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CPT Pharmacometrics & Systems Pharmacology

CPT: Pharmacometrics & Systems Pharmacology (PSP) is a cross-disciplinary journal devoted to publishing advances in quantitative methods, including modeling and simulation, as applied in pharmacology, physiology, and therapeutics in humans. It is an official open access journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT).

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Impact Factor 3
Quartile Q2
Open Access Type Open
ISSN 2163-8306
eISSN 2163-8306
Invitation Only No
Cost Range APC: $4,350 USD / £3,300 GBP / €3,650 EUR; waived for Commentary, Media Review, and Perspective.

Submission Instructions

CPT Pharmacometrics & Systems Pharmacology accepts the following article types. Click on an article type to view submission instructions.

Article

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required and must be 250 words. Abstract must be 250 words.
Manuscript Manuscript must not exceed 4,000 words, excluding the title page, abstract or introduction, references, acknowledgements, tables, and figures. Manuscript must be organized in this order: Title Page, Abstract, Introduction, Methods, Results, Discussion, Study Highlights, Graphical Abstracts, Acknowledgements, Author Contributions, References, Figure Legends, and Supplementary Information Titles. Manuscript must include keywords on the title page, an Author Contributions section, AI-use disclosure in the acknowledgements or methods if applicable, and a Study Highlights section after the Discussion that answers four specified questions in under 150 words excluding the questions.
References References must be listed in the order cited, include only published works or manuscripts in press, give all authors up to 6 and otherwise the first 3 followed by et al., and include article titles.
Figures & Tables Figures and tables must be uploaded separately from the manuscript text, with figure legends placed after the References section in the manuscript. Figures and tables must be numbered consecutively in the order first cited, each figure must be provided as an individual file, composite figures should be preassembled, each table must have a brief title, and multipart tables are not allowed.
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Review

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required for Review manuscripts. Abstract must be 250 words.
Manuscript Review manuscripts must not exceed 8,000 words. Keywords must be included on the title page, the manuscript must include an Author Contributions section, and any AI use must be credited in the acknowledgements or methods section.
References References must be listed in citation order, include only published works or manuscripts in press, and list all authors up to 6 or the first 3 followed by 'et al.' when applicable.
Figures & Tables Figures and tables must be uploaded separately from the manuscript text. Figure legends must appear after the References section, each figure must be uploaded as an individual file, and multipart tables are not allowed.
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Systematic Review

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required. Abstract must be 250 words.
Manuscript Manuscript must not exceed 8,000 words, excluding the title page, abstract or introduction, references, acknowledgements, tables, and figures. The title page must include keywords, the manuscript must include an Author Contributions section, and any AI use must be credited in the acknowledgements or methods section.
References References must be listed in the order cited, include only published works and manuscripts in press, include article titles, and list all authors up to 6 or the first 3 followed by et al. when applicable.
Figures & Tables Figures and tables must be uploaded separately from the manuscript text, and figure legends must appear after the References section in the manuscript text. Each figure must be provided as an individual file, composite figures should be preassembled, and each table must have a brief title.
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Meta-Analysis

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required. Abstract must be 250 words.
Manuscript Manuscript must not exceed 8,000 words. Keywords must be included on the title page, and any use of AI must be credited in the acknowledgements or methods section.
References References must be listed in the order cited, include all authors up to 6 or the first 3 followed by 'et al.' when applicable, and include article titles.
Figures & Tables Figures and tables must be uploaded separately from the manuscript text. Figures must be numbered consecutively and submitted as individual files, and tables must be numbered consecutively.
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Letter To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Manuscript requirements are not specified.
References The original source must be referenced, response letters must reference the Letter to the Editor in the first few paragraphs, and references must be listed in citation order with all authors up to 6 and the first 3 followed by 'et al.' when applicable.
Figures & Tables Figures and tables must be uploaded separately from the manuscript text.
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Mini-Review

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required for Mini-Review manuscripts. The abstract must be 250 words.
Manuscript Mini-Review manuscripts must be 2,000–3,000 words, excluding the title page, abstract or introduction, references, acknowledgements, tables, and figures. The title page must include keywords, the manuscript must include an Author Contributions section, and any AI use must be credited in the acknowledgements or methods section.
References References must be listed in citation order, include article titles, and list all authors up to 6 or the first 3 followed by 'et al.' when applicable.
Figures & Tables Figures and tables must be uploaded separately from the manuscript text, with each figure provided as an individual file. Figure legends must appear after the References section, and multipart tables are not allowed.
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Psp Case Reports

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required. Abstract must be 250 words.
Manuscript Manuscript must not exceed 2,000 words. Manuscript should be organized as Introduction, Key question, Analysis Plan and Key Assumptions, Results, Impact Assessment, and Conclusion. Keywords must be included on the title page, and AI use must be credited in the acknowledgements or methods section.
References References must be listed in the order cited, include article titles, and list up to six authors or the first three followed by et al. when applicable.
Figures & Tables Figures and tables must be uploaded separately from the manuscript text. Figure legends must appear after the References section, each figure must be uploaded as an individual file, and multipart tables are not allowed.
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Recent Publications

OpenPMX Software for Nonlinear Mixed‐Effect Models in Pharmacometrics: Precision Compared With NONMEM First‐Order Conditional Estimation

Douglas J. Eleveld, Jeroen V. Koomen, Jasper Stevens, Pieter J. Colin, Michel M. R. F. Struys

10.1002/psp4.70250
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Development of the Weight‐Tiered Q3W Regimen of Amivantamab in Combination With Carboplatin‐Pemetrexed in EGFR ‐Mutated Non‐Small Cell Lung Cancer

Dongfen Yuan, Corey J. Bishop, Jaydeep Mehta, Wangda Zhou, Lu Zhang, Jie Zhou, Raja Venkatasubramanian, Alex Yu, Trishala Agrawal, Sujay Shah, Mahadi Baig, Joshua M. Bauml, Pritam Kambuj, Lahila‐Carina Ojeda, Pamela L. Clemens, Nahor Haddish‐Berhane, Yaming Su, Mahesh Samtani

10.1002/psp4.70263
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Physiologically Based Pharmacokinetic Modeling of Elexacaftor/Tezacaftor/Ivacaftor in Infants With Cystic Fibrosis

Ngoc Hoa Truong, Sihem Benaboud, Naïm Bouazza, Eric Deneuville, Anne Mornand, Philippe Reix, Mélanie Ribault, Pierre‐Régis Burgel, Léo Froelicher‐Bournaud, Steeve Rouillon, Mohammed Rohi Sanoufi, Gabrielle Lui, Saïk Urien, Jean‐Marc Tréluyer, Isabelle Sermet‐Gaudelus, Frantz Foissac

10.1002/psp4.70225
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External Evaluation of Population Pharmacokinetic Models of Cabotegravir, During Its Oral and Intramuscular Administration in HIV ‐Infected Patients

Quentin Renou, Nadège Néant, Alexandre Destere, Jennifer Lagoutte‐Renosi, Matthieu Grégoire, François Parant, Sébastien Lalanne, Florian Lemaitre, Peggy Gandia, Nicolas Venisse, Stéphane Bouchet, Minh P. Lê, Patrice Muret, Gilles Peytavin, Caroline Solas, Sihem Benaboud

10.1002/psp4.70180
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Breaking Barriers Between Species: Integrated Multi‐Species PK Models Improve Human PK Predictions

Miriam S. R. Happ, Jens M. Borghardt, Charlotte Kloft, Hermann Rapp, Achim Sauer, Anneke Himstedt, Bettina Gerner

10.1002/psp4.70262
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Frequently asked questions

How long does it take to publish?

Median 39 days from submission to first decision, 124 days from submission to acceptance, and 25 days from acceptance to publication.

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Is a cover letter required?

A cover letter is required when there has been no Institutional Review Board review of a study, and it should indicate that no IRB review occurred.

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What are the publication costs?

Article publication charge: $4,350 USD / £3,300 GBP / €3,650 EUR for accepted and published articles. No submission fees or page charges. The APC is waived for Commentary, Media Review, and Perspective.

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Research Topics

Statistical Methods in Clinical Trials Pharmacogenetics and Drug Metabolism Computational Drug Discovery Methods Drug Transport and Resistance Mechanisms Antibiotics Pharmacokinetics and Efficacy Monoclonal and Polyclonal Antibodies Research Pharmaceutical studies and practices Biosimilars and Bioanalytical Methods Biotin and Related Studies Health Systems, Economic Evaluations, Quality of Life Diverse Scientific and Economic Studies Educational Robotics and Engineering Human auditory perception and evaluation Cancer Genomics and Diagnostics Pharmacological Effects and Toxicity Studies Statistical Methods and Bayesian Inference Diabetes Treatment and Management Lung Cancer Treatments and Mutations Receptor Mechanisms and Signaling Mathematical Biology Tumor Growth Analytical Chemistry and Chromatography Cancer Immunotherapy and Biomarkers Gene Regulatory Network Analysis HIV/AIDS drug development and treatment Advanced Causal Inference Techniques