NR

Nature Reviews Cardiology

Nature Reviews Cardiology publishes Reviews, Research Highlights, News & Views, Comments, Journal Club articles, Tools of the Trade articles, Milestones and related content focused on cardiovascular medicine and research.

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Subject Cardiac & Cardiovascular Systems
Impact Factor 44.2
Quartile Q1
Open Access Type Hybrid
ISSN 1759-5002
eISSN 1759-5010
Invitation Only Yes
Cost Range Subscription publication route only; no immediate gold open access option.

Submission Instructions

Nature Reviews Cardiology is an invitation-only journal. Submissions are accepted by invitation from the editorial board only. The following article types are accepted:

Review

Cover Letter Cover Letter requirements are not specified.
Abstract A 200-word abstract is required for the synopsis, and the article abstract must be unstructured. The abstract should ideally be no more than 200 words. The abstract must be unstructured.
Manuscript The synopsis must include a brief description of the main article sections, the introduction must be presented without subheadings, and the article must end with a brief concluding summary section without subheadings. The synopsis must include a list of key references and the list of authors with their affiliations, the manuscript must document any LLM use in the Methods section or another suitable section if no Methods section is available, and Review articles in Nature Reviews Cardiology must include 4–6 key point bullet points of 30 words or fewer each.
References References should be approximately 25 per 1,000 words. References must use Nature Reviews style. References must be cited as sequential superscript numbers in the order of main text, tables, figures and then boxes, and references with six or more authors should list only the first author followed by 'et al.'.
Figures & Tables Display items are limited to 7 or fewer tables, figures and boxes in total. Tables must be provided as part of the article document, while tables containing graphical content must be provided as separate image files. Display items must be cited in the main text in the format (FIG. 1), tables and boxes must have a short title, and figures must be fully labelled with a short title and a concise legend.
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Perspective

Cover Letter Cover Letter requirements are not specified.
Abstract A 200-word unstructured abstract is required for the synopsis and the abstract must not contain references or display item citations. The abstract must be 200 words. The abstract must be unstructured.
Manuscript The main text should follow word count recommendations discussed with the editor. The article must begin with an introduction without subheadings that ends with a guiding paragraph and must end with a brief concluding section without subheadings. Competing interests must be included in the manuscript file, and any use of an LLM must be documented in a suitable part of the manuscript if no Methods section is available.
References References should be approximately 25 references per 1,000 words. References must use Nature Reviews style. References must be cited as sequential superscript numbers and listed in the order of main text, tables, figures, and then boxes, with six or more authors shortened to the first author followed by 'et al.'.
Figures & Tables No more than 5 display items, including tables, figures and boxes, are allowed. Tables and boxes should be provided as part of the article document, while tables containing graphical content should be provided as separate image files. Tables must have a short title, no legend, entries in all cells, and defined abbreviations, and figures must be fully labelled with concise legends that include a short title, descriptions of all components, and definitions of all abbreviations.
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Consensus Statement

Cover Letter Cover Letter requirements are not specified.
Abstract A 200-word unstructured abstract is required in the synopsis. Abstract must be 200 words. Abstract must be unstructured.
Manuscript Manuscript must include an introductory section without subheadings, a Methods section describing methodology and stakeholders, and a brief concluding summary section without subheadings. The synopsis must include a brief description of the main article sections, a list of key references, and the list of authors and their affiliations, and any use of an LLM must be documented in the Methods section or another suitable part of the manuscript.
References References should be approximately 25 per 1,000 words, and highlighted key references should comprise 5–10% of the total references. References must use Nature Reviews style. References must be cited as superscript numbers in sequential order through the main text, tables, figures, and boxes, and references with six or more authors should list only the first author followed by 'et al.'.
Figures & Tables Display items are limited to 7 total tables, figures, and boxes. Tables must be provided as part of the article document, whereas tables containing graphical content must be provided as separate image files. Tables must have a short title with entries in all cells and defined abbreviations, figures must be fully labelled with a short title and concise legend, and tables must have no legend.
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Evidence-Based Guidelines

Cover Letter Cover Letter requirements are not specified.
Abstract A 200-word unstructured abstract is required in the synopsis. Abstract must be 200 words. Abstract must be unstructured.
Manuscript Manuscript must include an introduction without subheadings, a Methods section describing methodology and stakeholders, and a brief concluding summary section without subheadings. Synopsis must include a brief description of the main article sections, a list of key references, and the list of authors and their affiliations, and any use of an LLM must be documented in the Methods section or another suitable part of the manuscript.
References References should be approximately 25 per 1,000 words. References must use Nature Reviews style. References must be cited as sequential superscript numbers, and if a reference has six or more authors only the first author should be listed followed by 'et al.'.
Figures & Tables Display items are limited to 7 total tables, figures, and boxes. Tables must be provided as part of the article document, while tables containing graphical content must be provided as separate image files. Tables must have a short title, no legend, entries in all cells, and defined abbreviations, and each figure must be fully labelled with a short title and a concise legend defining all abbreviations.
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News & Views

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Main text should be around 1,000 words, and the main body plus one display item must fit on 2 print pages. Article must begin with a standfirst of up to 50 words and contain no headings. Only one simple and concise display item may be included, and competing interests must be declared within the article text.
References Manuscript may include a maximum of 10 references. References must use Nature Reviews style. References must be cited as sequential superscript numbers in the order of main text, tables, figures, and then boxes, and works with six or more authors should list only the first author followed by 'et al.'.
Figures & Tables Only one simple and concise display item may be included. Tables and boxes should be provided as part of the article document, whereas tables containing graphical content must be supplied as separate image files. Figures must be fully labelled with concise legends, and tables must be clear, simple, titled, contain entries in all cells, include definitions for all abbreviations, and have no legend.
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Correspondence

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Main text must not exceed 500 words. No more than two levels of headings are allowed, and the first paragraph must cite the original article. Competing interests must be declared within the text of the article, and any use of an LLM must be documented in the Methods section or another suitable part of the manuscript if no Methods section is available.
References References must not exceed 10. References must use Nature Reviews reference style. References must be cited as superscript numbers in sequential order through the main text, tables, figures and boxes, and references with six or more authors should list only the first author followed by 'et al.'.
Figures & Tables Only one display item can be included. Tables and boxes must be provided as part of the article document, while tables containing graphical content must be provided as separate image files. Tables must have a short title, all cells must contain an entry, abbreviations must be defined, and tables must not include a legend, while each figure must be fully labelled and include a short title and concise legend defining all abbreviations.
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Comment

Cover Letter Cover Letter requirements are not specified.
Abstract A 200-word abstract is required as part of the submission synopsis. The abstract must be 200 words.
Manuscript The main text should usually be around 500–600 words or around 1,000–1,200 words. The synopsis must include a brief description of the main article sections, and the Comment itself may use only one level of heading. Comments must include a standfirst of no more than 50 words, and any use of an LLM must be documented in the Methods section or another suitable part of the manuscript if no Methods section is available.
References Comments may include a maximum of 10 references. References must use Nature Reviews reference style. References must be cited as superscript numbers in sequential order through the main text, tables, figures and then boxes, and references with six or more authors should list only the first author followed by 'et al.'.
Figures & Tables Only one simple and concise display item may be included, and a single display item or supplementary information may be included at the editor’s discretion. Tables and boxes must be provided as part of the article document, while tables containing graphical content must be provided as separate image files. Tables must have a short title, no legend, at least three columns of data, entries in all cells, and definitions for all abbreviations, while figures must be fully labelled with a short title and a concise legend.
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Recent Publications

Heart-specific T cell responses: from antigens to disease mechanisms

Gustavo Campos Ramos

10.1038/s41569-026-01356-x
View Publication

Beyond glucose lowering and ketogenesis: unveiling new cardioprotective mechanisms of SGLT2 inhibitors

Alessia Riccio, Gaetano Santulli

10.1038/s41569-026-01357-w
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Global burden of venous thromboembolism: incidence and outcome estimates of deep-vein thrombosis and pulmonary embolism

Behnood Bikdeli, Sina Rashedi, Mariana Pfeferman, Christopher Amalan, Hannah Leyva, Darsiya Krishnathasan, Syed Bukhari, Burton H. Shen, Eric A. Secemsky, Zhenguo Zhai, Yugo Yamashita, Mitsuaki Sawano, Pantep Angchaisuksiri, David Jimenez, Manuel Monreal, Parham Sadeghipour, Marco Zuin, Laurent Bertoletti, Eduardo Ramacciotti, Frederikus A. Klok, Faizan Khan, Harry Gibbs, Stefano Barco, Jean Jacques Noubiap, Samuel Z. Goldhaber, Alexander T. Cohen, Gregory Y. H. Lip, Jean M. Connors, Jeffrey I. Weitz, Lisa K. Moores, Andrei Kindzelski, George A. Mensah, Mary Cushman, Harlan M. Krumholz, Gregory Piazza

10.1038/s41569-026-01334-3
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Beating the odds: bringing the human heart into a dish

Marcos Castro-Guarda, Jolanda van der Velden

10.1038/s41569-026-01355-y
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Benefit of aficamten in non-obstructive hypertrophic cardiomyopathy

Gregory B. Lim

10.1038/s41569-026-01353-0
View Publication

Frequently asked questions

How long does it take to publish?

Accepted manuscripts may be self-archived for public release 6 months after first publication.

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What are the publication costs?

Research Topics

Atrial Fibrillation Management and Outcomes Cardiac Imaging and Diagnostics Cardiovascular Function and Risk Factors Coronary Interventions and Diagnostics Cardiac Arrhythmias and Treatments Lipoproteins and Cardiovascular Health Cardiac Valve Diseases and Treatments Antiplatelet Therapy and Cardiovascular Diseases Cardiac electrophysiology and arrhythmias Cardiac pacing and defibrillation studies Acute Myocardial Infarction Research Heart Failure Treatment and Management Venous Thromboembolism Diagnosis and Management Blood Pressure and Hypertension Studies Atherosclerosis and Cardiovascular Diseases Cardiomyopathy and Myosin Studies Diabetes, Cardiovascular Risks, and Lipoproteins Cerebrovascular and Carotid Artery Diseases Mechanical Circulatory Support Devices Cardiac Fibrosis and Remodeling Cardiac, Anesthesia and Surgical Outcomes Heart Rate Variability and Autonomic Control Cardiac Arrest and Resuscitation Infective Endocarditis Diagnosis and Management Cardiac Structural Anomalies and Repair

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