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Laboratory Investigation

Laboratory Investigation is an international journal owned by the United States and Canadian Academy of Pathology and serves as its official journal. It publishes original research that advances the understanding and classification of human disease and offers both open access and subscription publishing options.

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Subject Medicine, Research & Experimental, Pathology
Impact Factor 4.2
Quartile Q2
Open Access Type Hybrid
ISSN 0023-6837
eISSN 1530-0307
Invitation Only No
Cost Range USD 4480 excl. taxes for open access articles; no open access publication fee for subscription articles

Submission Instructions

Laboratory Investigation accepts the following article types. Click on an article type to view submission instructions.

Research Article

Cover Letter Cover letter is required. Cover letter must provide full contact information for the corresponding author and declare any business relationships that might lead to a conflict of interest.
Abstract Abstract is required. Structured abstract must not exceed 300 words. Abstract must be structured. Abstract must use the headings Purpose, Materials and Methods, Results, and Conclusions.
Manuscript Main body text must not exceed 8000 words excluding the abstract, legends, and references. Manuscript must be divided into clearly defined sections and contain the essential elements including Introduction, Materials and Methods, Results, and Conclusions. Manuscript must include a summary declaration of interest statement, author contribution disclosures including that all authors approved the final article, a funding statement if no funding was received, subject terms, and an AI-use declaration at the end of the manuscript before the references if generative AI was used.
References Reference list must contain no more than 100 references. References must be cited numerically in the text and listed in numerical order. All authors must be listed for papers with up to six authors, papers with more than six authors must list the first three followed by et al., first and last page numbers must be provided, abstracts and letters must be identified as such, and journal names must be abbreviated using the List of Title Word Abbreviations.
Figures & Tables Research Articles may include a maximum of 6 tables and figures in total. Figures and tables in the submission file must be placed next to the relevant text with each caption directly below the figure or table. Tables must be submitted as editable text rather than images, figures and tables must be numbered consecutively in the order cited, and each illustration must have a caption explaining symbols and abbreviations.
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Review

Cover Letter Cover Letter requirements are not specified.
Abstract An unstructured abstract is required for Review articles. The abstract must not exceed 300 words. The abstract must be unstructured.
Manuscript The main body text must be no more than 8000 words, excluding the abstract, legends, and references. A declaration of generative AI use must be included at the end of the manuscript before the references if such tools were used in manuscript preparation.
References Review articles may include no more than 150 references. References must be cited in the text as numbers starting at 1 and listed at the end in numerical order, with all authors listed for up to six authors and the first three followed by et al. for more than six authors.
Figures & Tables Review articles may include a maximum of 5 tables and/or figures. Figures and tables in the submission file must be placed next to the relevant text, with each caption placed directly below the figure or table. Tables must be submitted as editable text rather than images, and each illustration must have a caption explaining symbols and abbreviations used.
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Correspondence

Cover Letter Cover letter is required. Cover letter must provide full contact information for the corresponding author and declare any business relationships that might lead to a conflict of interest.
Abstract Abstract is not required.
Manuscript Manuscript must not exceed 1000 words. Manuscript must be divided into clearly defined sections. Manuscript must include a summary declaration of interest statement and, if generative AI was used in manuscript preparation, a declaration statement at the end of the manuscript before the references list.
References References are limited to a maximum of 10. References must be cited in the text as numbers starting at one and listed at the end in numerical order, with all authors listed for papers with up to six authors and the first three authors followed by et al. for papers with more than six authors.
Figures & Tables Correspondence may include a maximum of 2 tables and/or figures. Figures and tables in the submission file must be placed next to the relevant text, with each caption directly below the figure or table. Each illustration must have a caption, and tables must be submitted as editable text rather than as images.
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Editorial

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is not required for editorials.
Manuscript Manuscript must not exceed 1000 words. A summary declaration of interest statement must be included in the manuscript, and if generative AI was used in manuscript preparation, a declaration statement must be placed at the end of the manuscript before the references list.
References Editorials may include a maximum of 10 references. References must be cited in the text as numbers starting at one and listed at the end in numerical order, with all authors listed for papers with up to six authors and only the first three followed by et al. for papers with more than six authors.
Figures & Tables Editorials may include a maximum of 2 tables and/or figures. Figures and tables in the submission file must be placed next to the relevant text in the manuscript, with each caption directly below the figure or table. Each illustration must have a caption, tables must be submitted as editable text rather than images, and figures must be numbered according to their sequence in the text.
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Recent Publications

Detection and Recurrence Risk Stratification of Gastric Cancer Through DNA Methylation Profiling of Blood

Jing Guo, Shun Zhang, Shuang Zhou, Hui Wang, Kehui Xie, Chengcheng Ma, Zhixi Su, Rui Liu, Haiyan Han, Yiqin Pan, Jin Tong, Zhiguo Xiong, Liang Cheng, Renquan Lu, Xiaohua Jiang, Dazhi Xu

10.1016/j.labinv.2026.106132
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Comparative immune profiling of murine and human pancreatic cancer precursors reveals species- and lesion-dependent immune microenvironments

L. Haeberle-Graser, M. Schulte, C. Mueller, S. Haensch, M. Schlensog, I. Esposito

10.1016/j.labinv.2026.106143
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Cross-Platform Comparative Spatial Transcriptomics in High-Grade Serous Carcinoma

Omar Youssef, Lars Selander, Shuyu Zheng, Lilla Csellar, Satu Hänninen, Jing Tang, Olli Carpén, Anna Ray Laury

10.1016/j.labinv.2026.106134
View Publication

Paired Tissue and ctDNA Profiling Reveals Novel ESR1 Amplifications CDK4/6 Resistance Mechanisms in HR+/HER2– Metastatic Breast Cancers

Liu Liu, Stephanie L. Graff, Liang Cheng, Yihong Wang

10.1016/j.labinv.2026.106135
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Immunohistochemical Assay Variability and HER2-low Breast Cancer Detection: A Laboratory Comparison in the Netherlands

Zeynep E. Kain, Emma Schuurman, Ximena Baez-Navarro, Henrik Høeg, Prasanth Kanneganti, Nils ’t Hart, Carolien H.M. van Deurzen

10.1016/j.labinv.2026.106136
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Frequently asked questions

How long does it take to publish?

Articles are made available online as soon as possible after acceptance as Journal Pre-proofs. Authors are asked to provide proof corrections within two days.

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Is a cover letter required?

A cover letter is expected. It should provide full contact information for the corresponding author, confirm that each author approves the submitted manuscript, state that the manuscript is not under consideration elsewhere, and declare any business relationships that might lead to a conflict of interest. Information about related submissions and why the work fits the journal is optional.

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What are the publication costs?

Open access APC: USD 4480 excluding taxes for all articles. Subscription publication: no open access publication fee.

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Research Topics

Cancer Genomics and Diagnostics AI in cancer detection Sarcoma Diagnosis and Treatment Radiomics and Machine Learning in Medical Imaging Lymphoma Diagnosis and Treatment Liver Disease Diagnosis and Treatment Pancreatic and Hepatic Oncology Research Breast Cancer Treatment Studies Cancer Cells and Metastasis Cell Adhesion Molecules Research Molecular Biology Techniques and Applications Genetic factors in colorectal cancer HER2/EGFR in Cancer Research Breast Lesions and Carcinomas Ovarian cancer diagnosis and treatment Biomedical and Engineering Education Liver physiology and pathology Endometrial and Cervical Cancer Treatments Conferences and Exhibitions Management Neuroendocrine Tumor Research Advances Big Data and Business Intelligence Cervical Cancer and HPV Research Prostate Cancer Treatment and Research Cancer-related molecular mechanisms research Cancer Immunotherapy and Biomarkers

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