AJ

American Journal of Physiology-Gastrointestinal and Liver Physiology

American Journal of Physiology-Gastrointestinal and Liver Physiology is a physiology journal published by the American Physiological Society that covers gastrointestinal and liver physiology research and features research articles, reviews, editorials, articles in press, collections, podcasts, and calls for papers.

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Subject Gastroenterology & Hepatology
Impact Factor 3.3
Quartile Q2
Open Access Type Open
ISSN 0193-1857
eISSN 1522-1547
Invitation Only No
Cost Range Publishing discounts are available for APS members. The society will adopt the Subscribe to Open model for 10 primary research self-published journals starting in 2025.

Submission Instructions

American Journal of Physiology-Gastrointestinal and Liver Physiology accepts the following article types. Click on an article type to view submission instructions.

Research Articles

Cover Letter Cover Letter requirements are not specified.
Abstract Research Articles must include an abstract. Abstract must be 250 words.
Manuscript Research Articles must include an Introduction, Methods, Results, and Discussion. Research Articles must include a New & Noteworthy summary limited to 75 words, a Data Availability Statement, and, for American Journal of Physiology-Gastrointestinal and Liver Physiology, a graphical abstract.
References References must be numbered serially and arranged in the order of in-text citation, with citation numbers placed in parentheses in the text.
Figures & Tables Tables must be submitted in Word table format rather than as tabbed text or embedded images.
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Review Articles

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required and must be 250 words. Abstract must be 250 words.
Manuscript Manuscript is limited to 6,000 words. Manuscript must include up to 5 keywords.
References References must be numbered serially in the order of in-text citation, with citation numbers placed in parentheses.
Figures & Tables Review Articles may include up to 6 figures. Tables must be submitted in Word table format rather than as tabbed text or embedded images.
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Systematic Review

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required for Systematic Review articles. The abstract must be 250 words.
Manuscript The manuscript title must identify the article as a systematic review or meta-analysis, and the article must report the search strategy, inclusion and exclusion criteria, characteristics of extracted information, risk of bias across studies, and limitations of the search and analysis. The manuscript must include up to 5 keywords and author contributions for all authors, and any included meta-analysis must define the methods for data extraction and result combination along with confidence intervals and measures of consistency.
References References must be numbered serially and listed in the order of in-text citation, with citation numbers placed in parentheses in the text.
Figures & Tables New submissions must include figures and tables with the manuscript. Tables must be provided in Word table format rather than as tabbed text or embedded images.
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Short Reports

Cover Letter Cover Letter requirements are not specified.
Abstract Short Reports must include an abstract. Abstract must be 250 words.
Manuscript Short Reports are limited to 4,000 words excluding references and figure legends. Manuscript must include a Data Availability Statement and a link to repository-hosted supplemental material files.
References References must be numbered serially and arranged in the order of in-text citation, with citation numbers placed in parentheses in the text.
Figures & Tables Short Reports may include up to 4 figures or tables, excluding additional online materials. Supplemental material files must be uploaded to a repository and linked within the manuscript.
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Mini-Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required. Abstract must be 250 words.
Manuscript Manuscript should be approximately 3,000 words excluding references. Manuscript must include up to 5 keywords.
References References may total up to 50. References must be numbered serially in order of in-text citation, with citation numbers placed in parentheses in the text.
Figures & Tables Mini-Reviews may include 1–3 figures and/or tables. Previously published figures are permitted if permission is obtained from the copyright holder and the source is acknowledged.
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Review: Guidelines

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required. Abstract must be 250 words.
Manuscript Manuscript must be 10,000-25,000 words. Guidelines articles are consensus statements developed by leading experts. Manuscript must include up to 5 keywords, and keywords must avoid abbreviations.
References References must be numbered serially and arranged in the order of in-text citation, with reference numbers placed in parentheses in the text.
Figures & Tables Figures & Tables requirements are not specified.
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Letters To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Letters to the Editor are limited to 1,000 words, excluding references. Letters to the Editor must respond to work previously published in the journal. Letters to the Editor must not include new or unpublished data.
References Letters to the Editor may include no more than 10 references. References must be numbered serially and arranged in the order of in-text citation, with reference numbers placed in parentheses in the text.
Figures & Tables Letters to the Editor must not include figures or tables.
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Recent Publications

Ethanol reshapes FFC-driven steatohepatitis through time-dependent fibrosis and lipid-droplet remodeling

Jasmin Weninger, Amani Lee, George Marek, Naomi Lange, Amy S. Mauer, Gyanendra Puri, Vijay H. Shah, Harmeet Malhi

10.1152/ajpgi.00223.2026
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Integrated analyses of in vivo mouse models and liver organoids reveal MFG-E8-mediated protection against hepatocyte injury

Heng-Fu Henry Bu, Qianming Jiang, Hua Geng, Saravanan Subramanian, Nazeer Hussain Khan, Xiao Wang, Xiao-Di Tan

10.1152/ajpgi.00079.2026
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Three-Dimensional Architecture of the Liver Structural Organization, Methodological Advances, and Functional Implications

Roy Siegelmann, Jagoda Litowczenko-Cybulska, Gilad Gome, Tolga Durak, Ron Weiss

10.1152/ajpgi.00133.2026
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Colonic metabolomic and transcriptomic alterations in a mouse model of metabolic syndrome

Jaclyn A. Rivas, David P. Scieszka, Eduardo Peralta-Herrera, Crystal Madera Enriquez, Seth D. Merkley, Audrey L. Nava, Rama R. Gullapalli, Yan Guo, Eliseo F. Castillo

10.1152/ajpgi.00121.2026
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Contrasting Impacts of Two ABCB11 Variants Affecting the Same Residue in Progressive Familial Intrahepatic Cholestasis Type 2

Yosra Riahi, Marion Almes, Manon Banet, Elodie Mareux, Isabelle Garcin, Anne Davit-Spraul, Redouane Si-Bouazza, Sylvie Fabrega, Benjamin Boucherle, Jean-Luc Decout, Thomas Falguières, Isabelle Callebaut, Emmanuel Jacquemin, Emmanuel Gonzales, Martine Lapalus

10.1152/ajpgi.00055.2026
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Frequently asked questions

How long does it take to publish?

Proofs are usually provided within several weeks. Articles are published when ready under a continuous publication model.

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Is a cover letter required?

A cover letter is referenced for NPRC submissions; authors should state that they are submitting an NPRC paper, describe the changes made, and include the name and manuscript ID of the original journal.

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What are the publication costs?

Publishing discounts are available for APS members. The society will adopt the Subscribe to Open model for 10 primary research self-published journals starting in 2025.

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Research Topics

Gastrointestinal motility and disorders Neuropeptides and Animal Physiology Ion Transport and Channel Regulation Drug Transport and Resistance Mechanisms Helicobacter pylori-related gastroenterology studies Gastroesophageal reflux and treatments Liver Disease Diagnosis and Treatment Diet and metabolism studies Pancreatic function and diabetes Ion channel regulation and function Clinical Nutrition and Gastroenterology Pancreatitis Pathology and Treatment Liver Disease and Transplantation Nitric Oxide and Endothelin Effects Digestive system and related health Pediatric Hepatobiliary Diseases and Treatments Liver physiology and pathology Receptor Mechanisms and Signaling Ion Channels and Receptors Gut microbiota and health Immune Response and Inflammation Neuroscience of respiration and sleep Diabetes Treatment and Management Organ Transplantation Techniques and Outcomes Dysphagia Assessment and Management

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