Overview
Submission Instructions
Recent Publications
Frequently Asked Questions
Research Topics
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Frontiers in Genetics is an open-access genetics and heredity journal that highlights genetic and genomic inquiry across all domains of life, from humans to plants and other model organisms.
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Subject
Genetics & Heredity
Impact Factor
2.8
Quartile
Q2
Open Access Type
Open
eISSN
1664-8021
Invitation Only
No
Cost Range
APCs: CHF 3,150 for A-Type Articles and CHF 2,500 for B-Type Articles.
Submission Instructions
Frontiers in Genetics accepts the following article types. Click on an article type to view submission instructions.
Original Research
Cover Letter
Cover Letter requirements are not specified.
Abstract
An abstract is required. Abstract must be structured in a single paragraph.
Manuscript
Manuscript must not exceed 12,000 words. Manuscript should follow the format Abstract, Introduction, Materials and Methods, Results, and Discussion, with a succinct Introduction containing no subheadings. The first page must indicate the manuscript word count and the number of figures and tables, include 5 to 8 keywords, and acknowledge any use of generative AI in the acknowledgements and methods section if applicable.
References
References must include all and only works cited in the text, list the first six authors followed by et al. with authors’ given names abbreviated to initials, and include the DOI when available.
Figures & Tables
Figures must be submitted individually and figure captions placed at the end of the manuscript, while tables must be directly inserted at the end of the manuscript in editable form. All figures must include alt text and each figure and table must be cited in the text in numerical order.
Systematic Review
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must be structured in a single paragraph.
Manuscript
Manuscript must not exceed 12,000 words. Manuscript should be organized as Abstract, Introduction, Methods, Results, and Discussion, with Methods covering study design, participants, interventions, comparators, systematic review protocol, search strategy, data sources, study selections and data extraction, and data analysis, Results covering a flow diagram of retrieved studies, study selection and characteristics, synthesized findings, and assessment of risk of bias, and Discussion covering summary of main findings, limitations, and conclusions. Manuscript must clearly define the research question using PICOS, include funding information, and acknowledge any generative AI use in the acknowledgements and methods sections with the technology name, version, model, and source if applicable.
References
References should list the first six authors followed by et al. and DOI when available, and unpublished material including unpublished or original data, submitted manuscripts, and personal communications must not be included.
Figures & Tables
Figures must be submitted individually with captions placed at the end of the manuscript, while tables must be inserted directly into the manuscript at the end. All figures or images must include alt text.
Review
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract should be structured in a single paragraph.
Manuscript
Manuscript must not exceed 12,000 words. Manuscript should follow the format Abstract, Introduction, subject-relevant subsections, and Discussion. The first page must indicate the manuscript word count and number of figures and tables, include 5 to 8 keywords, and any use of generative AI must be acknowledged in the acknowledgements section and in the methods section if applicable with the name, version, model, and source.
References
References must include only published or accepted works, list the first six authors followed by et al. with authors’ given names as initials and DOI when available, and unpublished material such as personal communications must not be included.
Figures & Tables
Figures must be submitted individually with captions placed at the end of the manuscript, and tables must be inserted directly into the manuscript at the end in editable format. Each figure and table must be cited in the text in numerical order, and all figures or images must include alt text.
Policy And Practice Reviews
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract should be structured as a single paragraph.
Manuscript
Manuscript must not exceed 12,000 words. Manuscript should be organized as Abstract, Introduction, sections on assessment of policy/guidelines options and implications, Actionable Recommendations, and Discussion. Manuscript must include at least five and no more than eight keywords, indicate the word count and number of figures and tables on the first page, and disclose any generative AI use in the acknowledgements section and in the methods section if applicable.
References
References must include the first six authors followed by et al., abbreviate given names to initials, provide the DOI when available, and ensure all in-text, figure, and table citations appear in the reference list and vice versa.
Figures & Tables
Figures must be submitted individually with captions placed at the end of the manuscript, and tables must be inserted directly into the manuscript. All figures or images must include alt text, and each figure and table must be cited in the text in numerical order.
Clinical Trial
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract should be structured as a single paragraph. Abstract must include the clinical trial registry number.
Manuscript
Manuscript must not exceed 12,000 words. Manuscript should be organized as Abstract, Introduction, Materials and Methods, Results, and Discussion. Use of content produced by or edited with generative AI must be acknowledged in the acknowledgements section and in the Methods section if applicable, including the name, version, model, and source of the technology.
References
References should list the first six authors followed by et al., abbreviate given names to initials, and include the DOI when available.
Figures & Tables
Figures must be submitted individually and figure captions placed at the end of the manuscript, while tables must be inserted directly into the manuscript at the end in editable format. All figures or images must include alt text.
Registered Report
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract should be structured in a single paragraph.
Manuscript
Stage 1 manuscripts must not exceed 3,000 words, and Stage 2 complete manuscripts must not exceed 12,000 words. Stage 1 should be organized as Abstract, Introduction, Methods, and preliminary results from pilot experiments if applicable, while Stage 2 should contain the peer-reviewed Stage 1 sections plus Results and Discussion. Stage 2 results containing unregistered analyses must be presented separately under 'Exploratory Analysis,' and any generative AI use must be acknowledged in the acknowledgements and methods sections if applicable.
References
References should list the first six authors followed by et al., abbreviate given names to initials, include DOIs when available, and ensure every in-text, figure, or table citation appears in the reference list and vice versa.
Figures & Tables
Stage 1 may include no more than 2 figures/tables, and Stage 2 may include no more than 15 figures/tables. Figures must be submitted individually with captions at the end of the manuscript, and tables must be inserted directly into the manuscript. Figures must be cited in numerical order and include alt text, and tables must also be cited in numerical order.
Mini Review
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract should be structured as a single paragraph.
Manuscript
Manuscript must not exceed 3,000 words. Manuscript should be organized as Abstract, Introduction, subject-relevant subsections, and Discussion. The first page must state the manuscript word count and number of figures and tables, and any use of generative AI content must be disclosed in the acknowledgements and in the methods section if applicable with the name, version, model, and source.
References
References must list the first six authors followed by et al. and include the DOI when available, and Mini Reviews must not cite unpublished material, submitted manuscripts, or personal communications.
Figures & Tables
Mini Review articles may include no more than 2 figures and/or tables. Figures must be submitted individually with captions placed at the end of the manuscript, and tables must be inserted directly into the manuscript at the end. All figures must include alt text and be cited in numerical order in the text, and tables must also be cited in numerical order in the text.
Case Report
Cover Letter
Cover Letter requirements are not specified.
Abstract
An abstract is required for Case Reports. The abstract should be structured in a single paragraph.
Manuscript
The manuscript must not exceed 3,000 words. The manuscript should be organized as Abstract, Introduction, Case description, a figure or table timeline, Diagnostic assessment, Therapeutic intervention, Follow-up and outcomes, Discussion, and Patient perspective. The manuscript must include 5 to 8 keywords and any use of generative AI content must be disclosed in the acknowledgements section and in the methods section if applicable, including the tool name, version, model, and source.
References
References should list the first six authors followed by et al., abbreviate given names to initials, include the DOI when available, and ensure every in-text, figure, and table citation appears in the reference list and vice versa.
Figures & Tables
Case Reports may include no more than 4 display items in total. Figures must be submitted individually with captions placed at the end of the manuscript, while tables must be directly inserted into the manuscript at the end. The manuscript should include a figure or table presenting a timeline with relevant data from the episode of care, and all figures and tables must be cited in the text in numerical order.
Community Case Study
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract should be structured in a single paragraph. Abstract is required as part of the article format, but no specific abstract headings are stated.
Manuscript
Manuscript must not exceed 5,000 words. Manuscript should be organized as Abstract; Introduction describing the nature of the problem being addressed and rationale for the proposed innovation; Context setting and population in which the innovation occurs; Detail to understand key programmatic elements; Discussion sharing practical implications and lessons learned for future applications; and Acknowledgment of any conceptual or methodological constraints. The manuscript must include at least five and no more than eight keywords, indicate the number of words and figures/tables on the first page, and acknowledge any generative AI use in the acknowledgements section and in the methods section if applicable.
References
References should list the first six authors followed by et al., abbreviate given names to initials, include DOIs when available, and ensure every in-text, figure, or table citation appears in the reference list and vice versa.
Figures & Tables
The article may contain no more than 5 figures and/or tables in total. Figures must be submitted individually with captions placed at the end of the manuscript, while tables must be inserted directly into the manuscript. Figures and tables must be cited in the text in numerical order, and all figures or images must include alt text.
Data Report
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract should be structured in a single paragraph, for example according to the IMRAD format.
Manuscript
Manuscript must not exceed 3,000 words. Manuscript should be organized as Introduction; Methods used to collect the data, including the data collection period, filters applied, and guidance on interpreting and reusing the dataset; some analysis of the data; and relevant subsections, and it must not include Results or Discussion sections. Manuscript must include the dataset name, the database or repository where the dataset was submitted, the confidential peer review link to the dataset to be replaced with the public link before publication, at least five and no more than eight keywords, and an acknowledgement statement giving the name, version, model, and source of any generative AI technology used.
References
References should list the first six authors followed by et al., abbreviate given names to initials, include the DOI when available, and ensure every in-text, figure, and table citation appears in the reference list and vice versa.
Figures & Tables
No more than 2 figures and/or tables are allowed. Figures must be submitted individually with captions placed at the end of the manuscript, and tables must be directly inserted into the manuscript at the end. Each figure and table must be cited in the text in numerical order, and all figures or images must include alt text.
Brief Research Report
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract should be structured as part of the required format and presented as a single paragraph.
Manuscript
Manuscript must not exceed 4,000 words. Manuscript should follow the format Abstract, Introduction, Method, Results, Discussion. The manuscript must include an acknowledgment in the acknowledgements section and in the methods section if applicable that discloses any use of generative AI, including the name, version, model, and source.
References
References should list the first six authors followed by et al., abbreviate given names to initials, include the DOI when available, and ensure every in-text, figure, or table citation appears in the reference list and vice versa.
Figures & Tables
Brief Research Report articles may contain no more than 4 figures and/or tables in total. Figures must be submitted individually with captions placed at the end of the manuscript, while tables must be inserted directly into the manuscript. All figures or images must include alt text.
Technology And Code
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must be structured as part of the required Abstract, Introduction, Method, Results, Discussion format.
Manuscript
Manuscript must not exceed 12,000 words. Manuscript must follow the format Abstract, Introduction, Method, Results, Discussion. Manuscript must include a project link, operating system, programming language, any restrictions for non-academic use, and acknowledgment details for any generative AI content in the acknowledgements section and methods section if applicable.
References
References should list the first six authors followed by et al., abbreviate given names to initials, include the DOI when available, and ensure every in-text, figure, or table citation appears in the reference list and vice versa.
Figures & Tables
Figures must be submitted individually and tables must be inserted directly into the manuscript. Figure captions must be placed at the end of the manuscript, table captions must appear immediately before each table, and alt text must be included with all figures or images.
Fair² Data
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must be structured in a single paragraph, for example according to the IMRAD format.
Manuscript
Manuscript must not exceed 12,000 words. Manuscript must include 5 to 8 keywords, indicate the total word count and number of figures and tables on the first page, and acknowledge any generative AI use in the acknowledgements and methods section if applicable.
References
References must include all and only works cited in the text, list the first six authors followed by et al. with authors’ given names abbreviated to initials, and include the DOI when available.
Figures & Tables
Manuscript may include up to 15 figures or tables. Figures must be submitted individually with captions placed at the end of the manuscript, while tables must be directly inserted into the manuscript. Each figure and table must be cited in the text in numerical order, and all figures or images must include alt text.
Recent Publications
CircRNAs in hepatic lipid metabolism: regulatory mechanisms and clinical implications
Yu Zeng, Meng Gao
10.3389/fgene.2026.1831613
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Age-associated clinical characteristics and ATP7B mutation landscape in pediatric Wilson’s disease: a study from southwest China
Tingting Wu, Yuanzhen Zhang, Xiaorong Peng, Yunnan Chang, Tao Qin, Jing Zhu, Qiqin Tang, Jiao Tian, Ruiqiu Zhao, Hongmei Xu
10.3389/fgene.2026.1839993
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scCCVGBen for benchmarking of single-cell representation learning anchored on a centroid-coupled variational graph attention autoencoder across scRNA-seq and scATAC-seq
Zeyu Fu, Jiawei Fu, Chunlin Chen, Keyang Zhang, Junping Wang, Tianfei Ran, Song Wang
10.3389/fgene.2026.1822168
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Codon usage bias and molecular evolution of Dnajc15 across avian lineages
Zeshuo Zhou, Jianke Yang, Duminda S. B. Dissanayake, Lisa Schwanz, Arthur Georges, Lei Xiong
10.3389/fgene.2026.1841532
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Comparative genomics across Linum illuminates the evolutionary basis of flax domestication, genome diversification, and seed oil biosynthesis
Liuxi Yi, Rula Sa, Yingnan Mu, Jinhao Zhang, Ruichao He, Yadi Song, Yu Zhou, Yongsheng Chen
10.3389/fgene.2026.1835945
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Frequently asked questions
How long does it take to publish?
The editorial decision is taken upon finalization of the review, and publication occurs after article production.
Reformat to Frontiers in Genetics using Livewrite PremiumIs a cover letter required?
A traditional cover letter is not accepted. Authors must prepare a 200-word statement describing the manuscript’s contribution to the field.
Reformat to Frontiers in Genetics using Livewrite PremiumWhat are the publication costs?
Article processing charges are CHF 3,150 for A-Type Articles and CHF 2,500 for B-Type Articles. APCs apply to articles that pass peer review and are accepted for publication.
Reformat to Frontiers in Genetics using Livewrite PremiumResearch Topics
Cancer-related molecular mechanisms research
RNA modifications and cancer
Ferroptosis and cancer prognosis
MicroRNA in disease regulation
Genetic and phenotypic traits in livestock
Epigenetics and DNA Methylation
Genetic Mapping and Diversity in Plants and Animals
Bioinformatics and Genomic Networks
Genomics and Phylogenetic Studies
RNA Research and Splicing
Genetic Associations and Epidemiology
Circular RNAs in diseases
Genomics and Rare Diseases
Gene expression and cancer classification
RNA and protein synthesis mechanisms
Genomic variations and chromosomal abnormalities
Genetic diversity and population structure
Cancer Genomics and Diagnostics
CRISPR and Genetic Engineering
Genetics and Neurodevelopmental Disorders
Chromosomal and Genetic Variations
Genomics and Chromatin Dynamics
Cancer Immunotherapy and Biomarkers
Cancer-related gene regulation
Machine Learning in Bioinformatics