JO

Journal Of Clinical Immunology

Journal of Clinical Immunology is an international journal that focuses on human immunology, particularly primary immunodeficiencies and related diseases. It publishes high impact papers exploring diagnosis, pathogenesis, prognosis, or treatment of human diseases; considers studies ranging from genetic discovery and clinical description to immunologic assessment, diagnostic approach, prognosis evaluation, and treatment intervention; and considers case reports of general significance.

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Subject Immunology
Impact Factor 5.7
Quartile Q1
Open Access Type Open
ISSN 0271-9142
eISSN 1573-2592
Invitation Only Yes
Cost Range Open access fees and any associated publication costs apply depending on the publishing model selected after acceptance.

Submission Instructions

Journal Of Clinical Immunology is an invitation-only journal. Submissions are accepted by invitation from the editorial board only. The following article types are accepted:

Original Article

Cover Letter An accompanying submission letter is required. The submission letter must state that all coauthors reviewed the manuscript and contributed in a substantive and intellectual manner, and it must mention any unpublished material included in the manuscript.
Abstract An abstract is required. Abstract must not exceed 250 words. Abstract must be unstructured as a single narrative paragraph with no subheadings or references.
Manuscript Manuscript text must not exceed 4,000 words excluding the abstract, tables, figure legends, and references. Manuscript should be ordered as Abstract, Introduction, Methods, Results, Discussion, Acknowledgements, Authorship Contributions, Disclosure of Conflicts of Interest, References, Tables, Figure Legends, and Figures. Manuscript must include 4 to 6 keywords, a disclosure statement, Authorship Contributions, a Disclosure of Conflicts of Interest section, a Statements and Declarations section before the references, documentation of any large language model use in the Methods section or another suitable section, and a data availability statement.
References A limit of 100 references is recommended. References must use Vancouver style. Citations in the text must be numbered in square brackets and the reference list must contain only cited published or accepted works numbered consecutively.
Figures & Tables Submissions are limited to a total of 7 figures. Figures should be submitted within the body of the text unless file size causes upload problems. Tables and figures must be numbered with Arabic numerals and cited in consecutive numerical order, and figure captions must be included in the manuscript text file.
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Cme Review Articles

Cover Letter A cover letter is required only to mention any unpublished material included in the manuscript and provide transparency on re-use of material. The submission letter must state that all coauthors reviewed the manuscript and contributed in a substantive and intellectual manner to the work described.
Abstract An abstract is required. Abstract must not exceed 250 words. Abstract must be unstructured as a single narrative paragraph with no subheadings or references.
Manuscript Manuscript text must not exceed 4,000 words excluding the abstract, tables, figure legends, and references. Manuscript should be ordered as title page, abstract, key words, introduction, methods, results, discussion, conclusions, appendix, acknowledgments, disclosure, references, tables, and figure-caption list. Manuscript must include 4 to 6 keywords, a disclosure statement, a Statements and Declarations section before the references, documentation of any large language model use in the Methods or another suitable section, and 5 multiple choice questions each with 1 correct answer and 4 distractors.
References Up to 100 references is recommended. References must use Vancouver style with numbered citations in square brackets. Reference list must include only cited published or accepted works, be numbered consecutively, use ISSN title abbreviations or full journal titles if unsure, and include full DOI links when available.
Figures & Tables Submissions are limited to a total of 7 figures. Figures should be submitted within the body of the text unless file size causes upload problems, and figure captions must be included in the manuscript text file. Figures must be supplied electronically as digital images and all figures and tables must be numbered with Arabic numerals and cited in consecutive numerical order.
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Letter To The Editor

Cover Letter A cover letter is required. The cover letter must state that all coauthors reviewed the manuscript and contributed in a substantive and intellectual manner, and it must mention any unpublished material included in the manuscript.
Abstract An abstract must not be included.
Manuscript The total manuscript length must not exceed approximately 1,200 words. The submission must begin with the salutation 'To the Editor'. Include 4 to 6 keywords and a 'Statements and Declarations' section before the references, and document any large language model use in the Methods section or another suitable part of the manuscript if no Methods section is available.
References The submission may include no more than 5 references. References must use Vancouver style. Citations in the text must be numbered in square brackets and the reference list must contain only cited published or accepted works numbered consecutively.
Figures & Tables The submission may include 1 figure or table, with additional figures or tables allowed as online supplemental data. Figures should be submitted within the body of the text unless file size causes upload problems. Figure captions must be included in the manuscript text file rather than in the figure file, and tables and figures must be numbered with Arabic numerals and cited in consecutive numerical order.
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“How I Manage” Articles

Cover Letter An accompanying submission letter is required. The submission letter must state that all coauthors have reviewed the manuscript and have contributed in a substantive and intellectual manner to the work described.
Abstract An abstract is required. Abstract must not exceed 250 words. Abstract structure is not specified. Abstract headings are not specified.
Manuscript Manuscript text must not exceed 4,000 words, excluding the abstract, tables, figure legends, and references. Organization into specific sections is left to the authors, although the article otherwise follows the instructions for Original Articles. The manuscript must include 4 to 6 keywords and a Statements and Declarations section before the references.
References A limit of 100 references is recommended. References must use Vancouver format. References must be cited in the text with numbers in square brackets and listed consecutively in numbered order.
Figures & Tables Submissions are limited to a total of 7 figures. Figures should be submitted within the body of the text unless file size causes upload problems. Figure captions must be included in the manuscript text file rather than in the figure files, and each table and figure must be numbered consecutively using Arabic numerals.
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Commentary

Cover Letter A submission letter must accompany the manuscript. The submission letter must state that all coauthors reviewed the manuscript and contributed in a substantive and intellectual manner, and it must mention any unpublished material included in the manuscript.
Abstract Abstract requirements are not specified.
Manuscript Commentary submissions must not exceed 1,500 words. The title must be clear and concise with a maximum length of 75 characters, and the manuscript must include a 1- to 2-sentence summary of the significance of the paper being editorialized to the readership. Commentary submissions must reference the paper being editorialized and include 4 to 6 keywords and a Statements and Declarations section before the references.
References Commentary submissions may include a maximum of 10 references. References must use Vancouver format with numbered citations in square brackets. The reference list must include only cited published or accepted works and be numbered consecutively, with journal titles abbreviated according to the ISSN list and full DOI links included when available.
Figures & Tables Commentary submissions may include one figure or table if needed. Figures should be submitted within the body of the text unless file size causes upload problems, and figure captions must be included in the manuscript text file. Tables and figures must be numbered in Arabic numerals and cited in consecutive numerical order, with each table or figure accompanied by a caption.
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Recent Publications

Bronchiectasis, Low IgG Levels and Lack of Vaccination are Risk Factors for Covid-19 Hospitalization in X-linked Agammaglobulinemia – A Retrospective Multicenter Study

Caroline Stenlander, Hannes Lindahl, Emelie Wahren-Borgström, Christoph B. Geier, Anna Sediva, Børre Fevang, Cinzia Milito, Cláudia Varandas, Cristina Roca-Oporto, Federica Pulvirenti, Isabel Hodl, Ivana Malkusova, Jacques G. Rivière, Jiri Litzman, Jolan E. Walter, Leif G. Hanitsch, Olaf Neth, Pavlina Kralickova, Rahim Miller, Serena Shaffren, Susana L. Silva, Terese Katzenstein, Timi Martelius, Urs C. Steiner, C. I. Edvard Smith, Klaus Warnatz, Peter Bergman

10.1007/s10875-025-01962-3
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Neurological Phenotypes of SOCS1 Haploinsufficiency: Insights from Functional and Histological Investigations

Serena Palmeri, Ignazia Prigione, Francesca Schena, Marie Jeanpierre, Arinna Bertoni, Federica Penco, Paola Bocca, Genny Del Zotto, Sara Massucco, Consuelo Venturi, Angelo Schenone, Gino Tripodi, Giada Recchi, Marina Lanciotti, Maurizio Miano, Caterina Matucci-Cerinic, Gianmaria Viglizzo, Riccardo Papa, Frédéric Rieux-Laucat, Roberta Caorsi, Marco Gattorno, Stefano Volpi

10.1007/s10875-025-01958-z
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The Spectrum of Bacterial Infection in a Large Cohort of Chinese Pediatric Patients with Inborn Errors of Immunity: A Nine-year, Retrospective, Single-center Study

Xiaodan Zhu, Pan Fu, Wenjie Wang, Wenjing Ying, Bijun Sun, Jia Hou, Xiaoying Hui, Jinqiao Sun, Chuanqing Wang, Qinhua Zhou, Xiaochuan Wang

10.1007/s10875-025-01964-1
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Evaluating Pediatric Reference Ranges for Extended Immunophenotyping from a Finnish Cohort against Published References

Elli Äärimaa, Anssi Kesäläinen, Samuel Askeli, Anne Toivonen, Okko Savonius, Oscar Brück, Pauliina Lusila, Kim Vettenranta, Santtu Heinonen, Timo Jahnukainen, Minna Koskenvuo, Sanna Siitonen, Sari Lehtimäki, Eliisa Kekäläinen

10.1007/s10875-025-01959-y
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STAT-1 gain-of-function CMC: Remission of Oral Candidiasis during PD-1 Inhibitor Treatment of Oral Cancer

Jannik Helweg-Larsen, Ditte Marie L. Saunte, Line Borgwardt, Claus Andrup Kristensen, Hanne Marquart

10.1007/s10875-025-01948-1
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Frequently asked questions

How long does it take to publish?

Submission to first decision (median): 17 days.

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Is a cover letter required?

A cover letter may include transparency on re-use of material and unpublished material included in the manuscript. Authors can suggest peer reviewers in the cover letter.

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What are the publication costs?

Any associated publication cost is arranged after acceptance, and open access fees depend on the publishing model selected.

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Research Topics

Immunodeficiency and Autoimmune Disorders Immune Cell Function and Interaction T-cell and B-cell Immunology Blood disorders and treatments Monoclonal and Polyclonal Antibodies Research Cytomegalovirus and herpesvirus research Immunotherapy and Immune Responses Chronic Lymphocytic Leukemia Research Platelet Disorders and Treatments Immune Response and Inflammation Systemic Lupus Erythematosus Research Neutrophil, Myeloperoxidase and Oxidative Mechanisms Cystic Fibrosis Research Advances Diabetes and associated disorders Cell Adhesion Molecules Research Inflammasome and immune disorders Autoimmune and Inflammatory Disorders Research HIV Research and Treatment Blood groups and transfusion Mycobacterium research and diagnosis NF-κB Signaling Pathways Pneumocystis jirovecii pneumonia detection and treatment Hematopoietic Stem Cell Transplantation interferon and immune responses Parvovirus B19 Infection Studies

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