ST

Science Translational Medicine

Science Translational Medicine is a weekly online journal publishing research at the intersection of science, engineering, and medicine. Its goal is to promote human health by providing a forum for communicating the latest research advances from biomedical, translational, and clinical researchers across established and emerging disciplines relevant to medicine.

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Subject Medicine, Research & Experimental
Impact Factor 14.6
Quartile Q1
Open Access Type Closed
ISSN 1946-6234
eISSN 1946-6242
Invitation Only Yes
Cost Range Individual access is available through an add-on subscription or membership upgrade. Research articles become free with registration one year after publication.

Submission Instructions

Science Translational Medicine is an invitation-only journal. Submissions are accepted by invitation from the editorial board only. The following article types are accepted:

Research Articles

Cover Letter A cover letter is required for Research Articles. The cover letter must include the paper title, a statement of the main point, information needed for fair review including related manuscripts submitted elsewhere, names of colleagues who reviewed the paper, a statement that none of the material has been published or is under consideration elsewhere including on the Internet, and any AI-use disclosure.
Abstract Research Articles must include an abstract. The abstract should preferably be 125 words or fewer. The abstract is unstructured. The abstract must explain why the research was done, what was found, and why the results are important.
Manuscript Research Articles should be no more than 10,000 words including main text, references, and figure legends. Research Articles must be organized as Title, Abstract, Introduction, Results, Discussion, Materials and Methods, References, Figures and Figure Legends, Tables and Table Legends, and Supplementary Materials, with the manuscript assembled in the order Title, One Sentence Summary, Authors, Affiliations, Abstract, Main Text, References and Notes, Acknowledgements, figure captions, table captions, and Supplementary Materials. Research Articles must include a one-sentence summary, an Experimental Design or Study Design section at the start of Materials and Methods, a Statistical Analysis section at the end, complete Acknowledgments with funding, author contributions, competing interests, and data/materials availability, supplementary item listings with titles, and AI-use disclosure in the manuscript methods or acknowledgments if applicable.
References References and Notes must be numbered in the order first cited through the text, then figure and table legends, and finally Supplementary Materials, with each reference listed only once and journal article references including the full author list, full title, and inclusive pagination.
Figures & Tables Research Articles may have up to 8 figures and tables combined. Tables must be included after the references, figure legends must be included in the text file immediately after each figure, figures are to be embedded in the Word file for online submission except large files may be submitted separately, and initial supplementary materials must be submitted as a separate .docx or .pdf file. All figures and tables must be cited and numbered in numerical order, each figure and table must have a legend beginning with a brief title, figures assembled from multiple images must show borders between parts, and units must be provided in tables and figures using SI units.
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Reviews

Cover Letter A cover letter must disclose any use of AI-assisted technologies in the research study or in the writing or presentation of the manuscript. The cover letter must include disclosure of any use of AI-assisted technologies in the research study or in the writing or presentation of the manuscript.
Abstract An abstract is required. Abstract must be 100 words or less.
Manuscript Manuscript must be no more than 8000 words including abstract, main text, references, and figure legends. Any use of AI-assisted technologies must also be disclosed in the methods section or acknowledgments section of the manuscript.
References References must not exceed 100.
Figures & Tables The submission may include up to four figures with figure legends or tables.
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Research Resources

Cover Letter If AI-assisted technologies were used in the research, writing, or presentation, this must be disclosed in the cover letter.
Abstract Abstract requirements are not specified.
Manuscript Research Resources must use the same format as Research Articles. If AI-assisted technologies were used, this must be disclosed in the methods section or acknowledgments section of the manuscript.
References Unpublished data and personal communications must not be used to support significant claims in the paper.
Figures & Tables Figures & Tables requirements are not specified.
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Recent Publications

SGLT2 inhibition modulates metabolic, vascular, and inflammatory molecular markers in the kidney in youth with type 1 diabetes

Petter Bjornstad, Ye Ji Choi, Phoom Narongkiatikhun, Anil Karihaloo, Pottumarthi V. Prasad, Lu-Ping Li, Kalie L. Tommerdahl, Maninderpal Sethi, Shivani Ramesh, Carissa Birznieks, Antoine Clarke, Yesmino Elia, Jacqueline Curtis, Cheril Clarson, Dylan Weissenkampen, Matteo D’Antonio, Jairo Arturo Pinzon Cortes, Hailey Hampson, Long Yuan, Sarah A. van Eeghen, Jenny E. Kanter, Karin E. Bornfeldt, Tomas Vaisar, Patricia Ladd, Hiddo J. L. Heerspink, Ian H. de Boer, Jesse A. Goodrich, Kelly Street, Katherine R. Tuttle, Kelly R. Bergmann, Cathy Smith, Jeffrey B. Hodgin, Jennifer A. Schaub, Viji Nair, Rajasree Menon, Abhijit S. Naik, Phillip J. McCown, Fadhl AlAkwaa, Sean Eddy, Edgar Otto, Nan Hee Kim, Robert G. Nelson, Victor G. Puelles, Daniël H. van Raalte, David Z. I. Cherney, Laura Pyle, Farid H. Mahmud, Matthias Kretzler

10.1126/scitranslmed.aee1005
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At-home wearable measurements provide detailed growth charts of infant early gross motor development

Manu Airaksinen, Elisa Taylor, Taru Palsa, Sofie de Sena, Leena Haataja, Sampsa Vanhatalo

10.1126/scitranslmed.adz7035
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Anti-CD20 B cell depletion is associated with elevated mucosal-originating circulating regulatory IgA B cells in multiple sclerosis

Tradite Neziraj, Elisabeth Pössnecker, Angela A. Wang, Paul Saary, Adrian-Minh Schumacher, Florian Ingelfinger, Amandine Mathias, Edoardo Galli, Marco Häfelfinger, Michelle Zuo, Samuel Jones, Vasiliki Pantazou, Joep Killestein, Sabine Schädelin, Pascal Benkert, Cristina Granziera, Caroline Pot, Antje Bischof, Jan Hendrik Niess, Magdalena Filipowicz Sinnreich, Tobias Derfuss, Charlotte E. Teunissen, Jens Kuhle, David A. Hafler, Renaud Du Pasquier, Yoshiaki Yasumizu, Jennifer L. Gommerman, Anne-Katrin Pröbstel

10.1126/scitranslmed.aee1580
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Premature senescence impairs hematopoietic stem cell function during sickle cell disease in mice and humans

Aditya Barve, Preeti Dabas, Adam Cornwell, Pramika Sriram, Alex Kopyov, Mattieu Zhai, Emilia Kooienga, Zakiya Kelley, James Johnson, Jacquelyn A. Myers, Esther A. Obeng, Guolian Kang, Yunusa Olufadi, Terri Cain, Lindsay Talbot, David Spence, Mauricio Cortes, Samuel A. Miller, Dirk Loeffler, Akshay Sharma, Shannon McKinney-Freeman

10.1126/scitranslmed.adv0628
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Complement augments antibody neutralization of SARS-CoV-2 variants

Martin Jungbauer-Groznica, Pierre Rosenbaum, Isabelle Staropoli, Florence Guivel-Benhassine, Pierre-Henri Commere, Tom Perisse, Lily Bruyère, Aura Fantin Rengifo, Alejandro De Cruz, Andrea Cottignies-Calamarte, Sabina Andreu, Laurent Hocqueloux, Thierry Prazuck, Cyril Planchais, Michael White, Sophie Novault, Sophie Trouillet-Assant, Slim Fourati, Nicolas de Prost, Martin Killian, Stéphane Paul, Olivier Schwartz, Hugo Mouquet, Timothée Bruel, Pierre Bay, Keyvan Razazi, Armand Mekontso Dessap, Lucile Picard, Nicolas Mongardon, Alexandre Soulier, Melissa N'debi, Sarah Seng, Mohamed Ader, Pierre Cappy, Christophe Rodriguez, Jean-Michel Pawlotsky, Etienne Audureau, Pierre-Andre Natella, Frederic Pene, Anne-Sophie L'honneur, Adrien Joseph, Elie Azoulay, Megan Fraisse, Maud Salmona, Marie-Laure Chaix, Charles-Edouard Luyt, David Levy, Julien Mayaux, Stephane Marot, Juliette Bernier, Vincent Bonny, Tomas Urbina, Hafid Ait-Oufella, Eric Maury, Laurence Morand-Joubert, Djeneba Bocar Fofana, Jean-Francois Timsit, Diane Descamps, Quentin Le Hingrat, Guillaume Voiriot, Nina De Montmollin, Mathieu Turpin, Stéphane Gaudry, Ségolène Brichler, Fabrice Uhel, Damien Roux, Luce Landraud, Anne-Claire Maherault, Tài Olivier Pham, Amal Chaghouri, Anne-Marie Roque-Alfonso, Nicholas Heming, Djillali Annane, Marie-Alice Bovy, Sylvie Meireles, Antoine Vieillard-Baron, Elyanne Gault, Sébastien Jochmans, Aurélia Pitsch, Guillaume Chevrel, Céline Clergue, Kubab Sabah, Damien Contou, Amandine Henry, Malo Emery, Claudio Garcia-Sanchez, Ferhat Meziani, Louis-Marie Jandeaux, Samira Fafi-Kremer, Elodie Laugel, Sébastien Preau, Raphaël Favory, Claire Bourel, Côme Bureau, Estelle Danche, Alexandre Gaudet, Geoffrey Ledoux, Aurélie Guigon, Antoine Kimmoun, Evelyne Schvoerer, Cédric Hartard, Charles Damoisel, Anne-Marie Roque-Alfonso, Nicolas Brechot, Hélène Péré, Antoine Guillon, Lynda Handala, François Beloncle, Achille Kouachet, Mathilde Taillantou-Candau, Caroline Lefeuvre, Alexandra Ducancelle, Rémi Coudroy, Arnaud W. Thille, François Arrive, Sylvain Le Pape, Laura Marchasson, Luc Deroche, Nicolas Leveque, Jean-Marc Tadié, Valentin Coirier, Vincent Thibault, Claire Grolhier, Béatrice La Combe, Séverine Haouisee, Alexandre Boyer, Sonia Burrel, Fabienne Tamion, Gaetan Beduneau, Christophe Girault, Maximillien Grall, Dorothée Carpentier, Alice Moisan, Elodie Alessandri-Gradt, Véronique Lemee, Adeline Baron, Marie Gueudin, Emmanuel Canet, Audrey Rodallec, Berthe Marie Imbert, Clément Saccheri, Géraldine Gonfrier, Sami Hraeich, Pierre-Edouard Fournier, Philippe Colson, Cédric Darreau, Jean Thomin, Anaïs Dartevel, Sylvie Larrat, Raphaele Germi, Aurelie Truffot, Guillaume Thiery, Sylvie Pillet, Kada Klouche, Ilka Engelmann, Edouard Tuaillon, Cécile Aubron, Adissa Tran, Sophie Vallet, Pierre-Emmanuel Charles, Alexis De Rougemont, Bertrand Souweine, Cecile Henquell, Audrey Mirand, Bruno Mourvillier, Laurent Andreoletti, Quentin Lecomte-Thenot, Damien Du Cheyron, Nefert Candace Dossou, Astrid Vabret, Gaël Piton, Jean-Christophe Navellou, Quentin Lepiller, Thomas Daix, Sébastien Hantz, Sylvie Roger, Benjamine Sarton, Camille Vellas, Claire Roger, Robin Stephan, Guillaume Louis, Christelle Jost, Pascale Perez, Sébastien Gibot, Evelyne Schvoerer, François Barbier, Jerome Guinard, Véronique Avettand-Fenoel, Jean-Philippe Rigaud, Elodie Blondel, Amélie Renou, Laurent Souply, Hossein Mehdoui, Laurence Fagour, Hugues Georges, Pierre Patoz, Asaël Berger, Julien Exinger, Jean-Christophe Richard, Alexandre Gaymard, François Danion, Manuel Etienne, Anne-Laure Mounayar, Matthieu Buscot, David Luque-Paz, Paul Loubet, Romaric Larcher, Myriam Chiaruzzi, Aurélie Martin, Marie Poupard, Fanny Villa, Guillaume Martin-Blondel, Florence Ader, Emmanuel Faure, Giovanna Melica, Nathan Peiffer-Smadja, Aurélien Dinh, Karine Lacombe

10.1126/scitranslmed.aec6027
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Frequently asked questions

How long does it take to publish?

Original research papers are freely accessible with registration 12 months after publication.

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Is a cover letter required?

Authors who use AI-assisted technologies as aids in writing or presentation should disclose this in the cover letter and in the methods section or acknowledgments, depending on use case.

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What are the publication costs?

Individual access is available through an add-on subscription or membership upgrade.

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Research Topics

Immune Cell Function and Interaction CAR-T cell therapy research Immunotherapy and Immune Responses T-cell and B-cell Immunology SARS-CoV-2 and COVID-19 Research Cancer Immunotherapy and Biomarkers Cancer Genomics and Diagnostics Immune cells in cancer Epigenetics and DNA Methylation Monoclonal and Polyclonal Antibodies Research Virus-based gene therapy research HIV Research and Treatment Diet and metabolism studies Pancreatic function and diabetes Gut microbiota and health Alzheimer's disease research and treatments Neuroinflammation and Neurodegeneration Mechanisms CRISPR and Genetic Engineering Adipose Tissue and Metabolism Mosquito-borne diseases and control RNA Interference and Gene Delivery Immune Response and Inflammation Health and Medical Research Impacts Mitochondrial Function and Pathology Neuroscience and Neuropharmacology Research

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