ST

Science Translational Medicine

Science Translational Medicine is a weekly online journal publishing research at the intersection of science, engineering, and medicine. Its goal is to promote human health by providing a forum for communicating the latest research advances from biomedical, translational, and clinical researchers across established and emerging disciplines relevant to medicine.

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Subject Medicine, Research & Experimental
Impact Factor 14.6
Quartile Q1
Open Access Type Closed
ISSN 1946-6234
eISSN 1946-6242
Invitation Only Yes
Cost Range Individual access is available through an add-on subscription or membership upgrade. Research articles become free with registration one year after publication.

Submission Instructions

Science Translational Medicine is an invitation-only journal. Submissions are accepted by invitation from the editorial board only. The following article types are accepted:

Research Articles

Cover Letter A cover letter is required for Research Articles. The cover letter must include the paper title, a statement of the main point, information needed for fair review including related manuscripts submitted elsewhere, names of colleagues who reviewed the paper, a statement that none of the material has been published or is under consideration elsewhere including on the Internet, and any AI-use disclosure.
Abstract Research Articles must include an abstract. The abstract should preferably be 125 words or fewer. The abstract is unstructured. The abstract must explain why the research was done, what was found, and why the results are important.
Manuscript Research Articles should be no more than 10,000 words including main text, references, and figure legends. Research Articles must be organized as Title, Abstract, Introduction, Results, Discussion, Materials and Methods, References, Figures and Figure Legends, Tables and Table Legends, and Supplementary Materials, with the manuscript assembled in the order Title, One Sentence Summary, Authors, Affiliations, Abstract, Main Text, References and Notes, Acknowledgements, figure captions, table captions, and Supplementary Materials. Research Articles must include a one-sentence summary, an Experimental Design or Study Design section at the start of Materials and Methods, a Statistical Analysis section at the end, complete Acknowledgments with funding, author contributions, competing interests, and data/materials availability, supplementary item listings with titles, and AI-use disclosure in the manuscript methods or acknowledgments if applicable.
References References and Notes must be numbered in the order first cited through the text, then figure and table legends, and finally Supplementary Materials, with each reference listed only once and journal article references including the full author list, full title, and inclusive pagination.
Figures & Tables Research Articles may have up to 8 figures and tables combined. Tables must be included after the references, figure legends must be included in the text file immediately after each figure, figures are to be embedded in the Word file for online submission except large files may be submitted separately, and initial supplementary materials must be submitted as a separate .docx or .pdf file. All figures and tables must be cited and numbered in numerical order, each figure and table must have a legend beginning with a brief title, figures assembled from multiple images must show borders between parts, and units must be provided in tables and figures using SI units.
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Reviews

Cover Letter A cover letter must disclose any use of AI-assisted technologies in the research study or in the writing or presentation of the manuscript. The cover letter must include disclosure of any use of AI-assisted technologies in the research study or in the writing or presentation of the manuscript.
Abstract An abstract is required. Abstract must be 100 words or less.
Manuscript Manuscript must be no more than 8000 words including abstract, main text, references, and figure legends. Any use of AI-assisted technologies must also be disclosed in the methods section or acknowledgments section of the manuscript.
References References must not exceed 100.
Figures & Tables The submission may include up to four figures with figure legends or tables.
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Research Resources

Cover Letter If AI-assisted technologies were used in the research, writing, or presentation, this must be disclosed in the cover letter.
Abstract Abstract requirements are not specified.
Manuscript Research Resources must use the same format as Research Articles. If AI-assisted technologies were used, this must be disclosed in the methods section or acknowledgments section of the manuscript.
References Unpublished data and personal communications must not be used to support significant claims in the paper.
Figures & Tables Figures & Tables requirements are not specified.
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Recent Publications

Use of split intein and myotropic AAV vectors enables effective preclinical gene therapy for dysferlinopathy

Nikki M. McCormack, Stephanie Lee-Diaz, Theodore R. Reyes, Marshall W. Hogarth, Jada L. Covington, Camryn A. Bragg, Zarek O. Harper, Thomas Diehn, James S. Novak, Christine L. Halbert, Jeffrey S. Chamberlain, David L. Mack, Martin K. Childers, Jyoti K. Jaiswal, Hichem Tasfaout

10.1126/scitranslmed.aei5938
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Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis

Hung-Ju Chueh, Antigoni Katsikoudi, Ana Aragón-González, Chor Lai Lam, Liezel Tamon, Ashwin Jainarayanan, Devika Agarwal, Sally A. Cowley, David Sims, George K. Tofaris

10.1126/scitranslmed.adz9258
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Aberrant erythrocyte rigidity in JAK2 V617F myeloproliferative neoplasms underlies concurrent thrombosis and hemorrhage

Aae Suzuki, Liang Zhao, Chelsea Thorsheim, Brittany Weiderhold, Changsong Yang, Valerie Tutwiler, Carla Casu, Jacob W. Myerson, Elizabeth O. Hexner, Narla Mohandas, Vladimir R. Muzykantov, Rustem I. Litvinov, Chandrasekaran Nagaswami, Rebecca A. Risman, Peng Ji, Timothy J. Stalker, Aaron R. Goldman, Hsin-Yao Tang, David W. Speicher, Paul A. Janmey, Stefano Rivella, Wei Tong, John W. Weisel, Tatyana M. Svitkina, Charles S. Abrams

10.1126/scitranslmed.adt0044
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Immunoregulatory artificial lymph nodes restore antigen-specific tolerance in advanced multiple sclerosis

Jingsen Ji, Xinhuan Wang, Lu Liu, Jing Zhang, Jiaqing Wan, Gengyou Li, Guangting Xie, Jingyu Qi, Leyan Xuan, Yuying Yao, Fangling Liao, Xiaobao Cao, Ya Liu, Qi Gu, Xing-Jie Liang, Weisheng Guo

10.1126/scitranslmed.aea7960
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Transient receptor potential channel activation targets multiple stages of the schistosome parasite

Shashank Kulkarni, Sang-Kyu Park, Youssef Hamway, Lukas Friedrich, Jesko Kaiser, Evgeny G. Chulkov, Claudia M. Rohr, Cécile Häberli, Martin Horn, Tobias Hyun Ho Bäurle, Mario Pellegatti, Gary Grosser, Axel Becker, Rana Afshar, Andreas Becker, Nico Alexander Mell, Floriane Lignet, Philip Hewitt, Annika Hansen, Christian Brenneis, Jan Dvorak, Clarissa Prazeres da Costa, Jennifer Keiser, Jonathan S. Marchant, Thomas Spangenberg

10.1126/scitranslmed.aed8353
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Frequently asked questions

How long does it take to publish?

Original research papers are freely accessible with registration 12 months after publication.

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Is a cover letter required?

Authors who use AI-assisted technologies as aids in writing or presentation should disclose this in the cover letter and in the methods section or acknowledgments, depending on use case.

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What are the publication costs?

Individual access is available through an add-on subscription or membership upgrade.

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Research Topics

Immune Cell Function and Interaction CAR-T cell therapy research Immunotherapy and Immune Responses T-cell and B-cell Immunology SARS-CoV-2 and COVID-19 Research Cancer Immunotherapy and Biomarkers Cancer Genomics and Diagnostics Immune cells in cancer Epigenetics and DNA Methylation Monoclonal and Polyclonal Antibodies Research Virus-based gene therapy research HIV Research and Treatment Diet and metabolism studies Pancreatic function and diabetes Gut microbiota and health Alzheimer's disease research and treatments Neuroinflammation and Neurodegeneration Mechanisms CRISPR and Genetic Engineering Adipose Tissue and Metabolism Mosquito-borne diseases and control RNA Interference and Gene Delivery Immune Response and Inflammation Health and Medical Research Impacts Mitochondrial Function and Pathology Neuroscience and Neuropharmacology Research

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