ST

Science Translational Medicine

Science Translational Medicine is a weekly online journal publishing research at the intersection of science, engineering, and medicine. Its goal is to promote human health by providing a forum for communicating the latest research advances from biomedical, translational, and clinical researchers across established and emerging disciplines relevant to medicine.

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Subject Medicine, Research & Experimental
Impact Factor 14.6
Quartile Q1
Open Access Type Closed
ISSN 1946-6234
eISSN 1946-6242
Invitation Only Yes
Cost Range Individual access is available through an add-on subscription or membership upgrade. Research articles become free with registration one year after publication.

Submission Instructions

Science Translational Medicine is an invitation-only journal. Submissions are accepted by invitation from the editorial board only. The following article types are accepted:

Research Articles

Cover Letter A cover letter is required for Research Articles. The cover letter must include the paper title, a statement of the main point, information needed for fair review including related manuscripts submitted elsewhere, names of colleagues who reviewed the paper, a statement that none of the material has been published or is under consideration elsewhere including on the Internet, and any AI-use disclosure.
Abstract Research Articles must include an abstract. The abstract should preferably be 125 words or fewer. The abstract is unstructured. The abstract must explain why the research was done, what was found, and why the results are important.
Manuscript Research Articles should be no more than 10,000 words including main text, references, and figure legends. Research Articles must be organized as Title, Abstract, Introduction, Results, Discussion, Materials and Methods, References, Figures and Figure Legends, Tables and Table Legends, and Supplementary Materials, with the manuscript assembled in the order Title, One Sentence Summary, Authors, Affiliations, Abstract, Main Text, References and Notes, Acknowledgements, figure captions, table captions, and Supplementary Materials. Research Articles must include a one-sentence summary, an Experimental Design or Study Design section at the start of Materials and Methods, a Statistical Analysis section at the end, complete Acknowledgments with funding, author contributions, competing interests, and data/materials availability, supplementary item listings with titles, and AI-use disclosure in the manuscript methods or acknowledgments if applicable.
References References and Notes must be numbered in the order first cited through the text, then figure and table legends, and finally Supplementary Materials, with each reference listed only once and journal article references including the full author list, full title, and inclusive pagination.
Figures & Tables Research Articles may have up to 8 figures and tables combined. Tables must be included after the references, figure legends must be included in the text file immediately after each figure, figures are to be embedded in the Word file for online submission except large files may be submitted separately, and initial supplementary materials must be submitted as a separate .docx or .pdf file. All figures and tables must be cited and numbered in numerical order, each figure and table must have a legend beginning with a brief title, figures assembled from multiple images must show borders between parts, and units must be provided in tables and figures using SI units.
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Reviews

Cover Letter A cover letter must disclose any use of AI-assisted technologies in the research study or in the writing or presentation of the manuscript. The cover letter must include disclosure of any use of AI-assisted technologies in the research study or in the writing or presentation of the manuscript.
Abstract An abstract is required. Abstract must be 100 words or less.
Manuscript Manuscript must be no more than 8000 words including abstract, main text, references, and figure legends. Any use of AI-assisted technologies must also be disclosed in the methods section or acknowledgments section of the manuscript.
References References must not exceed 100.
Figures & Tables The submission may include up to four figures with figure legends or tables.
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Research Resources

Cover Letter If AI-assisted technologies were used in the research, writing, or presentation, this must be disclosed in the cover letter.
Abstract Abstract requirements are not specified.
Manuscript Research Resources must use the same format as Research Articles. If AI-assisted technologies were used, this must be disclosed in the methods section or acknowledgments section of the manuscript.
References Unpublished data and personal communications must not be used to support significant claims in the paper.
Figures & Tables Figures & Tables requirements are not specified.
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Recent Publications

A 5 + 1 polyene scaffold that selectively recognizes ergosterol’s conjugated diene uncouples antifungal potency from host toxicity

Wei Liu, Qisen Deng, Feng Tang, Wenbo Zhu, Han Zhang, Tao Chen, Wen Xiao, Wenyan He, Nan Liu, Zongqiang Wang

10.1126/scitranslmed.aei5968
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A fluorescent choline kinase alpha inhibitor for intraoperative molecular imaging during resection of canine NSCLC tumors

Sofya A. Osharovich, David E. Holt, Michael C. Hart, Ritesh K. Isuri, Jennifer L. Huck, Stefan Harmsen, Charles-Antoine Assenmacher, Enrico Radaelli, Sean Carlin, Alex C. Watts, Maureen A. Griffin, Heather Scavello, Wei-Ting Hwang, Anatoliy V. Popov, Sunil Singhal, Edward J. Delikatny

10.1126/scitranslmed.aea4947
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The kinase inhibitor dabrafenib halts progression of cerebral cavernous malformations in a BRAF-independent manner

Maximiliano Arce, Hua Huang, Charlotte Rorsman, Iza Erzar, Joppe Oldenburg, Ying Sun, Ross Smith, Favour C. Onyeogaziri, Stefano Barbera, Frida C. Ahlstrand, Petter Ranefall, Anna Klemm, Mark Richards, Anna Dimberg, Lena Claesson-Welsh, Peetra U. Magnusson

10.1126/scitranslmed.adr0448
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Single-nucleotide polymorphism–directed design of allele-specific antisense oligonucleotides for spinocerebellar ataxia type 3

Jacob Helm, Elena Buena-Atienza, Clemens M. Sauter, Linus Wiora, Melanie Kraft, Yvonne Schelling, Jakob Admard, Jeannette Hübener-Schmid, Thomas Klockgether, Matthis Synofzik, Luís Pereira de Almeida, Mafalda Raposo, Paola Giunti, Hector Garcia-Moreno, Magda M. Santana, Jennifer Faber, Holger Hengel, Nicolas Casadei, Ludger Schöls, Stefan Hauser

10.1126/scitranslmed.adz2140
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Graft-versus-host disease prophylaxis shapes T cell biology and immune reconstitution after hematopoietic cell transplant

Susan DeWolf, Steven J. Siegel, Joseph Schmalz, Wael Saber, Alexandre Albanese, Jiayi Dong, Michael J. Martens, Brent Logan, Lorenzo Iovino, Kayleigh Ingersoll-Ohmdahl, Nicholas Winn, Edward Chen, James Kaminski, Donna Neuberg, Kyle Hebert, Paula Keskula, Jillian Zavistaski, Lea Steinberg, Isabella Schichter, Zoe Katsamakis, Lorenzo Cagnin, Vanessa Hernandez, Makya Warren, Kristy Applegate, Merav Bar, Saurabh Chhabra, Sung Won Choi, William Clark, Suman Das, Robert Jenq, Richard J. Jones, John E. Levine, Hemant Murthy, Armin Rashidi, Marcie Riches, Karamjeet Sandhu, Anthony D. Sung, Karilyn Larkin, Monzr M. Al Malki, Mahasweta Gooptu, Hany Elmariah, Amin Alousi, Lyndsey Runaas, Brian Shaffer, Andrew Rezvani, Najla El Jurdi, Alison W. Loren, Danielle Scheffey, Catherine Sanders, Mehdi Hamadani, Jarrod A. Dudakov, Stephanie Bien, Harlan Robins, Mary Horowitz, Javier Bolaños-Meade, Shernan Holtan, Ami S. Bhatt, Miguel-Angel Perales, Leslie S. Kean

10.1126/scitranslmed.aef7406
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Frequently asked questions

How long does it take to publish?

Original research papers are freely accessible with registration 12 months after publication.

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Is a cover letter required?

Authors who use AI-assisted technologies as aids in writing or presentation should disclose this in the cover letter and in the methods section or acknowledgments, depending on use case.

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What are the publication costs?

Individual access is available through an add-on subscription or membership upgrade.

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Research Topics

Immune Cell Function and Interaction CAR-T cell therapy research Immunotherapy and Immune Responses T-cell and B-cell Immunology SARS-CoV-2 and COVID-19 Research Cancer Immunotherapy and Biomarkers Cancer Genomics and Diagnostics Immune cells in cancer Epigenetics and DNA Methylation Monoclonal and Polyclonal Antibodies Research Virus-based gene therapy research HIV Research and Treatment Diet and metabolism studies Pancreatic function and diabetes Gut microbiota and health Alzheimer's disease research and treatments Neuroinflammation and Neurodegeneration Mechanisms CRISPR and Genetic Engineering Adipose Tissue and Metabolism Mosquito-borne diseases and control RNA Interference and Gene Delivery Immune Response and Inflammation Health and Medical Research Impacts Mitochondrial Function and Pathology Neuroscience and Neuropharmacology Research

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