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Frontiers in Aging

Frontiers in Aging explores the biological processes of human aging and publishes research that advances understanding of human aging and its fundamental link with age-related diseases.

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Impact Factor 4.3
Quartile Q1
Open Access Type Open
eISSN 2673-6217
Invitation Only No
Cost Range A-Type Articles: CHF 3,150; B-Type Articles: CHF 2,500.

Submission Instructions

Frontiers in Aging accepts the following article types. Click on an article type to view submission instructions.

Original Research

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must be structured in a single paragraph, for example following IMRAD format.
Manuscript Manuscript must not exceed 12,000 words. Manuscript should follow the format Abstract, Introduction, Materials and Methods, Results, and Discussion, with the main text organized as Introduction, Materials and Methods, Results, and Discussion. Manuscript must include 5 to 8 keywords, indicate the number of words and the number of figures and tables on the first page, and acknowledge any use of generative AI in the acknowledgments and in the methods section if applicable.
References Citations and references must follow the journal's reference style. References should list the first six authors followed by et al. when applicable, abbreviate given names to initials, include the DOI when available, and include only works that are published or accepted with 'in press' used for accepted unpublished items.
Figures & Tables Figures must be submitted individually with captions placed at the end of the manuscript, while tables must be directly inserted at the end of the manuscript in editable format. Each figure and table must be cited in numerical order in the text, multi-panel figures must use labeled panels such as (A), (B), and figure alternative text is required.
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Systematic Review

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must be structured in a single paragraph.
Manuscript Manuscript must not exceed 12,000 words. Manuscript should be organized as Abstract, Introduction, Methods, Results, and Discussion, with the research question clearly defined in terms of PICOS and the Methods, Results, and Discussion sections containing the specified systematic review content. Manuscript must include 5 to 8 keywords, funding information or a statement that there was no specific funding, a 200-word scope statement, a 200-word contribution-to-the-field statement, and acknowledgement of any generative AI use in the acknowledgements and methods sections if applicable.
References Citations and references must follow the journal's reference style. References should list the first six authors followed by et al. and include the DOI when available, and unpublished material including unpublished or original data, submitted manuscripts, and personal communications must not be included.
Figures & Tables Figures must be submitted individually with captions placed at the end of the manuscript, while tables must be directly inserted at the end of the manuscript in editable format. Figures should include alternative text and multi-panel figures should use labels such as (A), (B), and tables and figures must be cited in numerical order in the text.
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Review

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must be structured in a single paragraph.
Manuscript Manuscript must not exceed 12,000 words. Manuscript must be organized as Abstract, Introduction, subject-relevant subsections, and Discussion. Manuscript must include 5 to 8 keywords, indicate the word count and number of figures and tables on the first page, and disclose any use of generative AI in the acknowledgements and in the methods section if applicable.
References References must follow the journal's reference style, list the first six authors followed by et al. with authors' given names abbreviated to initials, include the DOI when available, and exclude unpublished material and personal communications.
Figures & Tables Figures must be submitted individually with captions placed at the end of the manuscript, while tables must be directly inserted at the end of the manuscript in editable format. All figures or images must include alternative text.
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Clinical Trial

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must be structured and presented as a single paragraph. Abstract must include the clinical trial registry number.
Manuscript Manuscript must not exceed 12,000 words. Manuscript should be organized as Abstract, Introduction, Materials and Methods, Results, and Discussion. Manuscript must include 5 to 8 keywords, and any use of generative AI to produce or edit written or visual content must be disclosed in the acknowledgments and in the methods section if applicable with the tool name, version, model, and source.
References Citations and references must follow the journal's reference style. References should list the first six authors followed by et al., abbreviate given names to initials, and include the DOI when available.
Figures & Tables Figures must be submitted individually with captions placed at the end of the manuscript, while tables must be directly inserted into the manuscript and placed at the end. Randomized clinical trials must include a CONSORT flow diagram in the figures or supplementary material.
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Mini Review

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must be structured in a single paragraph.
Manuscript Manuscript must not exceed 3,000 words. Manuscript must be organized as Abstract, Introduction, subject-relevant subsections, and Discussion. Manuscript must discuss different schools of thought or controversies, current research gaps, potential future developments in the field, include 5 to 8 keywords, and acknowledge any use of generative AI in the acknowledgments and methods where applicable.
References References must follow the journal reference style, list the first six authors followed by et al. with author given names abbreviated to initials and DOI when available, and must not include unpublished material, submitted manuscripts, or personal communications.
Figures & Tables Mini Review articles may include no more than 2 figures and/or tables in total. Figures must be submitted individually with captions at the end of the manuscript, and tables must be inserted directly into the manuscript at the end. All figures or images should include alternative text.
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Case Report

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required. The abstract should be structured as a single paragraph.
Manuscript The manuscript must not exceed 3,000 words. The manuscript should be organized as Abstract, Introduction, Case description, a figure or table presenting a timeline, Diagnostic assessment with details on the therapeutic intervention, follow-up and outcomes, Discussion, and Patient perspective. The manuscript must use the title format "Case Report: 'area of focus'" and include at least 5 and no more than 8 keywords, a 200-word scope statement, a 200-word contribution to the field statement, and an acknowledgements disclosure of any generative AI use including the name, version, model, and source.
References References must follow the journal's reference style and list the first six authors followed by et al., with authors' given names abbreviated to initials and DOI included when available.
Figures & Tables No more than 4 display items, including figures, tables, or videos, are allowed. Figures must be submitted individually with captions at the end of the manuscript, while tables must be directly inserted into the manuscript. The manuscript must include a figure or table that showcases a timeline with relevant data from the episode of care.
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Data Report

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract should be structured in a single paragraph, for example following IMRAD format.
Manuscript Manuscript must not exceed 3,000 words. Manuscript should be organized as Introduction, Methods used to collect the data, some analysis of the data, and relevant subsections, and it must not include Results or Discussion sections. Manuscript must include the dataset name, the database or repository where it was submitted, a confidential peer-review link to the dataset that is updated to the public link before publication, methods describing the data collection period and any filters applied, guidance on interpreting and reusing the dataset, at least 5 and no more than 8 keywords, and an acknowledgment of any generative AI use with the tool name, version, model, and source.
References References must follow the journal reference style, list the first six authors followed by et al. when applicable, abbreviate given names to initials, and include the DOI when available.
Figures & Tables Manuscript may contain no more than 2 figures and/or tables. Figures must be submitted individually with captions at the end of the manuscript, while tables must be directly inserted into the manuscript and placed at the end in editable format. Figures must be cited in numerical order and include alternative text, and each table must be cited in numerical order with its caption placed immediately before the table.
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Brief Research Report

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must be structured as part of the format Abstract, Introduction, Method, Results, Discussion and be no longer than a single paragraph.
Manuscript Manuscript must not exceed 4,000 words. Manuscript should follow the format Abstract, Introduction, Method, Results, Discussion. Manuscript must include 5 to 8 keywords, indicate the number of words and the number of figures and tables on the first page, and acknowledge any use of generative AI in the acknowledgements and in the methods section if applicable.
References Citations and references must adhere to the journal's reference style. References should list the first six authors followed by et al., abbreviate given names to initials, include the DOI when available, and include only works that are published or accepted.
Figures & Tables Brief Research Report articles may contain no more than 4 figures and tables in total. Figures must be submitted individually, figure captions must be placed at the end of the manuscript, and tables must be directly inserted into the manuscript at the end in editable format. Each figure and table must be mentioned in the text in numerical order, and figures or images should include alternative text.
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Technology And Code

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must be structured in a single paragraph.
Manuscript Manuscript must not exceed 12,000 words. Manuscript must be organized as Abstract, Introduction, Method, Results, and Discussion, with the Method section including any code description, the Results section including examples of use and limitations, and the Discussion section including scalability and limitations. Manuscript must include a project link such as SourceForge or GitHub, the operating system, the programming language, any restrictions for non-academic use, at least five and no more than eight keywords, and an acknowledgment of generative AI use with the tool name, version, model, and source if such tools were used.
References Citations and references must adhere to the journal's reference style. References should list the first six authors followed by et al., abbreviate given names to initials, include the DOI when available, and include only works that are published or accepted.
Figures & Tables Figures must be submitted individually with captions placed at the end of the manuscript, while tables must be directly inserted into the manuscript and placed at the end. Each figure and table must be cited in numerical order in the text, and figure panels should be labeled with capital letters.
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Fair² Data

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must be structured in a single paragraph, for example following the IMRAD format.
Manuscript Manuscript must not exceed 12,000 words. Manuscript must be organized using headings and subheadings. Manuscript must include 5 to 8 keywords, indicate the number of words and figures and tables on the first page, and acknowledge any generative AI use in the acknowledgments and methods when applicable with the tool name, version, model, and source.
References Citations and references must follow the journal's reference style. References must list the first six authors followed by et al., abbreviate given names to initials, include the DOI when available, and include only works that are published or accepted.
Figures & Tables FAIR² Data articles may include no more than 15 figures or tables. Figures must be submitted individually and captions placed at the end of the manuscript, while tables must be directly inserted into the manuscript at the end. Each figure and table must be cited in numerical order in the text, and figure panels must be labeled with letters such as (A), (B), and (C).
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Recent Publications

The SIRT1–p53 axis drives a ferro-aging-like program and aggravates trophoblast dysfunction in preeclampsia

Rong Hu, Zhi Chen, Wei Bian, Jing Zhang, Xiaoqin Xu, Hui Xiong, Shaojian Xiang, Yubin Ding, Hongbo Qi, Huan Yang

10.3389/fragi.2026.1838730
View Publication

The metabolic-epigenetic landscape of aging: interplay between histone acetylation, lactylation, and glycation

Olena Bolgova, Inna Shypilova, Volodymyr Mavrych

10.3389/fragi.2026.1854915
View Publication

Homeodynamic Rejuvenation: an adaptive framework for resetting skin aging

Anthony Brown, Carla Simonetto, Carlos López-Otín

10.3389/fragi.2026.1840035
View Publication

Studying exercise-induced affect in older adults: how the circumplex model could enhance theoretical and practical advances in the field

Attila Szabo, Celal Bulgay, Erzsébet Stephens-Sarlós, Róbert Járai, Angéla Somogyi, Szilvia Boros, Robert Podstawski, Ferenc Ihász, Roberto Ruíz-Barquín, Ricardo de la Vega

10.3389/fragi.2026.1780273
View Publication

Physiological amplitude: a systems-level framework for adaptive capacity in aging and metabolism

Grazyna Sepczynska

10.3389/fragi.2026.1837722
View Publication

Frequently asked questions

How long does it take to publish?

A decision on a manuscript is given in 77 days.

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Is a cover letter required?

A traditional cover letter is not permitted. Authors must instead provide a 200-word contribution-to-the-field statement during submission.

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What are the publication costs?

Article processing charges apply to accepted articles. A-Type Articles cost CHF 3,150 and B-Type Articles cost CHF 2,500. Full or partial APC support may be available through institutional partnerships, and discounts may be available for authors in low or lower-middle income countries.

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Research Topics

Genetics, Aging, and Longevity in Model Organisms Nutrition and Health in Aging Frailty in Older Adults Telomeres, Telomerase, and Senescence Balance, Gait, and Falls Prevention Dementia and Cognitive Impairment Research Epigenetics and DNA Methylation Mitochondrial Function and Pathology Immune Cell Function and Interaction Adipose Tissue and Metabolism Neuroinflammation and Neurodegeneration Mechanisms Physical Activity and Health Health disparities and outcomes Circadian rhythm and melatonin Diet and metabolism studies Alzheimer's disease research and treatments Bone health and osteoporosis research Skin Protection and Aging Dietary Effects on Health Gut microbiota and health Nutritional Studies and Diet Cardiovascular and exercise physiology T-cell and B-cell Immunology Immune responses and vaccinations Stroke Rehabilitation and Recovery