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Immunity

Immunity publishes advances in immunology research, including studies that provide fundamental new immunological insights at the molecular, cellular, or whole organism level relevant to areas such as cancer, infectious disease, the nervous system, autoimmunity, allergy, mucosal immunity, and homeostasis.

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Subject Immunology
Impact Factor 26.3
Quartile Q1
Open Access Type Hybrid
ISSN 1074-7613
eISSN 1097-4180
Invitation Only No
Cost Range Article publishing charge: $10,400 for open access.

Submission Instructions

Immunity accepts the following article types. Click on an article type to view submission instructions.

Research

Cover Letter A cover letter is required. Cover letter must explain the prior background, the conceptual advance, the significance and potential impact of the work, and state if the paper is part of a consortium.
Abstract A summary is required. Summary must be a single paragraph of no more than 150 words. Summary must be unstructured as a single paragraph. Summary should include the background or purpose, principal results, approaches or model systems, major conclusions, and broader significance without reference citations.
Manuscript Research articles must be under 7,000 words including spaces and main figure legends but excluding STAR Methods text, supplemental item legends, and the references section. Manuscript should include Title, Author list, Author affiliations and footnotes, Contact information, Summary, Keywords, Introduction, Results, Limitations of the study, Discussion, Resource availability, Acknowledgments, Author contributions, Declaration of interests, Declaration of generative AI and AI-assisted technologies, Supplemental information titles and legends, Figure and or scheme titles and legends, Tables, STAR Methods, Resource identification initiative, and References in that order. Up to 10 keywords may follow the summary, the manuscript must include a Resource Availability section with the subsections Lead Contact, Materials Availability, and Data and Code Availability, a dedicated Author Contributions section immediately after Acknowledgments, a Declaration of Interests section, and a generative AI declaration section only if AI-assisted writing was used.
References References must use numbered superscript citations. References must be numbered sequentially by first citation, include only one article per reference entry, and use "et al." only after 10 author names.
Figures & Tables Research articles may contain no more than seven main figures and or tables unless discussed with the editors. Main-text figures or schemes must be uploaded as separate files with titles and legends in a single Figures section of the manuscript, while main-text tables should appear at the end of the manuscript after the figure or scheme legends. Figures and tables must be cited in numerical order in the main text, figures must include descriptive titles and legends, and tables must be editable, titled, and not divided into panels.
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Report

Cover Letter A cover letter is required. Cover letter must explain the background, conceptual advance, and significance or potential impact of the work, and must state if the paper is part of a consortium.
Abstract A summary or abstract is required. Summary must be a single paragraph of 150 words or fewer. Summary must be unstructured as a single paragraph.
Manuscript Reports must not exceed 4,000 words including title, author names and affiliations, summary, spaces, and figure legends but excluding STAR Methods text, supplemental item legends, and the references section. Main document must include, in order, title, author list and affiliations, Lead Contact footnote, corresponding author email address(es), Summary, Introduction, Results, Discussion, Resource Availability, Acknowledgments, Author Contributions, Declaration of Interests, main figure titles and legends, main tables and legends, STAR Methods text, supplemental video and Excel table titles and legends, and References. Manuscript must include 3 to 4 Highlights of no more than 85 characters each plus an eTOC blurb of no more than 50 words in a separate Word document, and a Declaration of Generative AI and AI-assisted technologies in the writing process section only if such tools were used.
References References must use numbered superscript citations in consecutive order. References must be numbered by first citation, list only one article per reference, use 'et al.' only after 10 author names, include only published, in-press, or identified preprint material in the reference list, and article references must include author list, year, title, journal abbreviation, volume, page range, and DOI.
Figures & Tables Reports may contain up to 4 display items and no more than 4 supplemental figures, with tables and or movies allowed for a total of up to 8 supplemental items. Main-text figures must be uploaded as separate files with titles and legends in a single figures section of the manuscript, while main-text tables must appear at the end of the manuscript after the figure legends. Figures must be cited in numerical order and include a brief descriptive title and legend, and tables must be editable, numbered consecutively, include a descriptive title, and not be divided into panels.
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Review

Cover Letter Cover letter is required. Cover letter must explain the prior background, the conceptual advance, the significance and potential impact of the work, and state if the paper is part of a consortium.
Abstract Abstract is required. Abstract must not exceed 150 words. Abstract should be unstructured as a single paragraph.
Manuscript Review manuscript must be 5,000 to 7,000 words in length. Main document should include title, author list and affiliations, Lead Contact footnote, corresponding author email address(es), Summary, Introduction, Results, Discussion, Resource Availability if applicable, Acknowledgments, Author Contributions, Declaration of Interests, main figure titles and legends, main tables and legends, STAR Methods text, supplemental item titles and legends, and References. Manuscript must include Highlights of 3 to 4 bullet points of no more than 85 characters each, an eTOC blurb of no more than 50 words, an Author Contributions section using author initials, a Declaration of Interests statement identical to the submitted form, and a generative AI disclosure section only if AI-assisted writing was used.
References Reviews may include up to 150 references. References must use numbered superscript citation style. References must be numbered sequentially by first citation, list only one article per entry, and use "et al." only after 10 author names.
Figures & Tables Reviews may include 3 or 4 display items in total, consisting of figures and/or tables. Main-text figures must be uploaded as separate files with titles and legends in a single figures section of the manuscript, while main-text tables should appear at the end of the manuscript after the figure legends. Figures and tables must be cited in numerical order in the main text, tables must be editable and include a title, and tables must not be divided into panels.
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Letter

Cover Letter A cover letter is required. Cover letter must explain the background, the conceptual advance, and the significance and potential impact of the work, and it must state if the paper is part of a consortium.
Abstract A summary or abstract is required. Summary must be a single paragraph of 150 words or fewer. Summary must be unstructured as a single paragraph.
Manuscript Letters must be no more than 1,500 words in length. The main document must include sections in the order title, author list and affiliations, Lead Contact footnote, corresponding author email address(es), Summary, Introduction, Results, Discussion, Resource Availability, Acknowledgments, Author Contributions, Declaration of Interests, main figure titles and legends, main tables and legends, STAR Methods text, supplemental video and Excel table titles and legends, and References. The manuscript must include a Resource Availability section with the subheadings Lead Contact, Materials Availability, and Data and Code Availability, a Declaration of Interests section matching the declaration form, an Author Contributions section using initials, a separate Highlights and eTOC Blurb document, and a Declaration of Generative AI and AI-assisted technologies in the writing process section only if AI-assisted writing was used.
References Letters may have up to 10 references. References must use numbered superscript citations in consecutive order. References must be numbered sequentially by first citation, each entry must contain only one article, and "et al." may be used only after 10 author names.
Figures & Tables Letters may include 1 supplemental figure. Main-text figures or schemes must be uploaded as separate files, figure and scheme titles and legends must appear in a single figures section in the manuscript, and main-text tables must appear at the end of the manuscript after the figure or scheme legends. Figures must be cited in numerical order and tables must be cited in the main text, and tables must be editable black-and-white tables without panels.
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Brief Report

Cover Letter A cover letter is required. Cover letter must explain the prior background, the conceptual advance, and the significance and potential impact of the work, and must state if the paper is part of a consortium.
Abstract An abstract is required. Summary must be a single paragraph of 150 words or fewer. Abstract must be unstructured as a single-paragraph summary.
Manuscript Brief Reports must contain up to 2,500 words of main text excluding references. Brief Reports must use contiguous text without section breaks, with experimental procedures presented in the supplemental information. Manuscript must include an Author Contributions section using author initials, a Declaration of Interests section matching the form text exactly, and a declaration of generative AI use if applicable.
References References must be numbered sequentially by first citation and cited in the text as superscript numbers, with 'et al.' used only after 10 author names.
Figures & Tables Brief Reports may include up to 2 display items in the main article and up to 4 supplemental items total as tables and/or movies. Main-text figures must be uploaded as separate files, tables must appear at the end of the manuscript, and experimental procedures must be included in the supplemental information. Figure titles and legends must be provided in a single figures section within the manuscript, and tables must be editable Word tables with a descriptive title.
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Recent Publications

Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling

Nicholas A. Spidale, Katelyn Sylvia, Kavitha Narayan, Bing Miu, Michela Frascoli, Heather J. Melichar, Wu Zhihao, Jan Kisielow, Amy Palin, Thomas Serwold, Paul Love, Michihiro Kobayashi, Momoko Yoshimoto, Nitya Jain, Joonsoo Kang

10.1016/j.immuni.2026.05.003
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Spatiotemporal analysis reveals distinct inflammatory programs underlying chronic colitis

Jennifer Fransson, Chiara Sorini, Francisca Castillo, Yuhao Chi, Ning He, Martin Suarez-Alvarez, Maria Alejandra Ulloa, Rodrigo A. Morales Castro, Ali Okhovat, Hailey Sounart, Chiara Zagami, Rebeca F. Cardoso, Srustidhar Das, Stefania Giacomello, Anna Mechling, Charlotte R.H. Hedin, Philip Smith, Eduardo J. Villablanca

10.1016/j.immuni.2026.04.005
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Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress

Michael Scaglione, Montana Knight, Krittin Trihemasava, Kelly Rome, Anne-Sophie Archambault, Juhee Oh, Erin Tanaka, Elise Hall, Tran Ngoc Van Le, Caleb L. Lines, Brian Goldspiel, Hossein Fazelinia, Clemence Queriault, Lucien Turner, Tanay Parnaik, Jimmy Xu, Morgan Brown, Oishi Bardhan, Jessie Axsom, Frederick C. Bennett, Lynn A. Spruce, Caroline Bartman, Clementina Mesaros, Ramon I. Klein Geltink, Crystal S. Conn, Will Bailis

10.1016/j.immuni.2026.04.004
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Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer

Alina Ulezko Antonova, Patrick Fernandes Rodrigues, Chelsea Mannie, Giorgia Ferrari, Horacio Carvajal, Mattia Bugatti, William Vermi, Tong Wu, Marina Cella, Pirooz Eghtesady, Marco Colonna

10.1016/j.immuni.2026.04.003
View Publication

NK cell dysfunction and interferon gamma production underlie autoinflammation in mevalonate kinase deficiency

Marcia A. Munoz, Iona S. Schuster, James Cremasco, Etienne N. Masle-Farquhar, Oliver P. Skinner, Zoe J. Vandeleur, Maté Biro, Daryan Kempe, William D. Renton, Sam Mehr, Charlotte Abell-King, Szun Szun Tay, Ryan C. Chai, Samar Ojaimi, John J. Zaunders, Geetha Rao, Ariel Castro-Martinez, Lisette van de Corput, Andrew N. McCorkindale, Leonard D. Goldstein, Xiaohong Li, Flore Wouters, Daniel L. Kastner, Ignatius Chua, Nicole L. Fewings, Fiona C. McKay, Catharina M. Mulders-Manders, Robert A. Brink, Stuart G. Tangye, Ivona Aksentijevich, Cindy S. Ma, Jeroen van der Hilst, Joost Frenkel, Mariapia A. Degli-Esposti, Michael J. Rogers

10.1016/j.immuni.2026.03.027
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Frequently asked questions

How long does it take to publish?

Median 7 days from submission to first editorial decision and median 27 days from acceptance to online publication.

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Is a cover letter required?

A cover letter is included among the materials to prepare for submission.

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What are the publication costs?

Hybrid journal. Open access article publishing charge: $10,400.

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Research Topics

Immune Cell Function and Interaction T-cell and B-cell Immunology Immunotherapy and Immune Responses Immune Response and Inflammation IL-33, ST2, and ILC Pathways Immune cells in cancer interferon and immune responses CAR-T cell therapy research Monoclonal and Polyclonal Antibodies Research Inflammasome and immune disorders Cytokine Signaling Pathways and Interactions Cancer Immunotherapy and Biomarkers Neuroinflammation and Neurodegeneration Mechanisms NF-κB Signaling Pathways Cell Adhesion Molecules Research HIV Research and Treatment Diabetes and associated disorders Phagocytosis and Immune Regulation Gut microbiota and health Cytomegalovirus and herpesvirus research Immunodeficiency and Autoimmune Disorders Eosinophilic Esophagitis Immune responses and vaccinations vaccines and immunoinformatics approaches Neutrophil, Myeloperoxidase and Oxidative Mechanisms

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