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Fluids and Barriers of the CNS

Fluids and Barriers of the CNS is a community-focused journal dedicated to research on the molecular, physiological, pathological and pharmacological aspects of brain fluids and barrier systems and their roles in neurological disorders. It is affiliated with the International Brain Barriers Society and the Hydrocephalus Society and emphasizes high quality, constructive peer review.

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Subject Neurosciences
Impact Factor 6.2
Quartile Q1
Open Access Type Open
ISSN 2045-8118
eISSN 2045-8118
Invitation Only No
Cost Range APC: £2690.00 GBP / $3490.00 USD / €2990.00 EUR, plus VAT or local taxes where applicable.

Submission Instructions

Fluids and Barriers of the CNS accepts the following article types. Click on an article type to view submission instructions.

Research

Cover Letter A cover letter is required. Cover letter must explain why the manuscript should be published in Fluids and Barriers of the CNS, address any issues relating to journal policies, declare any potential competing interests, confirm all authors approved the submission, and confirm the content has not been published or submitted elsewhere.
Abstract An abstract is required. Abstract must not exceed 350 words. Abstract must be structured. Abstract must include the headings Background, Methods, Results, Conclusions, and Trial registration.
Manuscript Manuscript must include a title page, Background, Methods, Results, Discussion, Conclusions, a Declarations section with all required subheadings, and three to ten keywords. Manuscript must include three to ten keywords, document any use of a Large Language Model in the Methods section or suitable alternative part, and include all Declarations subheadings with 'Not applicable' where a subsection is not relevant.
References References must use Vancouver style. Only published or in-press articles, clinical trial registration records, abstracts, and publicly available e-prints or preprints may be cited, unpublished abstracts, unpublished data, and personal communications must be excluded from the reference list, journal abbreviations must follow Index Medicus/MEDLINE, and all URLs must appear as full references in the reference list.
Figures & Tables Figures must be uploaded as separate files, while tables shorter than one page may be placed within the manuscript and longer tables may be placed at the end of the text file. Multi-panel figures must be submitted as single composite files, figure titles and legends must appear in the manuscript rather than the graphic files, and tables must not be embedded as figures or spreadsheet files.
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Review

Cover Letter A cover letter is required. Cover letter must explain why the manuscript should be published in Fluids and Barriers of the CNS, address any issues relating to journal policies, declare any potential competing interests, confirm all authors approved the submission, and confirm the content has not been published or submitted elsewhere.
Abstract An abstract is required. Abstract must not exceed 350 words. Abstract must be structured. Abstract must include Background, Main body of the abstract, and short Conclusion.
Manuscript Manuscript must include a title page, Background, Main text, Conclusions, and a Declarations section with the subheadings Ethics approval and consent to participate, Consent for publication, Availability of data and materials, Competing interests, Funding, Authors' contributions, and Acknowledgements. Manuscript must include three to ten keywords, a list of abbreviations if abbreviations are used, and 'Not applicable' under any Declarations subsection that is not relevant.
References References must use Vancouver style. Only articles, clinical trial registration records, and abstracts that are published, in press, or publicly available as e-prints or preprints may be cited, unpublished abstracts, unpublished data, and personal communications must be excluded from the reference list, journal abbreviations must follow Index Medicus/MEDLINE, and all web links and URLs must appear as full references with title, URL, and access date.
Figures & Tables Tables shorter than one page may be placed within the manuscript, tables longer than one page may be placed at the end of the text file, and figure titles and legends must be provided in the main manuscript rather than in the graphic files. Figures and tables must be numbered in the order first cited in the text, multi-panel figures must be submitted as a single composite file, tables must not be embedded as figures or spreadsheet files, and table titles and figure titles must not exceed 15 words while table legends and figure legends must not exceed 300 words.
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Brief Report

Cover Letter A cover letter is required. Cover letter must explain why the manuscript should be published in Fluids and Barriers of the CNS, address any issues relating to journal policies, declare any potential competing interests, confirm all authors approved the submission, and confirm the manuscript has not been published or submitted elsewhere.
Abstract An abstract is required. Abstract must not exceed 250 words. Abstract structure is not specified. Abstract should briefly summarize the aim, findings, or purpose of the article and should not cite references while minimizing abbreviations.
Manuscript Main text should contain the body of the article and may be divided into subsections with short, informative headings. Manuscript must include an Availability of data and materials statement, three to ten keywords, a list of abbreviations if abbreviations are used, documentation of any Large Language Model use in the Methods section or suitable alternative part, and Declarations subsections with 'Not applicable' where relevant.
References References must follow Vancouver style. Only published or in-press articles, clinical trial registration records, abstracts, and public e-prints or preprints may be cited, unpublished abstracts/data and personal communications must not appear in the reference list, journal abbreviations must follow Index Medicus/MEDLINE, and web links must be numbered references listed in full with site title, URL, and access date.
Figures & Tables Tables less than one page may be placed within the manuscript, larger tables may be placed at the end of the text file, and figure titles and legends must appear in the main manuscript rather than in the graphic files. Figures and tables must be numbered in the order first cited, multi-panel figures must be submitted as single composite files, tables must be created with the word processor's table function rather than embedded as figures or spreadsheets, and footnotes to tables should use superscript lower-case letters or asterisks for significance values.
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Correspondence

Cover Letter A cover letter is required. Cover letter must explain why the manuscript should be published in Fluids and Barriers of the CNS, address any issues relating to journal policies, declare any potential competing interests, confirm all authors approved submission, and confirm the content has not been published or submitted elsewhere.
Abstract An abstract is required. Abstract must not exceed 250 words. Abstract is unstructured. Abstract must briefly summarize the aim, findings, or purpose of the article and should minimize abbreviations and contain no references.
Manuscript Manuscript must include the section headings Title page, Abstract, Keywords, Main text, List of abbreviations, References, and Declarations. Manuscript must include three to ten keywords, a list of abbreviations if abbreviations are used, a Declarations section including all subheadings, and any LLM use must be documented in the Methods section or another suitable part of the manuscript if no Methods section is available.
References References must follow Vancouver style. Only articles, clinical trial registration records, and abstracts that are published, in press, or publicly available as e-prints or preprints may be cited, unpublished abstracts, unpublished data, and personal communications must not appear in the reference list, journal abbreviations must follow Index Medicus/MEDLINE, and web links must be numbered and listed in full with title, URL, and access date.
Figures & Tables Tables less than one page may be placed within the manuscript, larger tables may be placed at the end of the text file, and figure titles and legends must be provided in the main manuscript rather than in the graphic file. Figures and tables must be numbered in the order first mentioned in the text, multi-panel figures must be submitted as single composite files, and tables must not be embedded as figures or spreadsheet files.
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Recent Publications

Blood-brain barrier dysfunction and altered choroid plexus contrast kinetics in Parkinson’s disease

Sapir Fajerzstein, Gadi Maayan Eshed, Sheida Mirloo, Aviad Rabinowich, Avner Thaler, Anat Mirelman, Tamara Shiner, Nir Giladi, Roy N. Alcalay, Rotem Iris Orad, Moran Artzi, Noa Bregman, Lyna Kamintsky, Nurit Omer, Adi Brenner-Ullman, Dafna Ben Bashat, Dan Z. Milikovsky

10.1186/s12987-026-00890-7
View Publication

Mitochondrial transfer and transplantation as emerging neurotherapeutic strategies for central nervous system disorders

Jingyi Li, Mingfu Zhang, Shiping Li, Yi Qu

10.1186/s12987-026-00887-2
View Publication

Elevated apparent diffusion coefficient of extra-axial space in patients with traumatic brain injury

Nicole L. Peterkin, Sophia Z. Cheng, Marie L. Luby, L. Christine Turtzo, Lawrence L. Latour

10.1186/s12987-026-00883-6
View Publication

Transport of FGF21 across the blood-brain barrier: mechanisms and receptor activation

Sabrine Linhares, Manon Leclerc, Josue Valentin-Escalera, Dominique Seguin, Émilie Courteau, Vincent Émond, Cyntia Tremblay, Frédéric Calon

10.1186/s12987-026-00885-4
View Publication

Intrathecal mesenchymal stem cell therapy in progressive multiple sclerosis: integrated blood and CSF profiling in the SMART-MS randomized trial

Dimitrios Kleftogiannis, Sonia Gavasso, Live Egeland Eidem, Jonas Bull Haugsøen, Trygve Holmøy, Linn Steffensen, Kristin Wesnes, Markus Rojewski, Harald Barsnes, Niyaz Al-Sharabi, Samih Mohamed-Ahmed, Marie Ytterdal, Casper Eugen Sandvik, Øivind Torkildsen, Hubert Schrezenmeier, Kamal Mustafa, Frode Steingrimsen Berven, Lars Bø, Torbjørn Kråkenes, Christopher Elnan Kvistad

10.1186/s12987-026-00886-3
View Publication

Frequently asked questions

How long does it take to publish?

Submission to first decision (median): 6 days.

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Is a cover letter required?

A cover letter is required and should explain why the manuscript should be published in Fluids and Barriers of the CNS, note any issues relating to journal policies, declare potential competing interests, confirm all authors approved the submission, confirm the work has not been published or submitted elsewhere, and name the special issue if applicable. Authors may also suggest preferred and non-preferred peer reviewers in the cover letter.

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What are the publication costs?

Article processing charge: £2690.00 GBP / $3490.00 USD / €2990.00 EUR for each accepted article, plus VAT or local taxes where applicable. Waivers and discounts may be available.

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Research Topics

Cerebrospinal fluid and hydrocephalus Barrier Structure and Function Studies Traumatic Brain Injury and Neurovascular Disturbances Fetal and Pediatric Neurological Disorders Neurosurgical Procedures and Complications Intracerebral and Subarachnoid Hemorrhage Research Spinal Dysraphism and Malformations Drug Transport and Resistance Mechanisms Head and Neck Surgical Oncology Alzheimer's disease research and treatments Advanced MRI Techniques and Applications Neurogenesis and neuroplasticity mechanisms Neonatal and fetal brain pathology Neuroinflammation and Neurodegeneration Mechanisms Advanced Neuroimaging Techniques and Applications Cerebral Venous Sinus Thrombosis Neuroscience and Neuropharmacology Research Glioma Diagnosis and Treatment Multiple Sclerosis Research Studies Neurological Disease Mechanisms and Treatments Angiogenesis and VEGF in Cancer Intracranial Aneurysms: Treatment and Complications Neuroscience of respiration and sleep Caveolin-1 and cellular processes S100 Proteins and Annexins

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