively in order of appearance, and reference entries must list all authors if six or fewer authors are present.
Figures & Tables No more than 7 tables and figures are allowed. All clinical trials must include a flow diagram.
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Systemic Review

Cover Letter A cover letter is required. The cover letter must include the names, title, email address, and affiliation of at least four independent reviewers with appropriate expertise.
Abstract An abstract is required. The abstract must not exceed 250 words. The abstract must be structured. The abstract must use the headings Background, Methods, Results, and Conclusions.
Manuscript The text is limited to 4000 words, excluding abstract, tables, figures, and references. A graphical abstract is mandatory, and use of reporting guidelines must be mentioned in both the abstract and the article.
References The manuscript is limited to 100 references. AMA References must be numbered consecutively in order of appearance, and reference entries must list all authors if six or fewer authors are present.
Figures & Tables A maximum of 7 tables or figures is allowed. A flow diagram depicting the search and selection processes should be included, and evidence tables should be included.
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Meta-Analysis

Cover Letter The cover letter must include the names, title, email address, and affiliation of at least four independent reviewers with appropriate expertise.
Abstract required The abstract must not exceed 250 words. structured Background, Methods, Results, and Conclusions.
Manuscript The text is limited to 4000 words excluding abstract, tables, figures, and references. A graphical abstract is mandatory, reporting guidelines must be mentioned in both the abstract and the article, and evidence tables should be included.
References The manuscript is limited to 100 references. AMA References must be numbered consecutively in order of appearance, and list all authors if six or fewer authors are present.
Figures & Tables A maximum of 7 tables or figures is allowed. A flow diagram depicting the search and selection processes should be included.
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Narrative Review

Cover Letter A cover letter is required. The cover letter must include the names, title, email address, and affiliation of at least four independent reviewers with appropriate expertise.
Abstract An abstract is required. The abstract must not exceed 250 words. Structured. Background, Methods, Results, and Conclusions.
Manuscript The text must not exceed 4000 words, excluding abstract, tables, figures, and references. A graphical abstract is mandatory, and a supplemental file indicating whether the manuscript is basic/translational or clinical is required.
References No more than 100 references are allowed. AMA. References must be numbered consecutively in order of appearance, and all authors must be listed when six or fewer authors are present.
Figures & Tables A maximum of 7 tables or figures is allowed. A graphical abstract figure is required, a flow diagram depicting search and selection processes as well as evidence tables should be included, and figures and tables must be numbered in order of citation in the text.
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Research Letter

Cover Letter Required. The cover letter must include the names, title, email address, and affiliation of at least four independent reviewers with appropriate expertise.
Abstract Not allowed.
Manuscript Research Letters are generally limited to 2000 words, excluding tables, figures, and references.
References Research Letters are generally limited to 15 references. AMA. References must be numbered consecutively in order of appearance, and reference entries must list all authors if six or fewer authors are present.
Figures & Tables No more than 5 tables or figures are allowed. All tables and illustrations must be numbered in the order of their citation in the text.
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Recent Publications

Mitochondrial DNA Copy Number and Mitochondrial Homeostasis Genes in Acute and Stable Coronary Artery Disease

Paola Canale, Jonica Campolo, Marina Parolini, Cinzia Dellanoce, Emanuela Piccaluga, Irene Bossi, Matteo Maurina, Jacopo A. Oreglia, Rosa Sicari, Maria Grazia Andreassi

10.1111/eci.70269
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Issue Information

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10.1111/eci.70231
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Fertility Treatment and Risk of Melanoma: A Certainty‐Rated Systematic Review and Meta‐Analysis of 3,733,499 Women

Dimitrios Stylianakis, Cinzia Solinas, Fausto Petrelli, Gianluca Nazzaro, Emanuela Passoni, Serafina Martella, Ioannis Stylianakis, Laura Atzori, Mario Scartozzi, Matteo Lambertini, Ornella Garrone, Nerina Denaro

10.1111/eci.70266
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Lower, Earlier, Longer and Personalized: Rethinking Lipid‐Lowering Therapy for Cardiovascular Prevention

Chiara Dalla Valle, Marco Zuin, Claudio Bilato

10.1111/eci.70267
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Proprotein Convertase Subtilisin/Kexin Type 9: From Biology to Therapeutic Targeting in Cardiovascular Disease

Riccardo Rizzo, Bianca S. Daraban, Irina F. Tudorache, Davide Barbarossa, Francesca Protopapa, Amirbahman Zeynali, Francesco M. Esposito, Alberico L. Catapano

10.1111/eci.70263
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Frequently asked questions

How long does it take to publish?

Submission to first decision: 2 days median. Submission to acceptance: 70 days median. Acceptance to publication: 17 days median.

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Is a cover letter required?

A cover letter is required. It must include complete contact information for the corresponding author, whether related papers or preprints exist, conflict of interest information, and a statement of contributions/responsibility. At least four independent reviewers must also be suggested.

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What are the publication costs?

If the article is not published open access, a signed Copyright Transfer Agreement or Exclusive License Agreement is required before publication processing. Open access articles are published under a Creative Commons license.

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Research Topics

Diabetes, Cardiovascular Risks, and Lipoproteins Lipoproteins and Cardiovascular Health Adipokines, Inflammation, and Metabolic Diseases Liver Disease Diagnosis and Treatment Cardiovascular Function and Risk Factors Nitric Oxide and Endothelin Effects Diet and metabolism studies Drug Transport and Resistance Mechanisms Adipose Tissue and Metabolism Heart Failure Treatment and Management Muscle metabolism and nutrition Liver Disease and Transplantation Atrial Fibrillation Management and Outcomes Diabetes Treatment and Management Cardiovascular Health and Disease Prevention Parathyroid Disorders and Treatments Pancreatic function and diabetes Atherosclerosis and Cardiovascular Diseases Antiplatelet Therapy and Cardiovascular Diseases Cholesterol and Lipid Metabolism Blood properties and coagulation Fatty Acid Research and Health Folate and B Vitamins Research Neutrophil, Myeloperoxidase and Oxidative Mechanisms Hormonal Regulation and Hypertension

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